DOI: 10.1158/0008-5472.can-03-2031. Accelerated Induction of Bladder Cancer in <b> <i>Patched</i> </b> Heterozygous Mutant Mice

Accelerated Induction of Bladder Cancer in Patched Heterozygous Mutant Mice

10.1158/0008-5472.can-03-2031

Crossref journal-article

American Association for Cancer Research (AACR)

Cancer Research (1086)

Abstract

Abstract The PATCHED (PTC) gene is recognized as a tumor suppressor in basal cell carcinoma. Mapping of a minimal region of deletion at 9q22.3 and observation of a decreased PTC expression in superficial papillary bladder tumors led us to hypothesize that it could also be involved in this cancer. To further investigate this hypothesis, we submitted Ptc+/− heterozygous mutant mice and their wild-type littermates to chemical carcinogenesis by adding N-butyl-N-(4-hydroxybutyl) nitrosamine to their drinking water. Preneoplastic and neoplastic changes were observed significantly earlier in the Ptc+/− than in the wild-type mice. Our data support the hypothesis of Ptc acting as a tumor suppressor gene in bladder cancer.

Bibliography

Hamed, S., LaRue, H., Hovington, H., Girard, J., Jeannotte, L., Latulippe, E., & Fradet, Y. (2004). Accelerated Induction of Bladder Cancer in Patched Heterozygous Mutant Mice. Cancer Research, 64(6), 1938â1942.

Authors 7

Sahar Hamed (first)
Hélène LaRue (additional)
Hélène Hovington (additional)
Johanne Girard (additional)
Lucie Jeannotte (additional)
Eva Latulippe (additional)
Yves Fradet (additional)

References 20 Referenced 17

Knowles MA. The genetics of transitional cell carcinoma: progress and potential clinical application. BJU Int, 84: 412-27, 1999. (10.1046/j.1464-410x.1999.00217.x)
Simoneau M, Aboulkassim TO, Larue H, Rousseau F, Fradet Y. Four tumor suppressor loci on chromosome 9q in bladder cancer: evidence for two novel candidate regions at 9q22.3 and 9q31. Oncogene, 18: 157-63, 1999. (10.1038/sj.onc.1202277)
Aboulkassim TO, Larue H, Lemieux P, Rousseau F, Fradet Y. Alteration of the Patched locus in superficial bladder cancer. Oncogene, 22: 2967-71, 2003. (10.1038/sj.onc.1206513)
Simoneau M, Larue H, Aboulkassim TO, Meyer F, Moore L, Fradet Y. Chromosome 9 deletions and recurrence of superficial bladder cancer: identification of four regions of prognostic interest. Oncogene, 19: 6317-23, 2000. (10.1038/sj.onc.1204022)
Bale AE, Yu KP. The hedgehog pathway and basal cell carcinomas. Hum Mol Genet, 10: 757-62, 2001. (10.1093/hmg/10.7.757)
Zurawel RH, Allen C, Chiappa S, et al Analysis of PTCH/SMO/SHH pathway genes in medulloblastoma. Genes Chromosomes Cancer, 27: 44-51, 2000. (10.1002/(SICI)1098-2264(200001)27:1<44::AID-GCC6>3.0.CO;2-V)
Goodrich LV, Milenkovic L, Higgins KM, Scott MP. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science (Wash. DC), 277: 1109-13, 1997. (10.1126/science.277.5329.1109)
Aszterbaum M, Epstein J, Oro A, et al Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. Nat Med, 5: 1285-91, 1999. (10.1038/15242)
Ohtani M, Kakizoe T, Nishio Y, et al Sequential changes of mouse bladder epithelium during induction of invasive carcinomas by N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Res, 46: 2001-4, 1986.
Hard GC, Durchfeld-Meyer B, Short B, et al Urinary system Mohr U eds. . International classification of rodent tumors: the mouse, p. 139-62, Springer-Verlag New York 2001. (10.1007/978-3-662-07973-7_5)
Dunn SE, Kari FW, French J, et al Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice. Cancer Res, 57: 4667-72, 1997.
Aubin J, Dery U, Lemieux M, Chailler P, Jeannotte L. Stomach regional specification requires Hoxa5-driven mesenchymal-epithelial signaling. Development (Camb.), 129: 4075-87, 2002. (10.1242/dev.129.17.4075)
Gavrieli Y, Sherman Y, Ben Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol, 119: 493-501, 1992. (10.1083/jcb.119.3.493)
Halliwell WH. Submucosal mesenchymal tumors of the mouse urinary bladder. Toxicol Pathol, 26: 128-36, 1998. (10.1177/019262339802600115)
Hendzel MJ, Wei Y, Mancini MA, et al Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma (Berl.), 106: 348-60, 1997. (10.1007/s004120050256)
Takaba K, Saeki K, Suzuki K, Wanibuchi H, Fukushima S. Significant overexpression of metallothionein and cyclin D1 and apoptosis in the early process of rat urinary bladder carcinogenesis induced by treatment with N-butyl-N-(4-hydroxybutyl)nitrosamine or sodium L-ascorbate. Carcinogenesis (Lond.), 21: 691-700, 2000. (10.1093/carcin/21.4.691)
Saldanha G. The Hedgehog signalling pathway and cancer. J Pathol, 193: 427-32, 2001. (10.1002/1096-9896(2000)9999:9999<::AID-PATH815>3.0.CO;2-N)
Marigo V, Davey RA, Zuo Y, Cunningham JM, Tabin CJ. Biochemical evidence that patched is the Hedgehog receptor[see comments]. Nature (Lond.), 384: 176-9, 1996. (10.1038/384176a0)
Wicking C, Smyth I, Bale A. The hedgehog signalling pathway in tumorigenesis and development. Oncogene, 18: 7844-51, 1999. (10.1038/sj.onc.1203282)
Ozaki K, Sukata T, Yamamoto S, et al High susceptibility of p53(+/−) knockout mice in N-butyl-N-(4-hydroxybutyl)nitrosamine urinary bladder carcinogenesis and lack of frequent mutation in residual allele. Cancer Res, 58: 3806-11, 1998.

Dates

Type	When
Created	19 years, 11 months ago (Sept. 20, 2005, 6:37 p.m.)
Deposited	3 years, 2 months ago (June 16, 2022, 5:01 p.m.)
Indexed	1 year, 1 month ago (July 10, 2024, 1:07 a.m.)
Issued	21 years, 5 months ago (March 15, 2004)
Published	21 years, 5 months ago (March 15, 2004)
Published Online	21 years, 5 months ago (March 16, 2004)
Published Print	21 years, 5 months ago (March 15, 2004)

Funders 0

None

BibTeX

@article{Hamed_2004, title={Accelerated Induction of Bladder Cancer in Patched Heterozygous Mutant Mice}, volume={64}, ISSN={1538-7445}, url={http://dx.doi.org/10.1158/0008-5472.can-03-2031}, DOI={10.1158/0008-5472.can-03-2031}, number={6}, journal={Cancer Research}, publisher={American Association for Cancer Research (AACR)}, author={Hamed, Sahar and LaRue, Hélène and Hovington, Hélène and Girard, Johanne and Jeannotte, Lucie and Latulippe, Eva and Fradet, Yves}, year={2004}, month=mar, pages={1938–1942} }

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