Abstract
This contribution discusses which factors bring about the transformation of epithelium to mesenchyme. Amongst biological agents which have this role are a number of cytokines (e.g. EGF, FGF-1, TGF-β, HGF/SF) and extracellular matrix macromolecules, such as collagens. The coordinated changes in cell morphology, associated with the induction of cell motility and the loss of intercellular junctions, are under the control of signaling molecules that transduce the signal emanating from the plasma membrane, which ultimately lead to changes in gene expression.
Dates
Type | When |
---|---|
Created | 17 years, 1 month ago (July 18, 2008, 10:22 a.m.) |
Deposited | 4 months ago (April 23, 2025, 9:03 p.m.) |
Indexed | 2 months ago (June 26, 2025, 2:25 p.m.) |
Issued | 29 years, 7 months ago (Jan. 1, 1996) |
Published | 29 years, 7 months ago (Jan. 1, 1996) |
Published Online | 17 years, 1 month ago (July 17, 2008) |
Published Print | 29 years, 7 months ago (Jan. 1, 1996) |
@article{Boyer_1996, title={Model Systems of Epithelium Mesenchyme Transitions}, volume={156}, ISSN={1422-6421}, url={http://dx.doi.org/10.1159/000147849}, DOI={10.1159/000147849}, number={3}, journal={Cells Tissues Organs}, publisher={S. Karger AG}, author={Boyer, B. and Vallés, A.M. and Thiery, J.P.}, year={1996}, pages={227–239} }