DOI: 10.1152/physrev.1998.78.4.1193. Current Understanding of the Molecular Actions of Vitamin D

Current Understanding of the Molecular Actions of Vitamin D

10.1152/physrev.1998.78.4.1193

Crossref journal-article

American Physiological Society

Physiological Reviews (24)

Abstract

Jones, Glenville, Stephen A. Strugnell, and Hector F. DeLuca. Current Understanding of the Molecular Actions of Vitamin D. Physiol. Rev. 78: 1193–1231, 1998. — The important reactions that occur to the vitamin D molecule and the important reactions involved in the expression of the final active form of vitamin D are reviewed in a critical manner. After an overview of the metabolism of vitamin D to its active form and to its metabolic degradation products, the molecular understanding of the 1α-hydroxylation reaction and the 24-hydroxylation reaction of the vitamin D hormone is presented. Furthermore, the role of vitamin D in maintenance of serum calcium is reviewed at the physiological level and at the molecular level whenever possible. Of particular importance is the regulation of the parathyroid gland by the vitamin D hormone. A third section describes the known molecular events involved in the action of 1α,25-dihydroxyvitamin D3on its target cells. This includes reviewing what is now known concerning the overall mechanism of transcriptional regulation by vitamin D. It describes the vitamin D receptors that have been cloned and identified and describes the coactivators and retinoid X receptors required for the function of vitamin D in its genomic actions. The presence of receptor in previously uncharted target organs of vitamin D action has led to a study of the possible function of vitamin D in these organs. A good example of a new function described for 1α,25-dihydroxyvitamin D3is that found in the parathyroid gland. This is also true for the role of vitamin D hormone in skin, the immune system, a possible role in the pancreas, i.e., in the islet cells, and a possible role in female reproduction. This review also raises the intriguing question of whether vitamin D plays an important role in embryonic development, since vitamin D deficiency does not prohibit development, nor does vitamin D receptor knockout. The final section reviews some interesting analogs of the vitamin D hormone and their possible uses. The review ends with possible ideas with regard to future directions of vitamin D drug design.

Bibliography

JONES, G., STRUGNELL, S. A., & DeLUCA, H. F. (1998). Current Understanding of the Molecular Actions of Vitamin D. Physiological Reviews, 78(4), 1193â1231.

Authors 3

GLENVILLE JONES (first)
STEPHEN A. STRUGNELL (additional)
HECTOR F. DeLUCA (additional)

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Dates

Type	When
Created	7 years, 8 months ago (Dec. 24, 2017, 3:24 p.m.)
Deposited	1 year, 2 months ago (June 29, 2024, 10:36 p.m.)
Indexed	2 days, 23 hours ago (Sept. 2, 2025, 6:51 a.m.)
Issued	26 years, 11 months ago (Oct. 1, 1998)
Published	26 years, 11 months ago (Oct. 1, 1998)
Published Print	26 years, 11 months ago (Oct. 1, 1998)

Funders 0

None

BibTeX

@article{JONES_1998, title={Current Understanding of the Molecular Actions of Vitamin D}, volume={78}, ISSN={1522-1210}, url={http://dx.doi.org/10.1152/physrev.1998.78.4.1193}, DOI={10.1152/physrev.1998.78.4.1193}, number={4}, journal={Physiological Reviews}, publisher={American Physiological Society}, author={JONES, GLENVILLE and STRUGNELL, STEPHEN A. and DeLUCA, HECTOR F.}, year={1998}, month=oct, pages={1193–1231} }

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  "abstract": "<jats:p>Jones, Glenville, Stephen A. Strugnell, and Hector F. DeLuca. Current Understanding of the Molecular Actions of Vitamin D. Physiol. Rev. 78: 1193\u20131231, 1998. \u2014 The important reactions that occur to the vitamin D molecule and the important reactions involved in the expression of the final active form of vitamin D are reviewed in a critical manner. After an overview of the metabolism of vitamin D to its active form and to its metabolic degradation products, the molecular understanding of the 1\u03b1-hydroxylation reaction and the 24-hydroxylation reaction of the vitamin D hormone is presented. Furthermore, the role of vitamin D in maintenance of serum calcium is reviewed at the physiological level and at the molecular level whenever possible. Of particular importance is the regulation of the parathyroid gland by the vitamin D hormone. A third section describes the known molecular events involved in the action of 1\u03b1,25-dihydroxyvitamin D<jats:sub>3</jats:sub>on its target cells. This includes reviewing what is now known concerning the overall mechanism of transcriptional regulation by vitamin D. It describes the vitamin D receptors that have been cloned and identified and describes the coactivators and retinoid X receptors required for the function of vitamin D in its genomic actions. The presence of receptor in previously uncharted target organs of vitamin D action has led to a study of the possible function of vitamin D in these organs. A good example of a new function described for 1\u03b1,25-dihydroxyvitamin D<jats:sub>3</jats:sub>is that found in the parathyroid gland. This is also true for the role of vitamin D hormone in skin, the immune system, a possible role in the pancreas, i.e., in the islet cells, and a possible role in female reproduction. This review also raises the intriguing question of whether vitamin D plays an important role in embryonic development, since vitamin D deficiency does not prohibit development, nor does vitamin D receptor knockout. The final section reviews some interesting analogs of the vitamin D hormone and their possible uses. The review ends with possible ideas with regard to future directions of vitamin D drug design.</jats:p>",
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