DOI: 10.1155/s1110724302202016. Answering the Call: Coping with DNA Damage at the Most Inopportune Time

Answering the Call: Coping with DNA Damage at the Most Inopportune Time

10.1155/s1110724302202016

Crossref journal-article

Wiley

BioMed Research International (311)

Abstract

DNA damage incurred during the process of chromosomal replication has a particularly high possibility of resulting in mutagenesis or lethality for the cell. The SOS response of Escherichia coli appears to be well adapted for this particular situation and involves the coordinated up‐regulation of genes whose products center upon the tasks of maintaining the integrity of the replication fork when it encounters DNA damage, delaying the replication process (a DNA damage checkpoint), repairing the DNA lesions or allowing replication to occur over these DNA lesions, and then restoring processive replication before the SOS response itself is turned off. Recent advances in the fields of genomics and biochemistry has given a much more comprehensive picture of the timing and coordination of events which allow cells to deal with potentially lethal or mutagenic DNA lesions at the time of chromosomal replication.

Bibliography

Crowley, D. J., & Courcelle, J. (2002). Answering the Call: Coping with DNA Damage at the Most Inopportune Time. BioMed Research International, 2(2), 66â74. Portico.

Authors 2

David J. Crowley (first)
Justin Courcelle (additional)

References 0 Referenced 17

None

Dates

Type	When
Created	22 years, 10 months ago (Sept. 29, 2002, 2:36 p.m.)
Deposited	1 year ago (July 30, 2024, 2:20 a.m.)
Indexed	1 year ago (Aug. 12, 2024, 7:15 a.m.)
Issued	23 years, 7 months ago (Jan. 1, 2002)
Published	23 years, 7 months ago (Jan. 1, 2002)
Published Online	22 years, 8 months ago (Dec. 10, 2002)
Published Print	23 years, 7 months ago (Jan. 1, 2002)

Funders 1

National Natural Science Foundation of China 10.13039/501100001809
Region: Asia
gov (National government)
Labels11
1. Chinese National Science Foundation
2. Natural Science Foundation of China
3. National Science Foundation of China
4. NNSF of China
5. NSF of China
6. 国家自然科学基金委员会
7. National Nature Science Foundation of China
8. Guójiā Zìrán Kēxué Jījīn Wěiyuánhuì
9. NSFC
10. NNSF
11. NNSFC
Awards1
1. MCB0130486

BibTeX

@article{Crowley_2002, title={Answering the Call: Coping with DNA Damage at the Most Inopportune Time}, volume={2}, ISSN={2314-6141}, url={http://dx.doi.org/10.1155/s1110724302202016}, DOI={10.1155/s1110724302202016}, number={2}, journal={BioMed Research International}, publisher={Wiley}, author={Crowley, David J. and Courcelle, Justin}, year={2002}, month=jan, pages={66–74} }

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