DOI: 10.1152/ajpregu.00735.2001. Sleep deprivation decreases glycogen in the cerebellum but not in the cortex of young rats

Sleep deprivation decreases glycogen in the cerebellum but not in the cortex of young rats

10.1152/ajpregu.00735.2001

Crossref journal-article

American Physiological Society

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (24)

Abstract

We tested whether brain glycogen reserves were depleted by sleep deprivation (SD) in Long-Evans rats 20–59 days old. Animals were sleep deprived beginning at lights on and then immediately killed by microwave irradiation. Glycogen and glucose levels were measured by a fluorescence enzymatic assay. In all age groups, SD reduced cerebellar glycogen levels by an average of 26% after 6 h of SD. No changes were observed in the cortex after 6 h of SD, but in the oldest animals, 12 h of SD increased cortical glycogen levels. There was a developmental increase in basal glycogen levels in both the cortex and cerebellum that peaked at 34 days and declined thereafter. Robust differences in cortical and cerebellar glycogen levels in response to enforced waking may reflect regional differences in energy utilization and regulation during wakefulness. These results show that brain glycogen reserves are sensitive to SD.

Bibliography

Gip, P., Hagiwara, G., Ruby, N. F., & Heller, H. C. (2002). Sleep deprivation decreases glycogen in the cerebellum but not in the cortex of young rats. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 283(1), R54âR59.

Authors 4

Phung Gip (first)
Grace Hagiwara (additional)
Norman F. Ruby (additional)
H. Craig Heller (additional)

References 43 Referenced 44

10.1152/ajpregu.1990.258.3.R634
10.1002/(SICI)1098-1136(200006)30:4<382::AID-GLIA70>3.0.CO;2-0
10.1016/0301-0082(94)00057-O
10.1016/0006-8993(95)00590-M
{'key': 'B5', 'first-page': '195', 'volume': '1', 'author': 'Borbely AA.', 'year': '1982', 'journal-title': 'Hum Neurobiol'} / Hum Neurobiol by Borbely AA. (1982)
10.1074/jbc.272.32.20198
10.1111/j.1471-4159.1971.tb00186.x
10.1016/0006-8993(93)91651-8
10.1159/000111333
10.1152/ajpregu.1984.246.2.R161
10.1016/0165-0270(95)00119-0
10.1152/ajpregu.1998.275.1.R148
10.1152/ajpregu.1991.261.1.R198
10.1016/0006-8993(92)91708-M
{'key': 'B16', 'first-page': '213', 'volume': '48', 'author': 'Gross PM', 'year': '1980', 'journal-title': 'J Appl Physiol Respir Environ Exercise Physiol'} / J Appl Physiol Respir Environ Exercise Physiol by Gross PM (1980)
{'key': 'B17', 'first-page': '1755', 'volume': '26', 'author': 'Holden CP', 'year': '2000', 'journal-title': 'Soc Neurosci Abstr'} / Soc Neurosci Abstr by Holden CP (2000)
{'key': 'B18', 'first-page': '1', 'volume': '52', 'author': 'Ibrahim MZM', 'year': '1975', 'journal-title': 'Adv Anat Embryol Cell Biol'} / Adv Anat Embryol Cell Biol by Ibrahim MZM (1975)
10.1111/j.1471-4159.1983.tb00853.x
10.1007/BF00965901
10.1111/j.1471-4159.1977.tb07768.x
10.1038/jcbfm.1995.60 / J Cereb Blood Flow Metab by Madsen PL (1995)
10.1046/j.1365-2869.2000.00214.x
10.1016/0006-8993(76)90290-0
10.1016/0197-0186(89)90004-1
10.1016/0301-0082(93)90022-K
10.1523/JNEUROSCI.08-07-02321.1988
10.1111/j.1471-4159.1968.tb05904.x
10.1016/0003-2697(74)90248-6
{'key': 'B30', 'first-page': '2027', 'volume': '26', 'author': 'Petit J', 'year': '2000', 'journal-title': 'Soc Neurosci Abstr'} / Soc Neurosci Abstr by Petit J (2000)
10.1007/BF00270045
10.3109/07853899908998788
10.1126/science.276.5316.1265
10.1126/science.275.5305.1475
10.1093/sleep/6.3.196
10.1016/0006-8993(87)90195-8
10.1016/0014-2999(96)00021-0
10.1139/y92-255
10.1016/0306-4522(92)90329-Z
10.1080/01616412.1989.11739856
10.1097/00004647-199607000-00025
10.1111/j.1471-4159.1973.tb00272.x
10.1002/(SICI)1098-1136(199709)21:1<22::AID-GLIA3>3.0.CO;2-3
10.1007/BF02026342

