DOI: 10.1152/jappl.1999.87.6.2043. Analysis of intrapulmonary O<sub>2</sub>concentration by MR imaging of inhaled hyperpolarized helium-3

Analysis of intrapulmonary O2concentration by MR imaging of inhaled hyperpolarized helium-3

10.1152/jappl.1999.87.6.2043

Crossref journal-article

American Physiological Society

Journal of Applied Physiology (24)

Abstract

Inhalation of hyperpolarized 3He allows magnetic resonance imaging (MRI) of ventilated airspaces.3He hyperpolarization decays more rapidly when interacting with paramagnetic O2. We describe a method for in vivo determination of intrapulmonary O2 concentrations ([O2]) based on MRI analysis of the fate of measured amounts of inhaled hyperpolarized3He in imaged regions of the lung. Anesthetized pigs underwent controlled normoventilation in a 1.5-T MRI unit. The inspired O2 fraction was varied to achieve different end-tidal [O2] fractions ([Formula: see text]). With the use of a specifically designed applicator,3He (100 ml, 35–45% polarized) was administered at a predefined time within single tidal volumes. During subsequent inspiratory apnea, serial two-dimensional images of airways and lungs were acquired. At least once in each animal studied, the radio-frequency excitation used for imaging was doubled at constant[Formula: see text]. Signal intensity measurements in regions of interest of the animals' lungs (volume range, 54–294 cm3), taken at two different radio-frequency excitations, permitted calculation of [O2] in these regions of interest. The [O2] fractions in the regions of interest correlated closely with[Formula: see text]( R = 0.879; P < 0.0001). O2-sensitive3He-MRI may allow noninvasive study of regional distribution of ventilation and alveolar[Formula: see text] in the lung.

Bibliography

Eberle, B., Weiler, N., Markstaller, K., Kauczor, H.-U., Deninger, A., Ebert, M., Grossmann, T., Heil, W., Lauer, L. O., Roberts, T. P. L., Schreiber, W. G., Surkau, R., Dick, W. F., Otten, E. W., & Thelen, M. (1999). Analysis of intrapulmonary O2concentration by MR imaging of inhaled hyperpolarized helium-3. Journal of Applied Physiology, 87(6), 2043â2052.

Authors 15

B. Eberle (first)
N. Weiler (additional)
K. Markstaller (additional)
H.-U. Kauczor (additional)
A. Deninger (additional)
M. Ebert (additional)
T. Grossmann (additional)
W. Heil (additional)
L. O. Lauer (additional)
T. P. L. Roberts (additional)
W. G. Schreiber (additional)
R. Surkau (additional)
W. F. Dick (additional)
E. W. Otten (additional)
M. Thelen (additional)

References 20 Referenced 91

10.1038/370199a0
10.1002/mrm.1910360204
10.1148/radiology.199.3.8638019
10.1103/PhysRevLett.5.373
10.1103/PhysRev.132.2561
10.1016/S0140-6736(96)90940-X
10.1002/mrm.1910340618
10.1016/0375-9601(95)00243-V
10.1002/jmri.1880070314
10.1148/radiology.201.2.8888259
10.1148/radiology.200.2.8685356
10.1152/jappl.1997.82.3.933
10.1002/mrm.1910330219
10.1152/ajplegacy.1946.147.1.191 / Am. J. Physiol. by Riley R. L. (1946)
{'key': 'B18', 'first-page': '379', 'volume': '121', 'author': 'Robertson H. T.', 'year': '1998', 'journal-title': 'Complexity in Structure and Function of the Lung'} / Complexity in Structure and Function of the Lung by Robertson H. T. (1998)
{'key': 'B19', 'first-page': '4', 'volume': '26', 'author': 'Robinson N. E.', 'year': '1982', 'journal-title': 'Adv. Vet. Sci. Comp. Med.'} / Adv. Vet. Sci. Comp. Med. by Robinson N. E. (1982)
10.1103/PhysRevA.52.862
10.3109/01902149509031767
10.1016/S0168-9002(96)00923-0
10.1152/jappl.1980.49.1.132

Dates

Type	When
Created	7 years, 8 months ago (Dec. 22, 2017, 11:43 a.m.)
Deposited	5 years, 11 months ago (Sept. 8, 2019, 2:35 p.m.)
Indexed	4 months ago (April 22, 2025, 4:12 a.m.)
Issued	25 years, 8 months ago (Dec. 1, 1999)
Published	25 years, 8 months ago (Dec. 1, 1999)
Published Print	25 years, 8 months ago (Dec. 1, 1999)

Funders 0

None

BibTeX

@article{Eberle_1999, title={Analysis of intrapulmonary O2concentration by MR imaging of inhaled hyperpolarized helium-3}, volume={87}, ISSN={1522-1601}, url={http://dx.doi.org/10.1152/jappl.1999.87.6.2043}, DOI={10.1152/jappl.1999.87.6.2043}, number={6}, journal={Journal of Applied Physiology}, publisher={American Physiological Society}, author={Eberle, B. and Weiler, N. and Markstaller, K. and Kauczor, H.-U. and Deninger, A. and Ebert, M. and Grossmann, T. and Heil, W. and Lauer, L. O. and Roberts, T. P. L. and Schreiber, W. G. and Surkau, R. and Dick, W. F. and Otten, E. W. and Thelen, M.}, year={1999}, month=dec, pages={2043–2052} }

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  "abstract": "<jats:p> Inhalation of hyperpolarized <jats:sup>3</jats:sup>He allows magnetic resonance imaging (MRI) of ventilated airspaces.<jats:sup>3</jats:sup>He hyperpolarization decays more rapidly when interacting with paramagnetic O<jats:sub>2</jats:sub>. We describe a method for in vivo determination of intrapulmonary O<jats:sub>2</jats:sub> concentrations ([O<jats:sub>2</jats:sub>]) based on MRI analysis of the fate of measured amounts of inhaled hyperpolarized<jats:sup>3</jats:sup>He in imaged regions of the lung. Anesthetized pigs underwent controlled normoventilation in a 1.5-T MRI unit. The inspired O<jats:sub>2</jats:sub> fraction was varied to achieve different end-tidal [O<jats:sub>2</jats:sub>] fractions ([Formula: see text]). With the use of a specifically designed applicator,<jats:sup>3</jats:sup>He (100 ml, 35\u201345% polarized) was administered at a predefined time within single tidal volumes. During subsequent inspiratory apnea, serial two-dimensional images of airways and lungs were acquired. At least once in each animal studied, the radio-frequency excitation used for imaging was doubled at constant[Formula: see text]. Signal intensity measurements in regions of interest of the animals' lungs (volume range, 54\u2013294 cm<jats:sup>3</jats:sup>), taken at two different radio-frequency excitations, permitted calculation of [O<jats:sub>2</jats:sub>] in these regions of interest. The [O<jats:sub>2</jats:sub>] fractions in the regions of interest correlated closely with[Formula: see text]( R = 0.879; P &lt; 0.0001). O<jats:sub>2</jats:sub>-sensitive<jats:sup>3</jats:sup>He-MRI may allow noninvasive study of regional distribution of ventilation and alveolar[Formula: see text] in the lung. </jats:p>",
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