DOI: 10.1152/japplphysiol.00527.2002. Local particle deposition patterns may play a key role in the development of lung cancer

Local particle deposition patterns may play a key role in the development of lung cancer

10.1152/japplphysiol.00527.2002

Crossref journal-article

American Physiological Society

Journal of Applied Physiology (24)

Abstract

The apparent discrepancy between the reported preferential occurrence of bronchial carcinomas in central bronchial airways and current dose estimates for inhaled particles suggests that experimentally observed local accumulations of particles within bronchial airway bifurcations may play a crucial role in lung cancer induction. Here, we computed three-dimensional particle deposition patterns in lobar-segmental airway bifurcations and quantified the resulting inhomogeneous deposition patterns in terms of deposition enhancement factors, which are defined as the ratio of local to average deposition densities. Our results revealed that a small fraction of epithelial cells located at carinal ridges can receive massive doses that may be even a few hundred times higher than the average dose for the whole airway. This lends further credence to the hypothesis that the apparent site selectivity of neoplastic lesions may indeed be caused by the enhanced deposition of toxic particulate matter at bronchial airway bifurcations.

Authors 3

Imre Balásházy (first)
Werner Hofmann (additional)
Thomas Heistracher (additional)

References 32 Referenced 175

10.1056/NEJM196108102650601
10.1016/0021-8502(94)00106-9
10.1097/00004032-200002000-00004
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{'key': 'B5', 'first-page': '173', 'volume': '20', 'author': 'Bryson CC', 'year': '1951', 'journal-title': 'Q J Med'} / Q J Med by Bryson CC (1951)
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10.1002/1097-0142(1955)8:4<673::AID-CNCR2820080404>3.0.CO;2-G
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{'key': 'B28', 'first-page': '225', 'volume': '15', 'author': 'Martonen TB', 'year': '1986', 'journal-title': 'Rad Prot Dosim'} / Rad Prot Dosim by Martonen TB (1986)
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{'key': 'B33', 'first-page': '47', 'volume': '26', 'author': 'Schlesinger BR', 'year': '1982', 'journal-title': 'Am Occup Hyg'} / Am Occup Hyg by Schlesinger BR (1982)
10.1016/0013-9351(78)90123-8
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10.1016/S0021-8502(01)00170-7

Dates

Type	When
Created	10 years, 5 months ago (March 3, 2015, 3:44 p.m.)
Deposited	5 years ago (Aug. 30, 2020, 9:38 a.m.)
Indexed	3 days, 16 hours ago (Aug. 27, 2025, 11:56 a.m.)
Issued	22 years, 3 months ago (May 1, 2003)
Published	22 years, 3 months ago (May 1, 2003)
Published Print	22 years, 3 months ago (May 1, 2003)

Funders 0

None

BibTeX

@article{Bal_sh_zy_2003, title={Local particle deposition patterns may play a key role in the development of lung cancer}, volume={94}, ISSN={1522-1601}, url={http://dx.doi.org/10.1152/japplphysiol.00527.2002}, DOI={10.1152/japplphysiol.00527.2002}, number={5}, journal={Journal of Applied Physiology}, publisher={American Physiological Society}, author={Balásházy, Imre and Hofmann, Werner and Heistracher, Thomas}, year={2003}, month=may, pages={1719–1725} }

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