DOI: 10.1158/0008-5472.can-04-1853. Macrophages Promote the Invasion of Breast Carcinoma Cells via a Colony-Stimulating Factor-1/Epidermal Growth Factor Paracrine Loop

Macrophages Promote the Invasion of Breast Carcinoma Cells via a Colony-Stimulating Factor-1/Epidermal Growth Factor Paracrine Loop

10.1158/0008-5472.can-04-1853

Crossref journal-article

American Association for Cancer Research (AACR)

Cancer Research (1086)

Abstract

Abstract Previous studies have shown that macrophages and tumor cells are comigratory in mammary tumors and that these cell types are mutually dependent for invasion. Here we show that macrophages and tumor cells are necessary and sufficient for comigration and invasion into collagen I and that this process involves a paracrine loop. Macrophages express epidermal growth factor (EGF), which promotes the formation of elongated protrusions and cell invasion by carcinoma cells. Colony stimulating factor 1 (CSF-1) produced by carcinoma cells promotes the expression of EGF by macrophages. In addition, EGF promotes the expression of CSF-1 by carcinoma cells thereby generating a positive feedback loop. Disruption of this loop by blockade of either EGF receptor or CSF-1 receptor signaling is sufficient to inhibit both macrophage and tumor cell migration and invasion.

Bibliography

Goswami, S., Sahai, E., Wyckoff, J. B., Cammer, M., Cox, D., Pixley, F. J., Stanley, E. R., Segall, J. E., & Condeelis, J. S. (2005). Macrophages Promote the Invasion of Breast Carcinoma Cells via a Colony-Stimulating Factor-1/Epidermal Growth Factor Paracrine Loop. Cancer Research, 65(12), 5278â5283.

Authors 9

Sumanta Goswami (first)
Erik Sahai (additional)
Jeffrey B. Wyckoff (additional)
Michael Cammer (additional)
Dianne Cox (additional)
Fiona J. Pixley (additional)
E. Richard Stanley (additional)
Jeffrey E. Segall (additional)
John S. Condeelis (additional)

References 24 Referenced 593

Dates

Type	When
Created	19 years, 11 months ago (Sept. 15, 2005, 5:53 p.m.)
Deposited	3 years, 2 months ago (June 16, 2022, 4:40 p.m.)
Indexed	5 days, 8 hours ago (Aug. 31, 2025, 7:18 p.m.)
Issued	20 years, 2 months ago (June 15, 2005)
Published	20 years, 2 months ago (June 15, 2005)
Published Online	20 years, 2 months ago (June 15, 2005)
Published Print	20 years, 2 months ago (June 15, 2005)

Funders 0

None

BibTeX

@article{Goswami_2005, title={Macrophages Promote the Invasion of Breast Carcinoma Cells via a Colony-Stimulating Factor-1/Epidermal Growth Factor Paracrine Loop}, volume={65}, ISSN={1538-7445}, url={http://dx.doi.org/10.1158/0008-5472.can-04-1853}, DOI={10.1158/0008-5472.can-04-1853}, number={12}, journal={Cancer Research}, publisher={American Association for Cancer Research (AACR)}, author={Goswami, Sumanta and Sahai, Erik and Wyckoff, Jeffrey B. and Cammer, Michael and Cox, Dianne and Pixley, Fiona J. and Stanley, E. Richard and Segall, Jeffrey E. and Condeelis, John S.}, year={2005}, month=jun, pages={5278–5283} }

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