DOI: 10.1159/000077168. Hippocampal Sclerosis and Ubiquitin-Positive Inclusions in Dementia Lacking Distinctive Histopathology

Hippocampal Sclerosis and Ubiquitin-Positive Inclusions in Dementia Lacking Distinctive Histopathology

10.1159/000077168

Crossref journal-article

S. Karger AG

Dementia and Geriatric Cognitive Disorders (127)

Abstract

The aim of this study was to determine the frequency of ubiquitin-positive inclusions (UPI) in dementia lacking distinctive histology (DLDH), and their relationship to other pathologic features, such as hippocampal sclerosis (HpScl), as well as genetic factors. Routine and immunohistochemical studies were carried out in a consecutive series of 29 cases of DLDH. 83% of the cases had UPI, while HpScl was demonstrated in 76%. There was no significant correlation among pathologic features or between pathologic features and genetic factors. The high prevalence of UPI demonstrated in this study implies that DLDH is similar to motor neuron disease inclusion dementia. The high prevalence of HpScl may be the cause of some of the clinical features observed in patients with frontotemporal lobar degeneration.

Bibliography

Josephs, K. A., Jones, A. G., & Dickson, D. W. (2004). Hippocampal Sclerosis and Ubiquitin-Positive Inclusions in Dementia Lacking Distinctive Histopathology. Dementia and Geriatric Cognitive Disorders, 17(4), 342â345. Portico.

Authors 3

Keith A. Josephs (first)
A.G. Jones (additional)
Dennis W. Dickson (additional)

References 4 Referenced 33

Dates

Type	When
Created	21 years, 2 months ago (June 9, 2004, 3:33 a.m.)
Deposited	4 months, 1 week ago (April 24, 2025, 12:18 a.m.)
Indexed	4 months, 1 week ago (April 24, 2025, 12:40 a.m.)
Issued	21 years, 8 months ago (Jan. 1, 2004)
Published	21 years, 8 months ago (Jan. 1, 2004)
Published Online	21 years, 2 months ago (June 10, 2004)
Published Print	21 years, 8 months ago (Jan. 1, 2004)

Funders 0

None

BibTeX

@article{Josephs_2004, title={Hippocampal Sclerosis and Ubiquitin-Positive Inclusions in Dementia Lacking Distinctive Histopathology}, volume={17}, ISSN={1421-9824}, url={http://dx.doi.org/10.1159/000077168}, DOI={10.1159/000077168}, number={4}, journal={Dementia and Geriatric Cognitive Disorders}, publisher={S. Karger AG}, author={Josephs, Keith A. and Jones, A.G. and Dickson, Dennis W.}, year={2004}, pages={342–345} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        4,
        24
      ]
    ],
    "date-time": "2025-04-24T04:40:11Z",
    "timestamp": 1745469611116,
    "version": "3.40.4"
  },
  "reference-count": 4,
  "publisher": "S. Karger AG",
  "issue": "4",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2004,
            1,
            1
          ]
        ],
        "date-time": "2004-01-01T00:00:00Z",
        "timestamp": 1072915200000
      },
      "content-version": "vor",
      "delay-in-days": 0,
      "URL": "https://www.karger.com/Services/SiteLicenses"
    },
    {
      "start": {
        "date-parts": [
          [
            2004,
            1,
            1
          ]
        ],
        "date-time": "2004-01-01T00:00:00Z",
        "timestamp": 1072915200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.karger.com/Services/SiteLicenses"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2004
      ]
    ]
  },
  "abstract": "<jats:p>The aim of this study was to determine the frequency of ubiquitin-positive inclusions (UPI) in dementia lacking distinctive histology (DLDH), and their relationship to other pathologic features, such as hippocampal sclerosis (HpScl), as well as genetic factors. Routine and immunohistochemical studies were carried out in a consecutive series of 29 cases of DLDH. 83% of the cases had UPI, while HpScl was demonstrated in 76%. There was no significant correlation among pathologic features or between pathologic features and genetic factors. The high prevalence of UPI demonstrated in this study implies that DLDH is similar to motor neuron disease inclusion dementia. The high prevalence of HpScl may be the cause of some of the clinical features observed in patients with frontotemporal lobar degeneration.</jats:p>",
  "DOI": "10.1159/000077168",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        6,
        9
      ]
    ],
    "date-time": "2004-06-09T07:33:23Z",
    "timestamp": 1086766403000
  },
  "page": "342-345",
  "source": "Crossref",
  "is-referenced-by-count": 33,
  "title": "Hippocampal Sclerosis and Ubiquitin-Positive Inclusions in Dementia Lacking Distinctive Histopathology",
  "prefix": "10.1159",
  "volume": "17",
  "author": [
    {
      "given": "Keith A.",
      "family": "Josephs",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "A.G.",
      "family": "Jones",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Dennis W.",
      "family": "Dickson",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "127",
  "published-online": {
    "date-parts": [
      [
        2004,
        6,
        10
      ]
    ]
  },
  "reference": [
    {
      "key": "ref1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/s004010051177"
    },
    {
      "key": "ref2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0165-0270(94)90168-6"
    },
    {
      "key": "ref3",
      "doi-asserted-by": "publisher",
      "DOI": "10.1097/00002093-200210000-00001"
    },
    {
      "key": "ref4",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0140-6736(96)91434-8"
    }
  ],
  "container-title": "Dementia and Geriatric Cognitive Disorders",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.karger.com/Article/Pdf/77168",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://www.karger.com/Article/Pdf/77168",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2025,
        4,
        24
      ]
    ],
    "date-time": "2025-04-24T04:18:32Z",
    "timestamp": 1745468312000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://karger.com/article/doi/10.1159/000077168"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2004
      ]
    ]
  },
  "references-count": 4,
  "journal-issue": {
    "issue": "4",
    "published-online": {
      "date-parts": [
        [
          2004,
          6,
          1
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1159/000077168",
  "relation": {},
  "ISSN": [
    "1420-8008",
    "1421-9824"
  ],
  "subject": [],
  "container-title-short": "Dement Geriatr Cogn Disord",
  "published": {
    "date-parts": [
      [
        2004
      ]
    ]
  }
}