DOI: 10.1158/1055-9965.epi-06-0352. Prolonged Prevention of Squamous Cell Carcinoma of the Skin by Regular Sunscreen Use

Prolonged Prevention of Squamous Cell Carcinoma of the Skin by Regular Sunscreen Use

10.1158/1055-9965.epi-06-0352

Crossref journal-article

American Association for Cancer Research (AACR)

Cancer Epidemiology, Biomarkers & Prevention (1086)

Abstract

Abstract Half of all cancers in the United States are skin cancers. We have previously shown in a 4.5-year randomized controlled trial in an Australian community that squamous cell carcinomas (SCC) but not basal cell carcinomas (BCC) can be prevented by regular sunscreen application to the head, neck, hands, and forearms. Since cessation of the trial, we have followed participants for a further 8 years to evaluate possible latency of preventive effect on BCCs and SCCs. After prolonged follow-up, BCC tumor rates tended to decrease but not significantly in people formerly randomized to daily sunscreen use compared with those not applying sunscreen daily. By contrast, corresponding SCC tumor rates were significantly decreased by almost 40% during the entire follow-up period (rate ratio, 0.62; 95% confidence interval, 0.38-0.99). Regular application of sunscreen has prolonged preventive effects on SCC but with no clear benefit in reducing BCC. (Cancer Epidemiol Biomarkers Prev 2006;15(12):2546–8)

Bibliography

van der Pols, J. C., Williams, G. M., Pandeya, N., Logan, V., & Green, A. C. (2006). Prolonged Prevention of Squamous Cell Carcinoma of the Skin by Regular Sunscreen Use. Cancer Epidemiology, Biomarkers & Prevention, 15(12), 2546â2548.

Authors 5

Jolieke C. van der Pols (first)
Gail M. Williams (additional)
Nirmala Pandeya (additional)
Valerie Logan (additional)
Adèle C. Green (additional)

References 13 Referenced 307

Dates

Type	When
Created	18 years, 8 months ago (Dec. 13, 2006, 9:48 a.m.)
Deposited	3 years, 2 months ago (June 10, 2022, 9:46 a.m.)
Indexed	3 days, 15 hours ago (Aug. 21, 2025, 1:48 p.m.)
Issued	18 years, 8 months ago (Dec. 1, 2006)
Published	18 years, 8 months ago (Dec. 1, 2006)
Published Online	18 years, 8 months ago (Dec. 12, 2006)
Published Print	18 years, 8 months ago (Dec. 1, 2006)

