DOI: 10.1152/physrev.00035.2006. Inositol Trisphosphate Receptor Ca<sup>2+</sup>Release Channels

Inositol Trisphosphate Receptor Ca2+Release Channels
10.1152/physrev.00035.2006
Crossref journal-article
American Physiological Society
Physiological Reviews (24)
Abstract
The inositol 1,4,5-trisphosphate (InsP3) receptors (InsP3Rs) are a family of Ca2+release channels localized predominately in the endoplasmic reticulum of all cell types. They function to release Ca2+into the cytoplasm in response to InsP3produced by diverse stimuli, generating complex local and global Ca2+signals that regulate numerous cell physiological processes ranging from gene transcription to secretion to learning and memory. The InsP3R is a calcium-selective cation channel whose gating is regulated not only by InsP3, but by other ligands as well, in particular cytoplasmic Ca2+. Over the last decade, detailed quantitative studies of InsP3R channel function and its regulation by ligands and interacting proteins have provided new insights into a remarkable richness of channel regulation and of the structural aspects that underlie signal transduction and permeation. Here, we focus on these developments and review and synthesize the literature regarding the structure and single-channel properties of the InsP3R.
Bibliography
Foskett, J. K., White, C., Cheung, K.-H., & Mak, D.-O. D. (2007). Inositol Trisphosphate Receptor Ca2+Release Channels. Physiological Reviews, 87(2), 593â658.
Authors 4
J. Kevin Foskett (first)
Carl White (additional)
King-Ho Cheung (additional)
Don-On Daniel Mak (additional)
References 551 Referenced 1,025
Dates
Type	When
Created	18 years, 4 months ago (April 11, 2007, 2:52 p.m.)
Deposited	2 years, 3 months ago (May 11, 2023, 8:07 a.m.)
Indexed	3 hours ago (Sept. 3, 2025, 7:16 a.m.)
Issued	18 years, 5 months ago (April 1, 2007)
Published	18 years, 5 months ago (April 1, 2007)
Published Print	18 years, 5 months ago (April 1, 2007)
Funders 0
None
BibTeX
@article{Foskett_2007, title={Inositol Trisphosphate Receptor Ca2+Release Channels}, volume={87}, ISSN={1522-1210}, url={http://dx.doi.org/10.1152/physrev.00035.2006}, DOI={10.1152/physrev.00035.2006}, number={2}, journal={Physiological Reviews}, publisher={American Physiological Society}, author={Foskett, J. Kevin and White, Carl and Cheung, King-Ho and Mak, Don-On Daniel}, year={2007}, month=apr, pages={593–658} }
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