Developmental regulation of erythropoietin and erythropoiesis
10.1152/ajpregu.1997.273.6.r1829
Crossref journal-article
American Physiological Society
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (24)
Abstract

It is well established that erythropoiesis occurs first in the yolk sac, then in the liver, subsequently moving to the bone marrow and, in rodents, the spleen during development. The origin of the erythropoietic precursors and some factors suggested to be important for the changing location of erythropoiesis are discussed in this review. Until recently, the major site of erythropoietin (Epo) production in the fetus was thought to be the liver, but studies have shown now that the Epo gene is expressed strongly in the fetal kidney, even in the temporary mesonephros. The metanephric Epo mRNA is upregulated by anemia, downregulated by glucocorticoids, and contributes substantially to circulating hormone levels in hemorrhaged ovine fetuses. Other sites of Epo and Epo receptor production, likely to have important actions during development, are the placenta and the brain.

Bibliography

Moritz, K. M., Lim, G. B., & Wintour, E. M. (1997). Developmental regulation of erythropoietin and erythropoiesis. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 273(6), R1829–R1844.

Authors 3
  1. K. M. Moritz (first)
  2. Gaik Bee Lim (additional)
  3. E. M. Wintour (additional)
References 183 Referenced 51
  1. 10.1159/000203787
  2. 10.1016/0034-5687(94)90043-4
  3. 10.1016/S0021-9258(17)42195-8 / J. Biol. Chem. by Aird W. C. (1994)
  4. 10.1073/pnas.87.15.5978
  5. 10.1073/pnas.91.9.3974
  6. {'key': 'B6', 'first-page': '211', 'volume': '3', 'author': 'Aron D. C.', 'year': '1992', 'journal-title': 'Biofactors'} / Biofactors by Aron D. C. (1992)
  7. 10.1177/41.3.8429197
  8. 10.1128/MCB.14.10.6506
  9. 10.1016/0167-5699(90)90139-Z
  10. 10.1159/000143030
  11. 10.1136/adc.69.1_Spec_No.19
  12. 10.1113/expphysiol.1985.sp002899
  13. 10.1038/358499a0
  14. {'key': 'B14', 'first-page': '133', 'volume': '10', 'author': 'Billat C. L.', 'year': '1982', 'journal-title': 'Exp. Hematol.'} / Exp. Hematol. by Billat C. L. (1982)
  15. 10.1128/MCB.12.12.5373
  16. 10.1182/blood.V80.10.2503.2503 / Blood by Boyer S. H. (1992)
  17. {'issue': '13', 'key': 'B17', 'first-page': 'H487', 'volume': '244', 'author': 'Brace R. A.', 'year': '1983', 'journal-title': 'Am. J. Physiol.'} / Am. J. Physiol. by Brace R. A. (1983)
  18. 10.1152/physrev.1996.76.3.839
  19. 10.1677/joe.0.1460459
  20. 10.1074/jbc.271.38.23374
  21. {'key': 'B21', 'first-page': '528', 'volume': '7', 'author': 'Chang T.-J.', 'year': '1993', 'journal-title': 'Mol. Endocrinol.'} / Mol. Endocrinol. by Chang T.-J. (1993)
  22. 10.1182/blood.V68.4.892.892 / Blood by Clemons G. K. (1986)
  23. 10.1073/pnas.92.6.1817
  24. 10.1096/fasebj.10.7.8635693
  25. {'key': 'B25', 'first-page': '228', 'volume': '4', 'author': 'Conrad K. P.', 'year': '1997', 'journal-title': 'J. Soc. Gynecol. Invest.'} / J. Soc. Gynecol. Invest. by Conrad K. P. (1997)
  26. 10.1111/j.1471-0528.1983.tb08914.x
  27. 10.1146/annurev.me.32.020181.001043
  28. 10.1111/j.1365-2141.1995.tb03299.x
  29. 10.1073/pnas.90.10.4495
