DOI: 10.1161/01.cir.1.4.822. Studies of Tissue Response to Injections of Enzymes

Studies of Tissue Response to Injections of Enzymes

10.1161/01.cir.1.4.822

Crossref journal-article

Ovid Technologies (Wolters Kluwer Health)

Circulation (276)

Abstract

Hexosamine-containing polysaccharides have been demonstrated in plasma and various tissues including skin, cartilage and heart. Plasma hexosamine elevations have been observed in rheumatic fever, sterile infarcts and tuberculosis. It is possible that plasma polysaccharide changes reflect alterations of tissue polysaccharides. Thirty-six hours following a single subcutaneous injection of trypsin, a significant elevation of tissue hexosamine occurred at the injection sites. This appeared long before any visible or palpable change. The tissue hexosamine paralleled the developmental course of the "nodules." These findings appear specifically related to trypsin, since they failed to occur with other enzymes or test substances.

Bibliography

SCHLAMOWITZ, S. T., DEGRAFF, A. C., & SCHUBERT, M. (1950). Studies of Tissue Response to Injections of Enzymes. Circulation, 1(4), 822â832.

Authors 3

SAMUEL THEODORE SCHLAMOWITZ (first)
ARTHUR C. DEGRAFF (additional)
MAXWELL SCHUBERT (additional)

References 0 Referenced 3

None

Dates

Type	When
Created	13 years, 2 months ago (June 11, 2012, 7:15 p.m.)
Deposited	1 year, 3 months ago (May 12, 2024, 9:04 a.m.)
Indexed	1 year, 3 months ago (May 12, 2024, 8:07 p.m.)
Issued	75 years, 5 months ago (April 1, 1950)
Published	75 years, 5 months ago (April 1, 1950)
Published Print	75 years, 5 months ago (April 1, 1950)

Funders 0

None

BibTeX

@article{SCHLAMOWITZ_1950, title={Studies of Tissue Response to Injections of Enzymes: II. Changes in Rabbit Plasma and Tissue Hexosamine Induced by a Single Subcutaneous Injection of Trypsin}, volume={1}, ISSN={1524-4539}, url={http://dx.doi.org/10.1161/01.cir.1.4.822}, DOI={10.1161/01.cir.1.4.822}, number={4}, journal={Circulation}, publisher={Ovid Technologies (Wolters Kluwer Health)}, author={SCHLAMOWITZ, SAMUEL THEODORE and DEGRAFF, ARTHUR C. and SCHUBERT, MAXWELL}, year={1950}, month=apr, pages={822–832} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        5,
        13
      ]
    ],
    "date-time": "2024-05-13T00:07:53Z",
    "timestamp": 1715558873453
  },
  "reference-count": 0,
  "publisher": "Ovid Technologies (Wolters Kluwer Health)",
  "issue": "4",
  "content-domain": {
    "domain": [
      "www.ahajournals.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1950,
        4
      ]
    ]
  },
  "abstract": "<jats:p>Hexosamine-containing polysaccharides have been demonstrated in plasma and various tissues including skin, cartilage and heart. Plasma hexosamine elevations have been observed in rheumatic fever, sterile infarcts and tuberculosis. It is possible that plasma polysaccharide changes reflect alterations of tissue polysaccharides. Thirty-six hours following a single subcutaneous injection of trypsin, a significant elevation of tissue hexosamine occurred at the injection sites. This appeared long before any visible or palpable change. The tissue hexosamine paralleled the developmental course of the \"nodules.\" These findings appear specifically related to trypsin, since they failed to occur with other enzymes or test substances.</jats:p>",
  "DOI": "10.1161/01.cir.1.4.822",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2012,
        6,
        11
      ]
    ],
    "date-time": "2012-06-11T23:15:32Z",
    "timestamp": 1339456532000
  },
  "page": "822-832",
  "update-policy": "http://dx.doi.org/10.1161/crossmarkpolicy",
  "source": "Crossref",
  "is-referenced-by-count": 3,
  "title": "Studies of Tissue Response to Injections of Enzymes",
  "prefix": "10.1161",
  "volume": "1",
  "author": [
    {
      "given": "SAMUEL THEODORE",
      "family": "SCHLAMOWITZ",
      "sequence": "first",
      "affiliation": [
        {
          "name": "From the Department of Therapeutics, New York University College of Medicine, New York, N. Y."
        }
      ]
    },
    {
      "given": "ARTHUR C.",
      "family": "DEGRAFF",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "From the Department of Therapeutics, New York University College of Medicine, New York, N. Y."
        }
      ]
    },
    {
      "given": "MAXWELL",
      "family": "SCHUBERT",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "From the Department of Therapeutics, New York University College of Medicine, New York, N. Y."
        }
      ]
    }
  ],
  "member": "276",
  "container-title": "Circulation",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.1.4.822",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        5,
        12
      ]
    ],
    "date-time": "2024-05-12T13:04:31Z",
    "timestamp": 1715519071000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.ahajournals.org/doi/10.1161/01.CIR.1.4.822"
    }
  },
  "subtitle": [
    "II. Changes in Rabbit Plasma and Tissue Hexosamine Induced by a Single Subcutaneous Injection of Trypsin"
  ],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1950,
        4
      ]
    ]
  },
  "references-count": 0,
  "journal-issue": {
    "issue": "4",
    "published-print": {
      "date-parts": [
        [
          1950,
          4
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1161/01.CIR.1.4.822"
  ],
  "URL": "http://dx.doi.org/10.1161/01.CIR.1.4.822",
  "relation": {},
  "ISSN": [
    "0009-7322",
    "1524-4539"
  ],
  "subject": [],
  "container-title-short": "Circulation",
  "published": {
    "date-parts": [
      [
        1950,
        4
      ]
    ]
  },
  "assertion": [
    {
      "value": "1950-04-01",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}