DOI: 10.1161/01.cir.92.5.1223. Acute Hypertension Induces Heat-Shock Protein 70 Gene Expression in Rat Aorta

Acute Hypertension Induces Heat-Shock Protein 70 Gene Expression in Rat Aorta

10.1161/01.cir.92.5.1223

Crossref journal-article

Ovid Technologies (Wolters Kluwer Health)

Circulation (276)

Abstract

BackgroundMany factors cause acute systemic hypertension, which in turn can result in damage to the vessel wall and lead to vascular disease. In previous studies, we demonstrated that restraint, or immobilization stress, results in the induction of heat-shock protein 70 (hsp70) gene expression in the aorta of adult rat and showed that this response was markedly attenuated with age.Methods and ResultsHere we provide evidence that restraint-induced hsp70 expression occurs secondary to a rise in systemic blood pressure. Old rats were unable to mount a significant stress-induced hypertensive response, providing an explanation for the reduced hsp70 response in the old rats. A variety of vasoactive agents that induce acute hypertension through distinct signal transduction pathways, including phenylephrine, dopamine, vasopressin, angiotensin II, and endothelin-1, were found to result in hsp70 mRNA induction in the aorta. The magnitude of hsp70 expression achieved with these hypertensive agents was directly correlated with their relative effects on blood pressure. Rats were treated with the vasodilator sodium nitroprusside, which prevented an acute rise in blood pressure from the hypertensive agents tested and abolished induction of hsp70 expression.ConclusionsThese findings support the conclusion that hsp70 induction occurs as a physiological response to acute hypertension and suggest the possibility that hsp70 plays a role in the protecting the vasculature from damage during hemodynamic stress.

Bibliography

Xu, Q., Li, D., Holbrook, N. J., & Udelsman, R. (1995). Acute Hypertension Induces Heat-Shock Protein 70 Gene Expression in Rat Aorta. Circulation, 92(5), 1223â1229.

Authors 4

Qingbo Xu (first)
Ding-gang Li (additional)
Nikki J. Holbrook (additional)
Robert Udelsman (additional)

References 33 Referenced 70

10.1146/annurev.ge.22.120188.003215
Holbrook NJ Udelsman R. Heat shock protein gene expression in response to physiologic stress and aging. In: Morimoto RI Tissieres A Georgopoulous C eds. The Biology of Heat Shock Proteins and Molecular Chaperones. Cold Spring Harbor NY: Cold Spring Harbor Laboratory Press; 1994;577-593.
Morimoto RI Tissieres A Georgopoulous C. The stress response function of the proteins and perspectives. In: Morimoto RI Tissieres A Georgopoulous C eds. Stress Proteins in Biology and Medicine. Cold Spring Harbor NY: Cold Spring Harbor Laboratory Press; 1990:1-13.
Gething MJ, Sambrook J. Protein folding in the cells. Nature. 1992;355:34-44. / Nature (1992)
10.1016/0092-8674(94)90416-2
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Udelsman R, Blake MJ, Holbrook NJ. Molecular response to surgical stress: specific and simultaneous heat shock protein induction in the adrenal cortex, aorta, and vena cava. Surgery. 1991;110:1125-1131. / Surgery (1991)
10.1210/endo.132.3.8095012
Blake MJ, Buckley DJ, Buckley AR, Lavoi KP, Bartlett T. Neural and endocrine mechanisms of cocaine-induced 7-kDa heat shock protein expression in aorta and adrenal gland. J Pharmacol Exp Ther. 1994;268:522-529. (10.1016/S0022-3565(25)38502-2) / J Pharmacol Exp Ther (1994)
Ross R Kariya B. Smooth muscle cells in culture. In: Bohr DF Somlyo AP Sparks HV eds. Handbook of Physiology: Circulation Vascular Smooth Muscle. Bethesda Md: American Physiological Society; 1980:69-91. (10.1002/cphy.cp020203)
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Pickering TG. The study of blood pressure in every day life. In: Elbert T Vailt D eds. Behavioural Medicine in Cardiovascular Disorders. New York NY: John Wiley & Sons; 1988;71-85.
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10.1056/NEJM199405123301902
10.1016/0140-6736(90)90878-9

Dates

Type	When
Created	13 years, 2 months ago (June 11, 2012, 8:34 p.m.)
Deposited	5 months ago (March 30, 2025, 4:25 p.m.)
Indexed	1 month, 1 week ago (July 25, 2025, 6:24 a.m.)
Issued	30 years ago (Sept. 1, 1995)
Published	30 years ago (Sept. 1, 1995)
Published Print	30 years ago (Sept. 1, 1995)

Funders 0

None

BibTeX

@article{Xu_1995, title={Acute Hypertension Induces Heat-Shock Protein 70 Gene Expression in Rat Aorta}, volume={92}, ISSN={1524-4539}, url={http://dx.doi.org/10.1161/01.cir.92.5.1223}, DOI={10.1161/01.cir.92.5.1223}, number={5}, journal={Circulation}, publisher={Ovid Technologies (Wolters Kluwer Health)}, author={Xu, Qingbo and Li, Ding-gang and Holbrook, Nikki J. and Udelsman, Robert}, year={1995}, month=sep, pages={1223–1229} }

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