Funders 0

None

BibTeX

@article{van_der_Pols_2006, title={Prolonged Prevention of Squamous Cell Carcinoma of the Skin by Regular Sunscreen Use}, volume={15}, ISSN={1538-7755}, url={http://dx.doi.org/10.1158/1055-9965.epi-06-0352}, DOI={10.1158/1055-9965.epi-06-0352}, number={12}, journal={Cancer Epidemiology, Biomarkers & Prevention}, publisher={American Association for Cancer Research (AACR)}, author={van der Pols, Jolieke C. and Williams, Gail M. and Pandeya, Nirmala and Logan, Valerie and Green, Adèle C.}, year={2006}, month=dec, pages={2546–2548} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        21
      ]
    ],
    "date-time": "2025-08-21T17:48:20Z",
    "timestamp": 1755798500603
  },
  "reference-count": 13,
  "publisher": "American Association for Cancer Research (AACR)",
  "issue": "12",
  "content-domain": {
    "domain": [
      "aacrjournals.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        2006,
        12,
        1
      ]
    ]
  },
  "abstract": "<jats:title>Abstract</jats:title>\n               <jats:p>Half of all cancers in the United States are skin cancers. We have previously shown in a 4.5-year randomized controlled trial in an Australian community that squamous cell carcinomas (SCC) but not basal cell carcinomas (BCC) can be prevented by regular sunscreen application to the head, neck, hands, and forearms. Since cessation of the trial, we have followed participants for a further 8 years to evaluate possible latency of preventive effect on BCCs and SCCs. After prolonged follow-up, BCC tumor rates tended to decrease but not significantly in people formerly randomized to daily sunscreen use compared with those not applying sunscreen daily. By contrast, corresponding SCC tumor rates were significantly decreased by almost 40% during the entire follow-up period (rate ratio, 0.62; 95% confidence interval, 0.38-0.99). Regular application of sunscreen has prolonged preventive effects on SCC but with no clear benefit in reducing BCC. (Cancer Epidemiol Biomarkers Prev 2006;15(12):2546\u20138)</jats:p>",
  "DOI": "10.1158/1055-9965.epi-06-0352",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        12,
        13
      ]
    ],
    "date-time": "2006-12-13T14:48:02Z",
    "timestamp": 1166021282000
  },
  "page": "2546-2548",
  "update-policy": "http://dx.doi.org/10.1158/crossmark_policy",
  "source": "Crossref",
  "is-referenced-by-count": 307,
  "title": "Prolonged Prevention of Squamous Cell Carcinoma of the Skin by Regular Sunscreen Use",
  "prefix": "10.1158",
  "volume": "15",
  "author": [
    {
      "given": "Jolieke C.",
      "family": "van der Pols",
      "sequence": "first",
      "affiliation": [
        {
          "name": "1Longitudinal Studies Unit, School of Population Health, University of Queensland and"
        },
        {
          "name": "2Cancer and Population Studies Unit, Queensland Institute of Medical Research, Brisbane, Queensland, Australia"
        }
      ]
    },
    {
      "given": "Gail M.",
      "family": "Williams",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "1Longitudinal Studies Unit, School of Population Health, University of Queensland and"
        }
      ]
    },
    {
      "given": "Nirmala",
      "family": "Pandeya",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "2Cancer and Population Studies Unit, Queensland Institute of Medical Research, Brisbane, Queensland, Australia"
        }
      ]
    },
    {
      "given": "Valerie",
      "family": "Logan",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "2Cancer and Population Studies Unit, Queensland Institute of Medical Research, Brisbane, Queensland, Australia"
        }
      ]
    },
    {
      "given": "Ade\u0300le C.",
      "family": "Green",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "2Cancer and Population Studies Unit, Queensland Institute of Medical Research, Brisbane, Queensland, Australia"
        }
      ]
    }
  ],
  "member": "1086",
  "published-online": {
    "date-parts": [
      [
        2006,
        12,
        12
      ]
    ]
  },
  "reference": [
    {
      "key": "2022061002382157100_BIB1",
      "doi-asserted-by": "crossref",
      "unstructured": "Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2006. CA Cancer J Clin\u20082006;56:106\u201330.",
      "DOI": "10.3322/canjclin.56.2.106"
    },
    {
      "key": "2022061002382157100_BIB2",
      "doi-asserted-by": "crossref",
      "unstructured": "Joseph AK, Mark TL, Mueller C. The period prevalence and costs of treating nonmelanoma skin cancers in patients over 65 years of age covered by medicare. Dermatol Surg\u20082001;27:955\u20139.",
      "DOI": "10.1046/j.1524-4725.2001.01106.x"
    },
    {
      "key": "2022061002382157100_BIB3",
      "doi-asserted-by": "crossref",
      "unstructured": "Task Force on Community Preventive Services. Recommendations to prevent skin cancer by reducing exposure to ultraviolet radiation. Am J Prev Med\u20082004;27:467\u201370.",
