DOI: 10.1152/ajprenal.2001.281.3.f391. Trafficking and cell surface stability of ENaC

Trafficking and cell surface stability of ENaC

10.1152/ajprenal.2001.281.3.f391

Crossref journal-article

American Physiological Society

American Journal of Physiology-Renal Physiology (24)

Abstract

The epithelial Na+channel (ENaC) plays a key role in the regulation of Na+and water absorption in several epithelia, including those of the distal nephron, distal colon, and lung. Accordingly, mutations in ENaC leading to reduced or increased channel activity cause human diseases such as pseudohypoaldosteronism type I or Liddle's syndrome, respectively. The gain of ENaC function in Liddle's syndrome is associated with increased activity and stability of the channel at the plasma membrane. Thus understanding the regulation of channel processing and trafficking to and stability at the cell surface is of fundamental importance. This review describes some of the recent advances in our understanding of ENaC trafficking, including the role of glycosylation, ENaC solubility in nonionic detergent, targeting signal(s) and hormones. It also describes the regulation of ENaC stability at the cell surface and the roles of the ubiquitin ligase Nedd4 (and ubiquitination) and clathrin-mediated endocytosis in that regulation.

Bibliography

Rotin, D., Kanelis, V., & Schild, L. (2001). Trafficking and cell surface stability of ENaC. American Journal of Physiology-Renal Physiology, 281(3), F391âF399.

Authors 3

Daniela Rotin (first)
Voula Kanelis (additional)
Laurent Schild (additional)

References 90 Referenced 98

Dates

Type	When
Created	7 years, 8 months ago (Dec. 23, 2017, 9:12 a.m.)
Deposited	3 years ago (Aug. 10, 2022, 11:44 p.m.)
Indexed	1 week, 2 days ago (Aug. 26, 2025, 2:37 a.m.)
Issued	24 years ago (Sept. 1, 2001)
Published	24 years ago (Sept. 1, 2001)
Published Print	24 years ago (Sept. 1, 2001)

Funders 0

None

BibTeX

@article{Rotin_2001, title={Trafficking and cell surface stability of ENaC}, volume={281}, ISSN={1522-1466}, url={http://dx.doi.org/10.1152/ajprenal.2001.281.3.f391}, DOI={10.1152/ajprenal.2001.281.3.f391}, number={3}, journal={American Journal of Physiology-Renal Physiology}, publisher={American Physiological Society}, author={Rotin, Daniela and Kanelis, Voula and Schild, Laurent}, year={2001}, month=sep, pages={F391–F399} }

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