DOI: 10.1152/jn.2001.86.1.321. Chemical Induction of mGluR5- and Protein Synthesis–Dependent Long-Term Depression in Hippocampal Area CA1

Chemical Induction of mGluR5- and Protein Synthesis–Dependent Long-Term Depression in Hippocampal Area CA1

10.1152/jn.2001.86.1.321

Crossref journal-article

American Physiological Society

Journal of Neurophysiology (24)

Abstract

Recent work has demonstrated that specific patterns of synaptic stimulation can induce long-term depression (LTD) in area CA1 that depends on activation of metabotropic glutamate receptors (mGluRs) and rapid protein synthesis. Here we show that the same form of synaptic modification can be induced by brief application of the selective mGluR agonist (RS)-3,5-dihydroxyphenylglycine (DHPG). DHPG-LTD 1) is a saturable form of synaptic plasticity, 2) requires mGluR5, 3) is mechanistically distinct from N-methyl-d-aspartate receptor (NMDAR)–dependent LTD, and 4) shares a common expression mechanism with protein synthesis–dependent LTD evoked using synaptic stimulation. DHPG-LTD should be useful for biochemical analysis of mGluR5- and protein synthesis–dependent synaptic modification.

Bibliography

Huber, K. M., Roder, J. C., & Bear, M. F. (2001). Chemical Induction of mGluR5- and Protein SynthesisâDependent Long-Term Depression in Hippocampal Area CA1. Journal of Neurophysiology, 86(1), 321â325.

Authors 3

Kimberly M. Huber (first)
John C. Roder (additional)
Mark F. Bear (additional)

References 15 Referenced 330

Dates

Type	When
Created	7 years, 8 months ago (Dec. 21, 2017, 12:54 a.m.)
Deposited	5 years, 11 months ago (Sept. 8, 2019, 8:20 p.m.)
Indexed	3 months ago (June 5, 2025, 12:51 a.m.)
Issued	24 years, 2 months ago (July 1, 2001)
Published	24 years, 2 months ago (July 1, 2001)
Published Print	24 years, 2 months ago (July 1, 2001)

Funders 0

None

BibTeX

@article{Huber_2001, title={Chemical Induction of mGluR5- and Protein Synthesis–Dependent Long-Term Depression in Hippocampal Area CA1}, volume={86}, ISSN={1522-1598}, url={http://dx.doi.org/10.1152/jn.2001.86.1.321}, DOI={10.1152/jn.2001.86.1.321}, number={1}, journal={Journal of Neurophysiology}, publisher={American Physiological Society}, author={Huber, Kimberly M. and Roder, John C. and Bear, Mark F.}, year={2001}, month=jul, pages={321–325} }

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