DOI: 10.1152/jn.2001.85.1.425. GABA, Not Glutamate, a Primary Transmitter Driving Action Potentials in Developing Hypothalamic Neurons

GABA, Not Glutamate, a Primary Transmitter Driving Action Potentials in Developing Hypothalamic Neurons

10.1152/jn.2001.85.1.425

Crossref journal-article

American Physiological Society

Journal of Neurophysiology (24)

Abstract

Neuronal activity is critical for many aspects of brain development. It has often been assumed that the primary excitatory transmitter driving this activity is glutamate. In contrast, we report that during early development, synaptic release of GABA, the primary inhibitory neurotransmitter in the mature brain, is not only excitatory but in addition plays a more robust role than glutamate in generating spike activity in mouse hypothalamic neurons. Based on gramicidin perforated whole cell and extracellular recording, which leave intracellular Cl−unperturbed in brain slices and cultures, the GABAAreceptor antagonist bicuculline induced a dramatic decrease in spike frequency (83% decrease) in developing neurons, three times greater than that generated by glutamate receptor antagonists 2-amino-5-phosphono-pentanoic acid and 6-cyano-7-nitroquinoxalene-2,3-dione. Thus a number of factors related to spike-dependent stabilization of neuronal connections, including Hebbian mechanisms, that are generally applied to glutamate transmission may also participate in stabilization of GABA circuits.

Bibliography

Gao, X.-B., & Van Den Pol, A. N. (2001). GABA, Not Glutamate, a Primary Transmitter Driving Action Potentials in Developing Hypothalamic Neurons. Journal of Neurophysiology, 85(1), 425â434.

Authors 2

Xiao-Bing Gao (first)
Anthony N. Van Den Pol (additional)

References 51 Referenced 77

Dates

Type	When
Created	7 years, 8 months ago (Dec. 21, 2017, 5:42 a.m.)
Deposited	3 years ago (Aug. 10, 2022, 7:48 p.m.)
Indexed	1 year, 1 month ago (July 22, 2024, 2:37 a.m.)
Issued	24 years, 7 months ago (Jan. 1, 2001)
Published	24 years, 7 months ago (Jan. 1, 2001)
Published Print	24 years, 7 months ago (Jan. 1, 2001)

Funders 0

None

BibTeX

@article{Gao_2001, title={GABA, Not Glutamate, a Primary Transmitter Driving Action Potentials in Developing Hypothalamic Neurons}, volume={85}, ISSN={1522-1598}, url={http://dx.doi.org/10.1152/jn.2001.85.1.425}, DOI={10.1152/jn.2001.85.1.425}, number={1}, journal={Journal of Neurophysiology}, publisher={American Physiological Society}, author={Gao, Xiao-Bing and Van Den Pol, Anthony N.}, year={2001}, month=jan, pages={425–434} }

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