DOI: 10.1158/0008-5472.can-07-1083. The <i>let-7</i> MicroRNA Represses Cell Proliferation Pathways in Human Cells

The let-7 MicroRNA Represses Cell Proliferation Pathways in Human Cells

10.1158/0008-5472.can-07-1083

Crossref journal-article

American Association for Cancer Research (AACR)

Cancer Research (1086)

Abstract

Abstract MicroRNAs play important roles in animal development, cell differentiation, and metabolism and have been implicated in human cancer. The let-7 microRNA controls the timing of cell cycle exit and terminal differentiation in Caenorhabditis elegans and is poorly expressed or deleted in human lung tumors. Here, we show that let-7 is highly expressed in normal lung tissue, and that inhibiting let-7 function leads to increased cell division in A549 lung cancer cells. Overexpression of let-7 in cancer cell lines alters cell cycle progression and reduces cell division, providing evidence that let-7 functions as a tumor suppressor in lung cells. let-7 was previously shown to regulate the expression of the RAS lung cancer oncogenes, and our work now shows that multiple genes involved in cell cycle and cell division functions are also directly or indirectly repressed by let-7. This work reveals the let-7 microRNA to be a master regulator of cell proliferation pathways. [Cancer Res 2007;67(16):7713–22]

Bibliography

Johnson, C. D., Esquela-Kerscher, A., Stefani, G., Byrom, M., Kelnar, K., Ovcharenko, D., Wilson, M., Wang, X., Shelton, J., Shingara, J., Chin, L., Brown, D., & Slack, F. J. (2007). The let-7 MicroRNA Represses Cell Proliferation Pathways in Human Cells. Cancer Research, 67(16), 7713â7722.

Authors 13

Charles D. Johnson (first)
Aurora Esquela-Kerscher (additional)
Giovanni Stefani (additional)
Mike Byrom (additional)
Kevin Kelnar (additional)
Dmitriy Ovcharenko (additional)
Mike Wilson (additional)
Xiaowei Wang (additional)
Jeffrey Shelton (additional)
Jaclyn Shingara (additional)
Lena Chin (additional)
David Brown (additional)
Frank J. Slack (additional)

References 48 Referenced 1,033

Dates

Type	When
Created	18 years ago (Aug. 15, 2007, 3:18 p.m.)
Deposited	3 years, 2 months ago (June 16, 2022, 11:52 p.m.)
Indexed	1 day, 22 hours ago (Sept. 4, 2025, 9:49 a.m.)
Issued	18 years ago (Aug. 15, 2007)
Published	18 years ago (Aug. 15, 2007)
Published Online	18 years ago (Aug. 15, 2007)
Published Print	18 years ago (Aug. 15, 2007)

Funders 0

None

BibTeX

@article{Johnson_2007, title={The let-7 MicroRNA Represses Cell Proliferation Pathways in Human Cells}, volume={67}, ISSN={1538-7445}, url={http://dx.doi.org/10.1158/0008-5472.can-07-1083}, DOI={10.1158/0008-5472.can-07-1083}, number={16}, journal={Cancer Research}, publisher={American Association for Cancer Research (AACR)}, author={Johnson, Charles D. and Esquela-Kerscher, Aurora and Stefani, Giovanni and Byrom, Mike and Kelnar, Kevin and Ovcharenko, Dmitriy and Wilson, Mike and Wang, Xiaowei and Shelton, Jeffrey and Shingara, Jaclyn and Chin, Lena and Brown, David and Slack, Frank J.}, year={2007}, month=aug, pages={7713–7722} }

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