      "DOI": "10.1016/S0749-3797(04)00199-0"
    },
    {
      "key": "2022061002382157100_BIB4",
      "doi-asserted-by": "crossref",
      "unstructured": "Darlington S, Williams G, Neale R, Frost C, Green A. A randomized controlled trial to assess sunscreen application and beta carotene supplementation in the prevention of solar keratoses. Arch Dermatol\u20082003;139:451\u20135.",
      "DOI": "10.1001/archderm.139.4.451"
    },
    {
      "key": "2022061002382157100_BIB5",
      "doi-asserted-by": "crossref",
      "unstructured": "Green A, Williams G, Neale R, et al. Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trial. Lancet\u20081999;354:723\u20139. Erratum: Lancet 1999;354:1038.",
      "DOI": "10.1016/S0140-6736(98)12168-2"
    },
    {
      "key": "2022061002382157100_BIB6",
      "doi-asserted-by": "crossref",
      "unstructured": "Pandeya N, Purdie DM, Green A, Williams G. Repeated occurrence of basal cell carcinoma of the skin and multifailure survival analysis: follow-up data from the Nambour Skin Cancer Prevention Trial. Am J Epidemiol\u20082005;161:748\u201354.",
      "DOI": "10.1093/aje/kwi098"
    },
    {
      "key": "2022061002382157100_BIB7",
      "doi-asserted-by": "crossref",
      "unstructured": "van der Pols JC, Williams GM, Neale RE, Clavarino A, Green AC. Long-term increase in sunscreen use in an Australian community after a skin cancer prevention trial. Prev Med\u20082006;42:171\u20136.",
      "DOI": "10.1016/j.ypmed.2005.10.007"
    },
    {
      "key": "2022061002382157100_BIB8",
      "doi-asserted-by": "crossref",
      "unstructured": "Green AC, Williams GM, Neale RE, Battistutta D. Beta-carotene and sunscreen use: authors' reply. Lancet\u20081999;354:2163\u20134.",
      "DOI": "10.1016/S0140-6736(05)77065-3"
    },
    {
      "key": "2022061002382157100_BIB9",
      "doi-asserted-by": "crossref",
      "unstructured": "Matsuoka LY, Ide L, Wortsman J, MacLaughlin JA, Holick MF. Sunscreens suppress cutaneous vitamin D3 synthesis. J Clin Endocrinol Metab\u20081987;64:1165\u20138.",
      "DOI": "10.1210/jcem-64-6-1165"
    },
    {
      "key": "2022061002382157100_BIB10",
      "doi-asserted-by": "crossref",
      "unstructured": "Sollitto RB, Kraemer KH, DiGiovanna JJ. Normal vitamin D levels can be maintained despite rigorous photoprotection: six years' experience with xeroderma pigmentosum. J Am Acad Dermatol\u20081997;37:942\u20137.",
      "DOI": "10.1016/S0190-9622(97)70069-0"
    },
    {
      "key": "2022061002382157100_BIB11",
      "doi-asserted-by": "crossref",
      "unstructured": "Farrerons J, Barnadas M, Rodriguez J, et al. Clinically prescribed sunscreen (sun protection factor 15) does not decrease serum vitamin D concentration sufficiently either to induce changes in parathyroid function or in metabolic markers. Br J Dermatol\u20081998;139:422\u20137.",
      "DOI": "10.1046/j.1365-2133.1998.02405.x"
    },
    {
      "key": "2022061002382157100_BIB12",
      "doi-asserted-by": "crossref",
      "unstructured": "Autier P, Dore JF, Negrier S, et al. Sunscreen use and duration of sun exposure: a double-blind, randomized trial. J Natl Cancer Inst\u20081999;91:1304\u20139.",
      "DOI": "10.1093/jnci/91.15.1304"
    },
    {
      "key": "2022061002382157100_BIB13",
      "doi-asserted-by": "crossref",
      "unstructured": "Dupuy A, Dunant A, Grob JJ. Randomized controlled trial testing the impact of high-protection sunscreens on sun-exposure behavior. Arch Dermatol\u20082005;141:950\u20136.",
      "DOI": "10.1001/archderm.141.8.950"
    }
  ],
  "container-title": "Cancer Epidemiology, Biomarkers &amp; Prevention",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://aacrjournals.org/cebp/article-pdf/15/12/2546/2264413/2546.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "syndication"
    },
    {
      "URL": "https://aacrjournals.org/cebp/article-pdf/15/12/2546/2264413/2546.pdf",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2022,
        6,
        10
      ]
    ],
    "date-time": "2022-06-10T13:46:07Z",
    "timestamp": 1654868767000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://aacrjournals.org/cebp/article/15/12/2546/264468/Prolonged-Prevention-of-Squamous-Cell-Carcinoma-of"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2006,
        12,
        1
      ]
    ]
  },
  "references-count": 13,
  "journal-issue": {
    "issue": "12",
    "published-online": {
      "date-parts": [
        [
          2006,
          12,
          12
        ]
      ]
    },
    "published-print": {
      "date-parts": [
        [
          2006,
          12,
          1
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1158/1055-9965.EPI-06-0352",
  "relation": {},
  "ISSN": [
    "1055-9965",
    "1538-7755"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        2006,
        12,
        1
      ]
    ]
  }
}