DOI: 10.1152/jn.2000.84.3.1194. Tonic and Synaptically Evoked Presynaptic Inhibition of Sensory Input to the Rat Olfactory Bulb Via GABA<sub>B</sub>Heteroreceptors

Tonic and Synaptically Evoked Presynaptic Inhibition of Sensory Input to the Rat Olfactory Bulb Via GABABHeteroreceptors

10.1152/jn.2000.84.3.1194

Crossref journal-article

American Physiological Society

Journal of Neurophysiology (24)

Abstract

Olfactory receptor neurons of the nasal epithelium send their axons, via the olfactory nerve (ON), to the glomeruli of the olfactory bulb (OB), where the axon terminals form glutamatergic synapses with the apical dendrites of mitral and tufted cells, the output cells of the OB, and with juxtaglomerular (JG) interneurons. Many JG cells are GABAergic. Here we show that, despite the absence of conventional synapses, GABA released from JG cells activates GABABreceptors on ON terminals and inhibits glutamate release both tonically and in response to ON stimulation. Field potential recordings and current-source density analysis, as well as intracellular and whole cell recording techniques were used in rat OB slices. Baclofen (2–5 μM), a GABABagonist, completely suppressed ON-evoked synaptic responses of both mitral/tufted cells and JG cells, with no evidence for postsynaptic effects. Baclofen (0.5–1 μM) also reversed paired-pulse depression (PPD) of mitral/tufted cell responses to paired-pulse facilitation (PPF), and reduced depression of JG cell excitatory postsynaptic currents (EPSCs) during repetitive ON stimulation. These results suggest that baclofen reduced the probability of glutamate release from ON terminals. The GABABantagonists CGP35348 or CGP55845A increased mitral/tufted cell responses evoked by single-pulse ON stimulation, suggesting that glutamate release from ON terminals is tonically suppressed via GABABreceptors. The same antagonists reduced PPD of ON-evoked mitral/tufted cell responses at interstimulus intervals 50–400 ms. This finding suggests that a single ON impulse evokes sufficient GABA release, presumably from JG cells, to activate GABABreceptors on ON terminals. Thus GABABheteroreceptors on ON terminals are activated by ambient levels of extrasynaptic GABA, and by ON input to the OB. The time course of ON-evoked, GABABpresynaptic inhibition suggests that neurotransmission to M/T cells and JG cells will be significantly suppressed when ON impulses arrive in glomeruli at 2.5–20 Hz. GABABreceptor–mediated presynaptic inhibition of sensory input to the OB may play an important role in shaping the activation pattern of the OB glomeruli during olfactory coding.

Bibliography

Aroniadou-Anderjaska, V., Zhou, F.-M., Priest, C. A., Ennis, M., & Shipley, M. T. (2000). Tonic and Synaptically Evoked Presynaptic Inhibition of Sensory Input to the Rat Olfactory Bulb Via GABABHeteroreceptors. Journal of Neurophysiology, 84(3), 1194â1203.

Authors 5

Vassiliki Aroniadou-Anderjaska (first)
Fu-Ming Zhou (additional)
Catherine A. Priest (additional)
Matthew Ennis (additional)
Michael T. Shipley (additional)

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Dates

Type	When
Created	7 years, 8 months ago (Dec. 21, 2017, 9 a.m.)
Deposited	3 years ago (Aug. 10, 2022, 8:05 p.m.)
Indexed	3 weeks, 1 day ago (Aug. 7, 2025, 5:21 p.m.)
Issued	24 years, 11 months ago (Sept. 1, 2000)
Published	24 years, 11 months ago (Sept. 1, 2000)
Published Print	24 years, 11 months ago (Sept. 1, 2000)

Funders 0

None

BibTeX

@article{Aroniadou_Anderjaska_2000, title={Tonic and Synaptically Evoked Presynaptic Inhibition of Sensory Input to the Rat Olfactory Bulb Via GABABHeteroreceptors}, volume={84}, ISSN={1522-1598}, url={http://dx.doi.org/10.1152/jn.2000.84.3.1194}, DOI={10.1152/jn.2000.84.3.1194}, number={3}, journal={Journal of Neurophysiology}, publisher={American Physiological Society}, author={Aroniadou-Anderjaska, Vassiliki and Zhou, Fu-Ming and Priest, Catherine A. and Ennis, Matthew and Shipley, Michael T.}, year={2000}, month=sep, pages={1194–1203} }

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