Dates

Type	When
Created	10 years, 6 months ago (March 3, 2015, 3:24 p.m.)
Deposited	5 years, 11 months ago (Sept. 8, 2019, 11:23 a.m.)
Indexed	4 months, 1 week ago (April 22, 2025, 4:30 a.m.)
Issued	23 years, 2 months ago (July 1, 2002)
Published	23 years, 2 months ago (July 1, 2002)
Published Print	23 years, 2 months ago (July 1, 2002)

Funders 0

None

BibTeX

@article{Gip_2002, title={Sleep deprivation decreases glycogen in the cerebellum but not in the cortex of young rats}, volume={283}, ISSN={1522-1490}, url={http://dx.doi.org/10.1152/ajpregu.00735.2001}, DOI={10.1152/ajpregu.00735.2001}, number={1}, journal={American Journal of Physiology-Regulatory, Integrative and Comparative Physiology}, publisher={American Physiological Society}, author={Gip, Phung and Hagiwara, Grace and Ruby, Norman F. and Heller, H. Craig}, year={2002}, month=jul, pages={R54–R59} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        4,
        22
      ]
    ],
    "date-time": "2025-04-22T08:30:23Z",
    "timestamp": 1745310623942
  },
  "reference-count": 43,
  "publisher": "American Physiological Society",
  "issue": "1",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2002,
        7,
        1
      ]
    ]
  },
  "abstract": "<jats:p> We tested whether brain glycogen reserves were depleted by sleep deprivation (SD) in Long-Evans rats 20\u201359 days old. Animals were sleep deprived beginning at lights on and then immediately killed by microwave irradiation. Glycogen and glucose levels were measured by a fluorescence enzymatic assay. In all age groups, SD reduced cerebellar glycogen levels by an average of 26% after 6 h of SD. No changes were observed in the cortex after 6 h of SD, but in the oldest animals, 12 h of SD increased cortical glycogen levels. There was a developmental increase in basal glycogen levels in both the cortex and cerebellum that peaked at 34 days and declined thereafter. Robust differences in cortical and cerebellar glycogen levels in response to enforced waking may reflect regional differences in energy utilization and regulation during wakefulness. These results show that brain glycogen reserves are sensitive to SD. </jats:p>",
  "DOI": "10.1152/ajpregu.00735.2001",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2015,
        3,
        3
      ]
    ],
    "date-time": "2015-03-03T20:24:31Z",
    "timestamp": 1425414271000
  },
  "page": "R54-R59",
  "source": "Crossref",
  "is-referenced-by-count": 44,
  "title": "Sleep deprivation decreases glycogen in the cerebellum  but not in the cortex of young rats",
  "prefix": "10.1152",
  "volume": "283",
  "author": [
    {
      "given": "Phung",
      "family": "Gip",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Department of Biological Sciences, Stanford University, Stanford, California 94305"
        }
      ]
    },
    {
      "given": "Grace",
      "family": "Hagiwara",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Biological Sciences, Stanford University, Stanford, California 94305"
        }
      ]
    },
    {
      "given": "Norman F.",
      "family": "Ruby",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Biological Sciences, Stanford University, Stanford, California 94305"
        }
      ]
    },
    {
      "given": "H. Craig",
      "family": "Heller",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Biological Sciences, Stanford University, Stanford, California 94305"
        }
      ]
    }
  ],
  "member": "24",
  "reference": [
    {
      "key": "B1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1152/ajpregu.1990.258.3.R634"
    },
    {
      "key": "B2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/(SICI)1098-1136(200006)30:4<382::AID-GLIA70>3.0.CO;2-0"
    },
    {
      "key": "B3",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0301-0082(94)00057-O"
    },
    {
      "key": "B4",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0006-8993(95)00590-M"
    },
    {
      "key": "B5",
      "first-page": "195",
      "volume": "1",
      "author": "Borbely AA.",
      "year": "1982",
      "journal-title": "Hum Neurobiol"
    },
    {
      "key": "B6",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.272.32.20198"
    },
    {
      "key": "B7",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1471-4159.1971.tb00186.x"
    },
    {
      "key": "B8",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0006-8993(93)91651-8"
    },
    {
      "key": "B9",
      "doi-asserted-by": "publisher",
      "DOI": "10.1159/000111333"
    },
    {
      "key": "B11",
      "doi-asserted-by": "publisher",
      "DOI": "10.1152/ajpregu.1984.246.2.R161"
    },
    {
      "key": "B12",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0165-0270(95)00119-0"
    },
    {
      "key": "B13",
      "doi-asserted-by": "publisher",
      "DOI": "10.1152/ajpregu.1998.275.1.R148"
    },
    {
      "key": "B14",