  30. {'issue': '34', 'key': 'B30', 'first-page': 'R399', 'volume': '265', 'author': 'Del Valle G. O.', 'year': '1993', 'journal-title': 'Am. J. Physiol.'} / Am. J. Physiol. by Del Valle G. O. (1993)
  31. 10.1021/bi00156a003
  32. 10.1073/pnas.92.9.3717
  33. 10.1093/oxfordjournals.bmb.a071188
  34. {'key': 'B34', 'first-page': '27', 'volume': '87', 'author': 'Doetschman T. C.', 'year': '1985', 'journal-title': 'J. Embryol. Exp. Morphol.'} / J. Embryol. Exp. Morphol. by Doetschman T. C. (1985)
  35. 10.1016/S0021-9258(19)77865-X / J. Biol. Chem. by Dube S. (1988)
  36. 10.1159/000187882
  37. 10.1007/BF01959395
  38. 10.1172/JCI114280
  39. 10.1182/blood.V74.1.49.49 / Blood by Emerson S. G. (1989)
  40. 10.1136/adc.68.3_Spec_No.291
  41. 10.1111/j.1365-2141.1980.tb03811.x
  42. 10.1679/aohc.52.407
  43. 10.1016/0092-8674(89)90940-9
  44. 10.1073/pnas.85.16.5976
  45. 10.1046/j.1537-2995.1995.351196110899.x
  46. 10.1016/0024-3205(90)90225-G
  47. 10.1042/bj3030507
  48. 10.1016/S0021-9258(20)80472-4 / J. Biol. Chem. by Fischer K.-D. (1996)
  49. 10.1046/j.1365-2141.1996.d01-1864.x
  50. 10.1182/blood.V77.11.2360.2360 / Blood by Forestier F. (1991)
  51. 10.1016/0303-7207(93)90113-X
  52. 10.1073/pnas.93.22.12355
  53. 10.1083/jcb.127.6.1743
  54. 10.1182/blood.V82.11.3321.3321 / Blood by Galson D. L. (1993)
  55. 10.1203/00006450-199012000-00003
  56. {'key': 'B57', 'first-page': '501', 'volume': '7', 'author': 'Glomski C. A.', 'year': '1992', 'journal-title': 'Histol. Histopathol.'} / Histol. Histopathol. by Glomski C. A. (1992)
  57. 10.1126/science.2849206
  58. {'issue': '37', 'key': 'B59', 'first-page': 'R1117', 'volume': '268', 'author': 'Gough S. R.', 'year': '1995', 'journal-title': 'Am. J. Physiol.'} / Am. J. Physiol. by Gough S. R. (1995)
  59. {'key': 'B60', 'first-page': '399', 'volume': '5', 'author': 'Gruber D. F.', 'year': '1977', 'journal-title': 'Exp. Hematol.'} / Exp. Hematol. by Gruber D. F. (1977)
  60. {'key': 'B61', 'first-page': '219', 'volume': '76', 'author': 'Halmesmaki E.', 'year': '1990', 'journal-title': 'Obstet. Gynecol.'} / Obstet. Gynecol. by Halmesmaki E. (1990)
  61. 10.1016/S0022-3476(05)82671-X
  62. 10.1182/blood.V87.6.2513.bloodjournal8762513 / Blood by Hamamura K. (1996)
  63. {'key': 'B64', 'first-page': '11', 'volume': '11', 'author': 'Hanicki Z.', 'year': '1990', 'journal-title': 'Contrib. Nephrol.'} / Contrib. Nephrol. by Hanicki Z. (1990)
  64. 10.1002/(SICI)1096-8652(199605)52:1<8::AID-AJH2>3.0.CO;2-Z
  65. 10.1016/S0021-9258(18)42572-0 / J. Biol. Chem. by Higuchi M. (1992)
  66. 10.1038/380171a0
  67. 10.1073/pnas.93.18.9493
  68. 10.1203/00006450-198811000-00013
  69. 10.1038/ki.1997.76
  70. 10.1016/0092-8674(92)90115-S
  71. 10.1016/S0021-9258(17)37073-4 / J. Biol. Chem. by Imagawa S. (1994)
  72. 10.1159/000203892
  73. 10.1038/313806a0
  74. 10.1038/179633a0
  75. {'key': 'B76', 'first-page': '895', 'volume': '127', 'author': 'Jacquot R.', 'year': '1976', 'journal-title': 'Ann. Immunol. (Inst. Pasteur)'} / Ann. Immunol. (Inst. Pasteur) by Jacquot R. (1976)
  76. 10.1152/physrev.1992.72.2.449
  77. {'key': 'B78', 'first-page': 'S3', 'volume': '72', 'author': 'Jelkmann W.', 'year': '1994', 'journal-title': 'Clin. Invest. Med.'} / Clin. Invest. Med. by Jelkmann W. (1994)
