DOI: 10.1159/000081738. Early Dynamics of Hepatitis C Virus in the Circulation of Chimpanzees with Experimental Infection

Early Dynamics of Hepatitis C Virus in the Circulation of Chimpanzees with Experimental Infection

10.1159/000081738

Crossref journal-article

S. Karger AG

Intervirology (127)

Abstract

Two chimpanzees were inoculated with hepatitis C virus (HCV) and followed on a daily basis for 12 days. HCV RNA became detectable in their sera on day 5 by polymerase chain reaction with the detection limit of 10<sup>2</sup> copies/ml. Based on an exponential growth observed until 8 or 9 days after inoculation in their sera, the doubling time of HCV in the circulation was estimated at 6.3–8.6 h and log time (time required to grow 10-fold) at 31.3– 42.9 h. The exact doubling time of HCV determined in them would help plan an efficient strategy for screening out blood donors in the window period of infection between the exposure and the development of antibody to HCV in serum.

Bibliography

Tanaka, J., Katayama, K., Kumagai, J., Komiya, Y., Yugi, H., Kishimoto, S., Mizui, M., Tomoguri, T., Miyakawa, Y., & Yoshizawa, H. (2005). Early Dynamics of Hepatitis C Virus in the Circulation of Chimpanzees with Experimental Infection. Intervirology, 48(2â3), 120â123. Portico.

Authors 10

Junko Tanaka (first)
Keiko Katayama (additional)
Junko Kumagai (additional)
Yutaka Komiya (additional)
Hisao Yugi (additional)
Shinya Kishimoto (additional)
Masaaki Mizui (additional)
Tetsushi Tomoguri (additional)
Yuzo Miyakawa (additional)
Hiroshi Yoshizawa (additional)

References 10 Referenced 10

Dates

Type	When
Created	20 years, 5 months ago (April 1, 2005, 3:14 a.m.)
Deposited	4 months, 1 week ago (April 23, 2025, 11:16 p.m.)
Indexed	4 months, 1 week ago (April 25, 2025, 12:09 a.m.)
Issued	20 years, 8 months ago (Jan. 1, 2005)
Published	20 years, 8 months ago (Jan. 1, 2005)
Published Online	20 years, 5 months ago (March 24, 2005)
Published Print	20 years, 8 months ago (Jan. 1, 2005)

Funders 0

None

BibTeX

@article{Tanaka_2005, title={Early Dynamics of Hepatitis C Virus in the Circulation of Chimpanzees with Experimental Infection}, volume={48}, ISSN={1423-0100}, url={http://dx.doi.org/10.1159/000081738}, DOI={10.1159/000081738}, number={2–3}, journal={Intervirology}, publisher={S. Karger AG}, author={Tanaka, Junko and Katayama, Keiko and Kumagai, Junko and Komiya, Yutaka and Yugi, Hisao and Kishimoto, Shinya and Mizui, Masaaki and Tomoguri, Tetsushi and Miyakawa, Yuzo and Yoshizawa, Hiroshi}, year={2005}, pages={120–123} }

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