Crossref journal-article
S. Karger AG
International Archives of Allergy and Immunology (127)
Abstract

This study utilises a simple technique to section airway epithelium in a plane parallel to the basement membrane, thus providing a unique plan view of the intra-epithelial cell populations. Immunoperoxidase staining of these tissue sections for class II major histocompatibility complex la antigen reveals a virtually contiguous network of Ia-positive dendritic cells (DC) within the epithelium. These DC are shown to be capable of binding inhaled antigens in vivo in a form suitable for presentation to T cells. The strategic location of these cells and the fact that they account for virtually all staining in the airway epithelium during the steady state is convincing evidence that the DC network functions as the ‘first line of defence’ in surveillance for inhaled antigens and further suggests a major role for the intra-epithelial DC in allergic and infectious disease(s) in the respiratory tract.

Bibliography

Holt, P. G., Schon-Hegrad, M. A., Oliver, J., Holt, B. J., & McMenamin, P. G. (1990). A Contiguous Network of Dendritic Antigen-Presenting Cells within the Respiratory Epithelium. International Archives of Allergy and Immunology, 91(2), 155–159. Portico.

Authors 5
  1. Patrick G. Holt (first)
  2. Michael A. Schon-Hegrad (additional)
  3. Jane Oliver (additional)
  4. Barbara J. Holt (additional)
  5. Paul G. McMenamin (additional)
References 0 Referenced 104

None

Dates
Type When
Created 16 years ago (Aug. 7, 2009, 9:46 a.m.)
Deposited 4 months, 1 week ago (April 23, 2025, 6:01 p.m.)
Indexed 3 weeks, 3 days ago (Aug. 6, 2025, 9:32 a.m.)
Issued 35 years, 7 months ago (Jan. 1, 1990)
Published 35 years, 7 months ago (Jan. 1, 1990)
Published Online 16 years ago (Aug. 6, 2009)
Published Print 35 years, 7 months ago (Jan. 1, 1990)
Funders 0

None

@article{Holt_1990, title={A Contiguous Network of Dendritic Antigen-Presenting Cells within the Respiratory Epithelium}, volume={91}, ISSN={1423-0097}, url={http://dx.doi.org/10.1159/000235107}, DOI={10.1159/000235107}, number={2}, journal={International Archives of Allergy and Immunology}, publisher={S. Karger AG}, author={Holt, Patrick G. and Schon-Hegrad, Michael A. and Oliver, Jane and Holt, Barbara J. and McMenamin, Paul G.}, year={1990}, pages={155–159} }