DOI: 10.1152/jn.1998.80.6.3321. Functional Reorganization of the Rat Motor Cortex Following Motor Skill Learning

Functional Reorganization of the Rat Motor Cortex Following Motor Skill Learning

10.1152/jn.1998.80.6.3321

Crossref journal-article

American Physiological Society

Journal of Neurophysiology (24)

Abstract

Kleim, Jeffrey A., Scott Barbay, and Randolph J. Nudo. Functional reorganization of the rat motor cortex following motor skill learning. J. Neurophysiol. 80: 3321–3325, 1998. Adult rats were allocated to either a skilled or unskilled reaching condition (SRC and URC, respectively). SRC animals were trained for 10 days on a skilled reaching task while URC animals were trained on a simple bar pressing task. After training, microelectrode stimulation was used to derive high resolution maps of the forelimb and hindlimb representations within the motor cortex. In comparison with URC animals, SRC animals exhibited a significant increase in mean area of the wrist and digit representations but a decrease in elbow/shoulder representation within the caudal forelimb area. No between-group differences in areal representation were found in either the hindlimb or rostral forelimb areas. These results demonstrate that motor skill learning is associated with a reorganization of movement representations within the rodent motor cortex.

Bibliography

Kleim, J. A., Barbay, S., & Nudo, R. J. (1998). Functional Reorganization of the Rat Motor Cortex Following Motor Skill Learning. Journal of Neurophysiology, 80(6), 3321â3325.

Authors 3

Jeffrey A. Kleim (first)
Scott Barbay (additional)
Randolph J. Nudo (additional)

References 25 Referenced 629

10.1016/0166-4328(90)90122-U
10.1016/0006-8993(72)90665-8
10.1016/0006-8993(85)90141-6
10.1007/BF00229319
{'key': 'B5', 'first-page': '227', 'volume': '23', 'author': 'Friedman D.', 'year': '1997', 'journal-title': 'Soc. Neursoci. Abstr.'} / Soc. Neursoci. Abstr. by Friedman D. (1997)
10.1016/S0163-1047(85)90310-3
10.1523/JNEUROSCI.17-23-09220.1997
10.1126/science.2000496
10.1097/00001756-199610020-00019
10.1523/JNEUROSCI.16-14-04529.1996
10.1006/nlme.1998.3827
10.1126/science.3142040
10.1016/0165-0173(86)90011-1
10.1016/0006-8993(82)90617-5
10.3109/08990229009144720
10.1523/JNEUROSCI.16-02-00785.1996
10.1006/smns.1997.0102
10.1016/0006-8993(81)90721-6
10.3109/08990229309028837
10.1016/0006-8993(86)90684-0
10.1098/rstb.1990.0161
10.1016/0166-4328(90)90053-H
10.1016/0166-4328(93)90022-I
10.1016/0028-3932(89)90090-0
10.1016/0006-8993(91)90688-R

Dates

Type	When
Created	7 years, 8 months ago (Dec. 24, 2017, 7 p.m.)
Deposited	5 years, 11 months ago (Sept. 8, 2019, 9:23 p.m.)
Indexed	5 days, 1 hour ago (Aug. 29, 2025, 5:46 a.m.)
Issued	26 years, 9 months ago (Dec. 1, 1998)
Published	26 years, 9 months ago (Dec. 1, 1998)
Published Print	26 years, 9 months ago (Dec. 1, 1998)

Funders 0

None

BibTeX

@article{Kleim_1998, title={Functional Reorganization of the Rat Motor Cortex Following Motor Skill Learning}, volume={80}, ISSN={1522-1598}, url={http://dx.doi.org/10.1152/jn.1998.80.6.3321}, DOI={10.1152/jn.1998.80.6.3321}, number={6}, journal={Journal of Neurophysiology}, publisher={American Physiological Society}, author={Kleim, Jeffrey A. and Barbay, Scott and Nudo, Randolph J.}, year={1998}, month=dec, pages={3321–3325} }

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