DOI: 10.1155/2012/428010. Mechanism of Oxidative Stress in Neurodegeneration

Mechanism of Oxidative Stress in Neurodegeneration

10.1155/2012/428010

Crossref journal-article

Hindawi Limited

Oxidative Medicine and Cellular Longevity (98)

Abstract

Biological tissues require oxygen to meet their energetic demands. However, the consumption of oxygen also results in the generation of free radicals that may have damaging effects on cells. The brain is particularly vulnerable to the effects of reactive oxygen species due to its high demand for oxygen, and its abundance of highly peroxidisable substrates. Oxidative stress is caused by an imbalance in the redox state of the cell, either by overproduction of reactive oxygen species, or by dysfunction of the antioxidant systems. Oxidative stress has been detected in a range of neurodegenerative disease, and emerging evidence from in vitro and in vivo disease models suggests that oxidative stress may play a role in disease pathogenesis. However, the promise of antioxidants as novel therapies for neurodegenerative diseases has not been borne out in clinical studies. In this review, we critically assess the hypothesis that oxidative stress is a crucial player in common neurodegenerative disease and discuss the source of free radicals in such diseases. Furthermore, we examine the issues surrounding the failure to translate this hypothesis into an effective clinical treatment.

Bibliography

Gandhi, S., & Abramov, A. Y. (2012). Mechanism of Oxidative Stress in Neurodegeneration. Oxidative Medicine and Cellular Longevity, 2012, 1â11.

Authors 2

Sonia Gandhi (first)
Andrey Y. Abramov (additional)

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Dates

Type	When
Created	13 years, 3 months ago (May 17, 2012, 8:27 a.m.)
Deposited	1 year, 4 months ago (April 24, 2024, 12:43 p.m.)
Indexed	1 day, 13 hours ago (Aug. 24, 2025, 6:53 p.m.)
Issued	13 years, 7 months ago (Jan. 1, 2012)
Published	13 years, 7 months ago (Jan. 1, 2012)
Published Print	13 years, 7 months ago (Jan. 1, 2012)

Funders 0

None

BibTeX

@article{Gandhi_2012, title={Mechanism of Oxidative Stress in Neurodegeneration}, volume={2012}, ISSN={1942-0994}, url={http://dx.doi.org/10.1155/2012/428010}, DOI={10.1155/2012/428010}, journal={Oxidative Medicine and Cellular Longevity}, publisher={Hindawi Limited}, author={Gandhi, Sonia and Abramov, Andrey Y.}, year={2012}, pages={1–11} }

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