DOI: 10.1161/01.cir.95.7.1791. Contribution of Inadequate Arterial Remodeling to the Development of Focal Coronary Artery Stenoses

Contribution of Inadequate Arterial Remodeling to the Development of Focal Coronary Artery Stenoses

10.1161/01.cir.95.7.1791

Crossref journal-article

Ovid Technologies (Wolters Kluwer Health)

Circulation (276)

Abstract

Background Adaptive remodeling occurs to compensate for the accumulation of atherosclerotic plaque. Lumen reduction depends on the relative rates of plaque deposition and adaptive remodeling responses. Intravascular ultrasound permits detailed, high-quality, cross-sectional imaging of the coronary arteries in vivo. Methods and Results Preintervention intravascular ultrasound was used to study 603 focal, new, nonostial significant coronary artery stenoses in patients with chronic stable angina. Measurements of the target lesion of the external elastic membrane (EEM), lumen, and plaque plus media (P&M; P&M=EEM−Lumen) cross-sectional areas (CSAs) were compared with a proximal reference segment (most normal-looking cross section within 10 mm proximal to the lesion but distal to any side branch). Inadequate remodeling was defined as lesion/reference EEM CSA that exceeded the upper limits of normal arterial tapering (lesion/reference EEM CSA ratio ≤0.78 or a 21% reduction in EEM CSA per 10-mm length). Overall, the lesion/reference EEM CSA ratio was 1.00±0.22; 15% of lesions had inadequate remodeling, and 37% of the 603 lesions had less plaque than expected. This represented a lesion-specific response. The only predictor of inadequate remodeling was the arc of superficial lesion calcium. Conclusions Inadequate remodeling is present in at least 15% of chronic, focal, new coronary arterial stenoses in patients with stable angina. The magnitude of arterial remodeling appears to be a lesion-specific response.

Bibliography

Mintz, G. S., Kent, K. M., Pichard, A. D., Satler, L. F., Popma, J. J., & Leon, M. B. (1997). Contribution of Inadequate Arterial Remodeling to the Development of Focal Coronary Artery Stenoses. Circulation, 95(7), 1791â1798.

Authors 6

Gary S. Mintz (first)
Kenneth M. Kent (additional)
Augusto D. Pichard (additional)
Lowell F. Satler (additional)
Jeffrey J. Popma (additional)
Martin B. Leon (additional)

References 53 Referenced 230

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Dates

Type	When
Created	13 years, 2 months ago (June 11, 2012, 8:41 p.m.)
Deposited	1 year, 3 months ago (May 12, 2024, 12:26 p.m.)
Indexed	1 day, 9 hours ago (Sept. 3, 2025, 7:08 a.m.)
Issued	28 years, 5 months ago (April 1, 1997)
Published	28 years, 5 months ago (April 1, 1997)
Published Print	28 years, 5 months ago (April 1, 1997)

Funders 0

None

BibTeX

@article{Mintz_1997, title={Contribution of Inadequate Arterial Remodeling to the Development of Focal Coronary Artery Stenoses: An Intravascular Ultrasound Study}, volume={95}, ISSN={1524-4539}, url={http://dx.doi.org/10.1161/01.cir.95.7.1791}, DOI={10.1161/01.cir.95.7.1791}, number={7}, journal={Circulation}, publisher={Ovid Technologies (Wolters Kluwer Health)}, author={Mintz, Gary S. and Kent, Kenneth M. and Pichard, Augusto D. and Satler, Lowell F. and Popma, Jeffrey J. and Leon, Martin B.}, year={1997}, month=apr, pages={1791–1798} }

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    "10.1161/01.CIR.95.7.1791"
  ],
  "URL": "http://dx.doi.org/10.1161/01.CIR.95.7.1791",
  "relation": {},
  "ISSN": [
    "0009-7322",
    "1524-4539"
  ],
  "subject": [],
  "container-title-short": "Circulation",
  "published": {
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      [
        1997,
        4
      ]
    ]
  },
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