      "doi-asserted-by": "publisher",
      "DOI": "10.1152/ajpregu.1991.261.1.R198"
    },
    {
      "key": "B15",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0006-8993(92)91708-M"
    },
    {
      "key": "B16",
      "first-page": "213",
      "volume": "48",
      "author": "Gross PM",
      "year": "1980",
      "journal-title": "J Appl Physiol Respir Environ Exercise Physiol"
    },
    {
      "key": "B17",
      "first-page": "1755",
      "volume": "26",
      "author": "Holden CP",
      "year": "2000",
      "journal-title": "Soc Neurosci Abstr"
    },
    {
      "key": "B18",
      "first-page": "1",
      "volume": "52",
      "author": "Ibrahim MZM",
      "year": "1975",
      "journal-title": "Adv Anat Embryol Cell Biol"
    },
    {
      "key": "B19",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1471-4159.1983.tb00853.x"
    },
    {
      "key": "B20",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00965901"
    },
    {
      "key": "B21",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1471-4159.1977.tb07768.x"
    },
    {
      "key": "B22",
      "doi-asserted-by": "crossref",
      "first-page": "577",
      "DOI": "10.1038/jcbfm.1995.60",
      "volume": "15",
      "author": "Madsen PL",
      "year": "1995",
      "journal-title": "J Cereb Blood Flow Metab"
    },
    {
      "key": "B23",
      "doi-asserted-by": "publisher",
      "DOI": "10.1046/j.1365-2869.2000.00214.x"
    },
    {
      "key": "B24",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0006-8993(76)90290-0"
    },
    {
      "key": "B25",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0197-0186(89)90004-1"
    },
    {
      "key": "B26",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0301-0082(93)90022-K"
    },
    {
      "key": "B27",
      "doi-asserted-by": "publisher",
      "DOI": "10.1523/JNEUROSCI.08-07-02321.1988"
    },
    {
      "key": "B28",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1471-4159.1968.tb05904.x"
    },
    {
      "key": "B29",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0003-2697(74)90248-6"
    },
    {
      "key": "B30",
      "first-page": "2027",
      "volume": "26",
      "author": "Petit J",
      "year": "2000",
      "journal-title": "Soc Neurosci Abstr"
    },
    {
      "key": "B31",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00270045"
    },
    {
      "key": "B32",
      "doi-asserted-by": "publisher",
      "DOI": "10.3109/07853899908998788"
    },
    {
      "key": "B33",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.276.5316.1265"
    },
    {
      "key": "B34",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.275.5305.1475"
    },
    {
      "key": "B35",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/sleep/6.3.196"
    },
    {
      "key": "B36",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0006-8993(87)90195-8"
    },
    {
      "key": "B37",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0014-2999(96)00021-0"
    },
    {
      "key": "B38",
      "doi-asserted-by": "publisher",
      "DOI": "10.1139/y92-255"
    },
    {
      "key": "B39",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0306-4522(92)90329-Z"
    },
    {
      "key": "B40",
      "doi-asserted-by": "publisher",
      "DOI": "10.1080/01616412.1989.11739856"
    },
    {
      "key": "B42",
      "doi-asserted-by": "publisher",
      "DOI": "10.1097/00004647-199607000-00025"
    },
    {
      "key": "B43",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1471-4159.1973.tb00272.x"
    },
    {
      "key": "B44",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/(SICI)1098-1136(199709)21:1<22::AID-GLIA3>3.0.CO;2-3"
    },
    {
      "key": "B45",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF02026342"
    }
  ],
  "container-title": "American Journal of Physiology-Regulatory, Integrative and Comparative Physiology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.physiology.org/doi/pdf/10.1152/ajpregu.00735.2001",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2019,
        9,
        8
      ]
    ],
    "date-time": "2019-09-08T15:23:06Z",
    "timestamp": 1567956186000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.physiology.org/doi/10.1152/ajpregu.00735.2001"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2002,
        7,
        1
      ]
    ]
  },
  "references-count": 43,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          2002,
          7,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1152/ajpregu.00735.2001"
  ],
  "URL": "http://dx.doi.org/10.1152/ajpregu.00735.2001",
  "relation": {},
  "ISSN": [
    "0363-6119",
    "1522-1490"
  ],
  "subject": [],
  "container-title-short": "American Journal of Physiology-Regulatory, Integrative and Comparative Physiology",
  "published": {
    "date-parts": [
      [
        2002,
        7,
        1
      ]
    ]
  }
}