DOI: 10.1161/01.res.0000117769.88862.f8. The Giant Protein Titin

10.1161/01.res.0000117769.88862.f8

Crossref journal-article

Ovid Technologies (Wolters Kluwer Health)

Circulation Research (276)

Abstract

The sarcomere contains, in addition to thin and thick filaments, a filament composed of the giant protein titin (also known as connectin). Titin molecules anchor in the Z-disc and extend to the M-line region of the sarcomere. The majority of titin’s I-band region functions as a molecular spring. This spring maintains the precise structural arrangement of thick and thin filaments, and gives rise to passive muscle stiffness; an important determinant of diastolic filling. Earlier work on titin has been reviewed before. In this study, our main focus is on recent findings vis-à-vis titin’s molecular spring segments in cardiac titins, including the discovery of fetal cardiac isoforms with novel spring elements. We also discuss new insights regarding the role of titin as a biomechanical sensor and signaling molecule. We will end with focusing on the rapidly growing knowledge regarding titinopathies.

Bibliography

Granzier, H. L., & Labeit, S. (2004). The Giant Protein Titin. Circulation Research, 94(3), 284â295.

Authors 2

Henk L. Granzier (first)
Siegfried Labeit (additional)

References 97 Referenced 496

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Dates

Type	When
Created	21 years, 6 months ago (Feb. 19, 2004, 4:38 p.m.)
Deposited	1 year, 3 months ago (May 12, 2024, 2:14 p.m.)
Indexed	4 weeks, 1 day ago (Aug. 7, 2025, 4:27 p.m.)
Issued	21 years, 6 months ago (Feb. 20, 2004)
Published	21 years, 6 months ago (Feb. 20, 2004)
Published Print	21 years, 6 months ago (Feb. 20, 2004)

Funders 0

None

BibTeX

@article{Granzier_2004, title={The Giant Protein Titin: A Major Player in Myocardial Mechanics, Signaling, and Disease}, volume={94}, ISSN={1524-4571}, url={http://dx.doi.org/10.1161/01.res.0000117769.88862.f8}, DOI={10.1161/01.res.0000117769.88862.f8}, number={3}, journal={Circulation Research}, publisher={Ovid Technologies (Wolters Kluwer Health)}, author={Granzier, Henk L. and Labeit, Siegfried}, year={2004}, month=feb, pages={284–295} }

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