DOI: 10.1152/jn.1998.80.6.3383. Brain-Derived Neurotrophic Factor (BDNF) Modulates Inhibitory, But Not Excitatory, Transmission in the CA1 Region of the Hippocampus

Brain-Derived Neurotrophic Factor (BDNF) Modulates Inhibitory, But Not Excitatory, Transmission in the CA1 Region of the Hippocampus

10.1152/jn.1998.80.6.3383

Crossref journal-article

American Physiological Society

Journal of Neurophysiology (24)

Abstract

Frerking, M., R. C. Malenka, and R. A. Nicoll. Brain-derived neurotrophic factor (BDNF) modulates inhibitory, but not excitatory, transmission in the CA1 region of the hippocampus. J. Neurophysiol. 80: 3383–3386, 1998. Brain-derived neurotrophic factor (BDNF) has been reported to have rapid effects on synaptic transmission in the hippocampus. We report here that bath application of BDNF causes a small but significant decrease in stimulus-evoked inhibitory postsynaptic currents (IPSCs) on CA1 pyramidal cells, which is prevented by the tyrosine kinase inhibitor lavendustin A. BDNF causes a decrease in the 1/CV2 of the IPSC, and also reduces paired-pulse depression of the IPSC, suggesting a presynaptic site of action. In contrast, BDNF did not have a detectable effect on field excitatory postsynaptic potentials measured in stratum radiatum. We conclude that BDNF has a selective depressant action on inhibitory transmission in the hippocampus, due at least in part to a presynaptic mechanism.

Bibliography

Frerking, M., Malenka, R. C., & Nicoll, R. A. (1998). Brain-Derived Neurotrophic Factor (BDNF) Modulates Inhibitory, But Not Excitatory, Transmission in the CA1 Region of the Hippocampus. Journal of Neurophysiology, 80(6), 3383â3386.

Authors 3

M. Frerking (first)
R. C. Malenka (additional)
R. A. Nicoll (additional)

References 17 Referenced 169

Dates

Type	When
Created	7 years, 8 months ago (Dec. 25, 2017, midnight)
Deposited	5 years, 11 months ago (Sept. 9, 2019, 1:23 a.m.)
Indexed	4 months, 1 week ago (April 22, 2025, 4:12 a.m.)
Issued	26 years, 9 months ago (Dec. 1, 1998)
Published	26 years, 9 months ago (Dec. 1, 1998)
Published Print	26 years, 9 months ago (Dec. 1, 1998)

Funders 0

None

BibTeX

@article{Frerking_1998, title={Brain-Derived Neurotrophic Factor (BDNF) Modulates Inhibitory, But Not Excitatory, Transmission in the CA1 Region of the Hippocampus}, volume={80}, ISSN={1522-1598}, url={http://dx.doi.org/10.1152/jn.1998.80.6.3383}, DOI={10.1152/jn.1998.80.6.3383}, number={6}, journal={Journal of Neurophysiology}, publisher={American Physiological Society}, author={Frerking, M. and Malenka, R. C. and Nicoll, R. A.}, year={1998}, month=dec, pages={3383–3386} }

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