DOI: 10.1155/mbd.1997.9. Antitumour Activity of a pt(III) Derivative of 2‐Mercaptopyrimidine

Antitumour Activity of a pt(III) Derivative of 2‐Mercaptopyrimidine

10.1155/mbd.1997.9

Crossref journal-article

Wiley

Metal-Based Drugs (311)

Abstract

The complex [Pt2Cl2(Spym)4], where Spym = 2‐mercaptopyrimidine, was synthesized and analyzed spectroscopically. The presence in the 195Pt NMR spectrum, of only one signal for the Pt(III) indicates the symmetrical arrangement of the ligands and the identical setting of N, S and Cl atoms, PtS2ClN2, for the two Pt atoms being different to other compounds described in the literature. The interaction of this complex with DNA was studied by several techniques, including circular dichroism, melting temperature determination, electron microscopy (EM) and atomic force microscopy (TMAFM). Preliminary results show a high activity against HL‐60 and HeLa tumour lines for the Pt‐2‐mercaptopyrimidine complex in comparison with cisplatin activity. Higher values for IC50 were obtained, while the values of LD50 were lower than those for cisplatin.

Bibliography

Cervantes, G., Prieto, M. J., & Moreno, V. (1997). Antitumour Activity of a pt(III) Derivative of 2âMercaptopyrimidine. Metal-Based Drugs, 4(1), 9â18. Portico.

Authors 3

G. Cervantes (first)
M. J. Prieto (additional)
V. Moreno (additional)

References 0 Referenced 41

None

Dates

Type	When
Created	18 years, 5 months ago (March 14, 2007, 8:33 a.m.)
Deposited	1 year ago (Aug. 8, 2024, 11:11 a.m.)
Indexed	1 year ago (Aug. 8, 2024, 12:10 p.m.)
Issued	28 years, 8 months ago (Jan. 1, 1997)
Published	28 years, 8 months ago (Jan. 1, 1997)
Published Online	28 years, 7 months ago (Jan. 21, 1997)
Published Print	28 years, 8 months ago (Jan. 1, 1997)

Funders 0

None

BibTeX

@article{Cervantes_1997, title={Antitumour Activity of a pt(III) Derivative of 2‐Mercaptopyrimidine}, volume={4}, ISSN={1687-5486}, url={http://dx.doi.org/10.1155/mbd.1997.9}, DOI={10.1155/mbd.1997.9}, number={1}, journal={Metal-Based Drugs}, publisher={Wiley}, author={Cervantes, G. and Prieto, M. J. and Moreno, V.}, year={1997}, month=jan, pages={9–18} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        8,
        8
      ]
    ],
    "date-time": "2024-08-08T16:10:05Z",
    "timestamp": 1723133405161
  },
  "reference-count": 0,
  "publisher": "Wiley",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2000,
            1,
            1
          ]
        ],
        "date-time": "2000-01-01T00:00:00Z",
        "timestamp": 946684800000
      },
      "content-version": "vor",
      "delay-in-days": 1095,
      "URL": "http://creativecommons.org/licenses/by/3.0/"
    }
  ],
  "content-domain": {
    "domain": [
      "onlinelibrary.wiley.com"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1997,
        1
      ]
    ]
  },
  "abstract": "<jats:p>The complex [Pt<jats:sub>2</jats:sub>Cl<jats:sub>2</jats:sub>(Spym)<jats:sub>4</jats:sub>], where Spym = 2\u2010mercaptopyrimidine, was synthesized and\nanalyzed spectroscopically. The presence in the <jats:sub>\u2009</jats:sub><jats:sup>195</jats:sup>Pt NMR spectrum, of only one signal for the Pt(III) indicates the symmetrical arrangement of the ligands and the identical setting of N, S and Cl atoms, PtS<jats:sub>2</jats:sub>ClN<jats:sub>2</jats:sub>, for the two Pt atoms being different to other compounds described in the\nliterature. The interaction of this complex with DNA was studied by several techniques, including circular dichroism, melting temperature determination, electron microscopy (EM) and atomic force\nmicroscopy (TMAFM). Preliminary results show a high activity against HL\u201060 and HeLa tumour lines for the Pt\u20102\u2010mercaptopyrimidine complex in comparison with <jats:italic>cisplatin</jats:italic> activity. Higher values for IC<jats:sub>50</jats:sub> were obtained, while the values of LD<jats:sub>50</jats:sub> were lower than those for <jats:italic>cisplatin</jats:italic>.</jats:p>",
  "DOI": "10.1155/mbd.1997.9",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2007,
        3,
        14
      ]
    ],
    "date-time": "2007-03-14T12:33:53Z",
    "timestamp": 1173875633000
  },
  "page": "9-18",
  "update-policy": "http://dx.doi.org/10.1002/crossmark_policy",
  "source": "Crossref",
  "is-referenced-by-count": 41,
  "title": "Antitumour Activity of a pt(III) Derivative of 2\u2010Mercaptopyrimidine",
  "prefix": "10.1155",
  "volume": "4",
  "author": [
    {
      "given": "G.",
      "family": "Cervantes",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "M. J.",
      "family": "Prieto",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "V.",
      "family": "Moreno",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        1997,
        1,
        21
      ]
    ]
  },
  "container-title": "Metal-Based Drugs",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://downloads.hindawi.com/archive/1997/489768.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://onlinelibrary.wiley.com/doi/pdf/10.1155/MBD.1997.9",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        8,
        8
      ]
    ],
    "date-time": "2024-08-08T15:11:47Z",
    "timestamp": 1723129907000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://onlinelibrary.wiley.com/doi/10.1155/MBD.1997.9"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1997,
        1
      ]
    ]
  },
  "references-count": 0,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          1997,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1155/MBD.1997.9"
  ],
  "URL": "http://dx.doi.org/10.1155/MBD.1997.9",
  "relation": {},
  "ISSN": [
    "0793-0291",
    "1687-5486"
  ],
  "subject": [],
  "container-title-short": "Metal-Based Drugs",
  "published": {
    "date-parts": [
      [
        1997,
        1
      ]
    ]
  },
  "assertion": [
    {
      "value": "1997-01-03",
      "order": 0,
      "name": "received",
      "label": "Received",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    },
    {
      "value": "1997-01-21",
      "order": 2,
      "name": "accepted",
      "label": "Accepted",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    },
    {
      "value": "1997-01-21",
      "order": 3,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}