  78. 10.1074/jbc.271.28.16472
  79. {'key': 'B80', 'first-page': '1715', 'volume': '39', 'author': 'Juul S. E.', 'year': '1996', 'journal-title': 'Pediatr. Res.'} / Pediatr. Res. by Juul S. E. (1996)
  80. 10.1203/00006450-199604001-01324
  81. 10.1016/0006-8993(93)90850-M
  82. 10.1111/j.1432-1033.1992.tb17466.x
  83. 10.1182/blood.V71.2.524.524 / Blood by Koury S. (1988)
  84. 10.1182/blood.V77.11.2497.2497 / Blood by Koury S. T. (1991)
  85. 10.1182/blood.V77.3.419.419 / Blood by Krantz S. B. (1991)
  86. 10.1038/ki.1997.80
  87. 10.1172/JCI113363
  88. 10.1074/jbc.271.17.10405
  89. 10.1016/0378-1119(93)90007-P
  90. 10.1016/0378-1119(93)90567-M
  91. 10.1159/000244033
  92. 10.1203/00006450-199609000-00002
  93. 10.3109/15513819509027024
  94. 10.1182/blood.V84.2.460.460 / Blood by Lim G. B. (1994)
  95. 10.1210/endo.137.5.8612498
  96. 10.1016/0303-7207(95)03736-5
  97. 10.1101/gad.10.2.154
  98. 10.1016/0378-1119(86)90183-6
  99. 10.1006/dbio.1994.1304
  100. 10.1126/science.273.5274.464
  101. 10.1038/369565a0
  102. 10.1038/ng0693-108
  103. 10.1083/jcb.123.6.1305
  104. 10.1056/NEJM199404283301701
  105. 10.1203/00006450-199301000-00013
  106. 10.1007/BF01024870
  107. 10.1111/j.1460-9568.1996.tb01252.x
  108. 10.1101/gad.4.11.1886
  109. 10.1016/S0021-9258(18)82112-3 / J. Biol. Chem. by Masuda S. (1993)
  110. 10.1016/S0021-9258(17)32195-6 / J. Biol. Chem. by Masuda S. (1994)
  111. 10.1182/blood.V84.6.1823.1823 / Blood by Maxwell P. H. (1994)
  112. 10.1677/joe.0.0960311
  113. 10.1016/S0092-8674(00)80165-8
  114. 10.1073/pnas.85.1.247
  115. 10.1046/j.1471-4159.1997.68062530.x
  116. 10.1016/0006-8993(96)00246-6
  117. {'key': 'B118', 'first-page': '157', 'volume': '17', 'author': 'Moritz K.', 'year': '1992', 'journal-title': 'J. Dev. Physiol. (Eynsham)'} / J. Dev. Physiol. (Eynsham) by Moritz K. (1992)
  118. 10.1111/j.1440-1681.1996.tb02584.x
  119. 10.1111/j.1440-1681.1992.tb00496.x
  120. 10.1126/science.257.5073.1138
  121. 10.1126/science.8160019
  122. 10.1126/science.272.5262.722
  123. 10.1182/blood.V81.11.2844.2844 / Blood by Ogawa M. (1993)
  124. 10.1016/0006-8993(94)91455-9
  125. 10.1038/ng0995-40
  126. {'key': 'B128', 'first-page': '660', 'volume': '24', 'author': 'Papayannopoulou T.', 'year': '1996', 'journal-title': 'Exp. Hematol.'} / Exp. Hematol. by Papayannopoulou T. (1996)
  127. 10.1074/jbc.270.52.31282
  128. 10.1111/j.1749-6632.1987.tb36241.x
  129. 10.1242/dev.121.1.163 / Development by Pevny L. (1996)
  130. 10.1038/349257a0
  131. 10.1002/ajh.2830360208
  132. 10.1071/RD9960311
  133. 10.1016/0167-4781(94)90289-5
  134. 10.1002/j.1460-2075.1995.tb07058.x
  135. 10.1038/ki.1997.72
  136. 10.1038/ki.1993.327
  137. 10.1038/173848a0
  138. 10.1182/blood.V74.1.103.103 / Blood by Sawyer S. T. (1989)
  139. {'key': 'B141', 'first-page': '1341', 'volume': '23', 'author': 'Schimmenti L. A.', 'year': '1995', 'journal-title': 'Exp. Hematol.'} / Exp. Hematol. by Schimmenti L. A. (1995)
  140. 10.1101/gad.5.5.728
  141. 10.1111/j.1365-2141.1992.tb08200.x
  142. 10.1038/ki.1997.77
  143. 10.1073/pnas.86.7.2301
  144. 10.1128/MCB.12.12.5447
  145. 10.1038/376062a0
  146. 10.1016/S0022-3476(05)82217-6
  147. 10.1001/archpedi.1994.02170060036006
