DOI: 10.1152/jn.1998.79.1.483. Dynamic Properties of Corticothalamic Neurons and Local Cortical Interneurons Generating Fast Rhythmic (30

Dynamic Properties of Corticothalamic Neurons and Local Cortical Interneurons Generating Fast Rhythmic (30–40 Hz) Spike Bursts

10.1152/jn.1998.79.1.483

Crossref journal-article

American Physiological Society

Journal of Neurophysiology (24)

Abstract

Steriade, Mircea, Igor Timofeev, Niklaus Dürmüller, and François Grenier. Dynamic properties of corticothalamic neurons and local cortical interneurons generating fast rhythmic (30–40 Hz) spike-bursts. J. Neurophysiol. 79: 483–490, 1998. Fast spontaneous oscillations (mainly 30–40 Hz) characterize cortical and thalamic neuronal networks during behavioral states of increased vigilance and depend on cell depolarization under the influence of ascending activating systems. We investigated, by means of intracellular recording and staining in vivo, the properties of fast-oscillating cortical neurons from cat's motor and association areas, some projecting to the thalamus, others with locally arborizing axons. At a given level of depolarization, 28% of our neuronal sample discharged high-frequency spike bursts (300–600 Hz) that recurred rhythmically between 20 and 50 Hz. Such fast rhythmic bursting neurons have been found in both superficial and deep cortical layers. Slight changes in membrane potential as well as synaptic activity in thalamocortical networks dramatically altered the discharge patterns, from single spikes to rhythmic spike-bursts, and eventually to fast tonic firing without frequency adaptation. Thus our data challenge the conventional idea that sharply defined, invariant features and distinct locations in certain cortical layers characterize some neocortical cell-classes. We demonstrate that the distinctions between intrinsic electrophysiological properties of neocortical neurons are much more labile than conventionally thought. The present results, which indicate that corticothalamic neurons discharge fast rhythmic spike bursts mainly at 30–40 Hz, suggest that this activity results in integrated fast oscillations within corticothalamic networks.

Bibliography

Steriade, M., Timofeev, I., DÃ¼rmÃ¼ller, N., & Grenier, F. (1998). Dynamic Properties of Corticothalamic Neurons and Local Cortical Interneurons Generating Fast Rhythmic (30â40 Hz) Spike Bursts. Journal of Neurophysiology, 79(1), 483â490.

Authors 4

Mircea Steriade (first)
Igor Timofeev (additional)
Niklaus Dürmüller (additional)
François Grenier (additional)

References 41 Referenced 197

Dates

Type	When
Created	7 years, 8 months ago (Dec. 25, 2017, 2:16 a.m.)
Deposited	5 years, 11 months ago (Sept. 9, 2019, 1:23 a.m.)
Indexed	1 month, 3 weeks ago (July 14, 2025, 11:49 p.m.)
Issued	27 years, 8 months ago (Jan. 1, 1998)
Published	27 years, 8 months ago (Jan. 1, 1998)
Published Print	27 years, 8 months ago (Jan. 1, 1998)

Funders 0

None

BibTeX

@article{Steriade_1998, title={Dynamic Properties of Corticothalamic Neurons and Local Cortical Interneurons Generating Fast Rhythmic (30–40 Hz) Spike Bursts}, volume={79}, ISSN={1522-1598}, url={http://dx.doi.org/10.1152/jn.1998.79.1.483}, DOI={10.1152/jn.1998.79.1.483}, number={1}, journal={Journal of Neurophysiology}, publisher={American Physiological Society}, author={Steriade, Mircea and Timofeev, Igor and Dürmüller, Niklaus and Grenier, François}, year={1998}, month=jan, pages={483–490} }

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