DOI: 10.1159/000084509. Invasion and Metastasis in Colorectal Cancer: Epithelial-Mesenchymal Transition, Mesenchymal-Epithelial Transition, Stem Cells and β-Catenin

Invasion and Metastasis in Colorectal Cancer: Epithelial-Mesenchymal Transition, Mesenchymal-Epithelial Transition, Stem Cells and β-Catenin

10.1159/000084509

Crossref journal-article

S. Karger AG

Cells Tissues Organs (127)

Abstract

Invasion by colorectal carcinomas is characterized by an epithelial-mesenchymal transition (EMT)-like dedifferentiation of the tumor cells. However, a redifferentiation towards an epithelial phenotype, resembling a mesenchymal-epithelial transition, is detectable in metastases. This indicates that malignant progression is based on dynamic processes, which cannot be explained solely by irreversible genetic alterations, but must be additionally regulated by the tumor environment. The main oncoprotein in colorectal cancer is the Wnt pathway effector β-catenin, which is overexpressed due to mutations in the APC tumor suppressor in most cases. EMT of the tumor cells is associated with a nuclear accumulation of the transcriptional activator β-catenin, which is reversed in metastases. Nuclear β-catenin is involved in two fundamental processes in embryonic development: EMT and stem cell formation. Accumulating data demonstrate that aberrant nuclear expression of β-catenin can also confer these two abilities to tumor cells, thereby driving malignant tumor progression.

Bibliography

Brabletz, T., Hlubek, F., Spaderna, S., Schmalhofer, O., Hiendlmeyer, E., Jung, A., & Kirchner, T. (2005). Invasion and Metastasis in Colorectal Cancer: Epithelial-Mesenchymal Transition, Mesenchymal-Epithelial Transition, Stem Cells and Î²-Catenin. Cells Tissues Organs, 179(1â2), 56â65. Portico.

Authors 7

Thomas Brabletz (first)
Falk Hlubek (additional)
Simone Spaderna (additional)
Otto Schmalhofer (additional)
Elke Hiendlmeyer (additional)
Andreas Jung (additional)
Thomas Kirchner (additional)

References 40 Referenced 428

Dates

Type	When
Created	20 years, 2 months ago (June 7, 2005, 10:20 a.m.)
Deposited	4 months, 1 week ago (April 23, 2025, 11:43 p.m.)
Indexed	1 week, 1 day ago (Aug. 29, 2025, 5:53 a.m.)
Issued	20 years, 8 months ago (Jan. 1, 2005)
Published	20 years, 8 months ago (Jan. 1, 2005)
Published Online	20 years, 3 months ago (June 3, 2005)
Published Print	20 years, 8 months ago (Jan. 1, 2005)

Funders 0

None

BibTeX

@article{Brabletz_2005, title={Invasion and Metastasis in Colorectal Cancer: Epithelial-Mesenchymal Transition, Mesenchymal-Epithelial Transition, Stem Cells and β-Catenin}, volume={179}, ISSN={1422-6421}, url={http://dx.doi.org/10.1159/000084509}, DOI={10.1159/000084509}, number={1–2}, journal={Cells Tissues Organs}, publisher={S. Karger AG}, author={Brabletz, Thomas and Hlubek, Falk and Spaderna, Simone and Schmalhofer, Otto and Hiendlmeyer, Elke and Jung, Andreas and Kirchner, Thomas}, year={2005}, pages={56–65} }

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