  148. 10.1073/pnas.94.7.3420
  149. 10.1016/0002-9378(93)90505-D
  150. 10.1016/0012-1606(87)90441-6
  151. {'key': 'B153', 'first-page': '3', 'volume': '7', 'author': 'Stockman J. A.', 'year': '1978', 'journal-title': 'Clin. Hemorheol.'} / Clin. Hemorheol. by Stockman J. A. (1978)
  152. {'issue': '32', 'key': 'B154', 'first-page': 'F474', 'volume': '263', 'author': 'Tan C. C.', 'year': '1992', 'journal-title': 'Am. J. Physiol.'} / Am. J. Physiol. by Tan C. C. (1992)
  153. {'key': 'B155', 'first-page': '795', 'volume': '90', 'author': 'Thomas R. M.', 'year': '1983', 'journal-title': 'J. Obstet. Gynaecol. Res.'} / J. Obstet. Gynaecol. Res. by Thomas R. M. (1983)
  154. 10.1038/339446a0
  155. 10.1073/pnas.92.12.5510
  156. 10.1074/jbc.270.3.1230
  157. 10.1101/gad.8.10.1184
  158. 10.1126/science.273.5274.449
  159. 10.1146/annurev.bi.65.070196.003141
  160. 10.1182/blood.V82.5.1507.1507 / Blood by Wen D. (1993)
  161. 10.1128/MCB.10.12.6596
  162. 10.1016/0300-9629(93)90009-S
  163. 10.1016/S0002-9378(84)80175-1
  164. 10.1016/S0022-3476(05)82459-X
  165. 10.1203/00006450-198906000-00019
  166. {'key': 'B168', 'first-page': '139', 'volume': '15', 'author': 'Widness J. A.', 'year': '1991', 'journal-title': 'J. Dev. Physiol. (Eynsham)'} / J. Dev. Physiol. (Eynsham) by Widness J. A. (1991)
  167. 10.1172/JCI110078
  168. 10.1016/S0022-3565(25)11173-7 / J. Pharmacol. Exp. Ther. by Widness J. A. (1992)
  169. 10.1152/jappl.1996.80.1.140
  170. 10.1542/peds.95.1.9 / Pediatrics by Wilimas J. A. (1995)
  171. 10.1182/blood.V88.9.3349.bloodjournal8893349 / Blood by Wintour E.M. (1996)
  172. {'key': 'B175', 'first-page': '44', 'volume': '22', 'author': 'Wintour E. M.', 'year': '1991', 'journal-title': 'Proc. Aust. Physiol. Pharmacol. Soc.'} / Proc. Aust. Physiol. Pharmacol. Soc. by Wintour E. M. (1991)
  173. 10.1016/0092-8674(93)90414-L
  174. 10.1093/oxfordjournals.bmb.a071376
  175. 10.1126/science.273.5274.458
  176. 10.1016/0092-8674(95)90234-1
  177. 10.1111/j.1432-1033.1996.0494u.x
  178. 10.1111/j.1440-169X.1993.00711.x
  179. 10.1038/348647a0
  180. 10.1182/blood.V81.9.2223.2223 / Blood by Youssoufian H. (1993)
  181. 10.1038/330765a0
  182. 10.1046/j.1537-2995.1989.29189101164.x
  183. {'key': 'B187', 'first-page': '330', 'volume': '24', 'author': 'Zimmermann F.', 'year': '1996', 'journal-title': 'Exp. Hematol.'} / Exp. Hematol. by Zimmermann F. (1996)
Dates
Type When
Created 7 years, 8 months ago (Dec. 24, 2017, 7:21 p.m.)
Deposited 2 months, 1 week ago (June 29, 2025, 1:34 a.m.)
Indexed 2 months, 1 week ago (June 29, 2025, 2:10 a.m.)
Issued 27 years, 9 months ago (Dec. 1, 1997)
Published 27 years, 9 months ago (Dec. 1, 1997)
Published Print 27 years, 9 months ago (Dec. 1, 1997)
Funders 0

None

@article{Moritz_1997, title={Developmental regulation of erythropoietin and erythropoiesis}, volume={273}, ISSN={1522-1490}, url={http://dx.doi.org/10.1152/ajpregu.1997.273.6.r1829}, DOI={10.1152/ajpregu.1997.273.6.r1829}, number={6}, journal={American Journal of Physiology-Regulatory, Integrative and Comparative Physiology}, publisher={American Physiological Society}, author={Moritz, K. M. and Lim, Gaik Bee and Wintour, E. M.}, year={1997}, month=dec, pages={R1829–R1844} }