DOI: 10.1152/ajpregu.00297.2004. Relationship between body size, Na<sup>+</sup>-K<sup>+</sup>-ATPase activity, and membrane lipid composition in mammal and bird kidney

Relationship between body size, Na+-K+-ATPase activity, and membrane lipid composition in mammal and bird kidney

10.1152/ajpregu.00297.2004

Crossref journal-article

American Physiological Society

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (24)

Abstract

We investigated the relationship between body size, Na+-K+-ATPase molecular activity, and membrane lipid composition in the kidney of five mammalian and eight avian species ranging from 30-g mice to 280-kg cattle and 13-g zebra finches to 35-kg emus, respectively. Na+-K+-ATPase activity was found to be higher in the smaller species of both groups. In small mammals, the higher Na+-K+-ATPase activity was primarily the result of an increase in the molecular activity (turnover rate) of individual enzymes, whereas in small birds the higher Na+-K+-ATPase activity was the result of an increased enzyme concentration. Phospholipids from both mammals and birds contained a relatively constant percentage of unsaturated fatty acids; however, phospholipids from the smaller species were generally more polyunsaturated, and a complementary significant allometric increase in monounsaturate content was observed in the larger species. In particular, the relative content of the highly polyunsaturated docosahexaenoic acid [22:6( n-3)] displayed the greatest variation with body mass, scaling with allometric exponents of −0.21 and −0.26 in the mammals and birds, respectively. This allometric variation in fatty acid composition was correlated with Na+-K+-ATPase molecular activity in mammals, whereas in birds molecular activity only correlated with membrane cholesterol content. These relationships are discussed with respect to the metabolic intensity of different-sized animals.

Bibliography

Turner, N., Haga, K. L., Hulbert, A. J., & Else, P. L. (2005). Relationship between body size, Na+-K+-ATPase activity, and membrane lipid composition in mammal and bird kidney. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 288(1), R301âR310.

Authors 4

Nigel Turner (first)
Kurt L. Haga (additional)
A. J. Hulbert (additional)
Paul L. Else (additional)

References 47 Referenced 29

Altman PLand Dittmer DS.Biology Data Book.Bethesda, MD: FASEB, 1974.
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10.1042/bj2750081
10.1042/bj20030984
Brody S.Bioenergetics and Growth. New York: Reinhold, 1945.
10.1016/S0305-0491(97)00357-X
10.1152/physrev.1991.71.3.733
10.1007/BF00234153
10.1152/ajpregu.1995.268.3.R641
10.1007/s003600050083
10.1152/ajpregu.1994.267.3.R754
10.1242/jeb.01017
10.1007/BF00692920
10.1152/ajpregu.1987.253.1.R1
10.1152/ajpregu.1996.271.5.R1287
10.1007/s003600050224
10.1016/0005-2736(88)90504-4
Folch J, Less M, and Stanley GHS.A simple method for the isolation and purification of total lipids from animal tissues.J Biol Chem226: 497–509, 1957. (10.1016/S0021-9258(18)64849-5)
10.1152/ajpheart.1983.245.4.H567
Horisberger J-D.The Na,K-ATPase: Structure: Function Relationships. Boca Raton, FL: CRC, 1994.
10.1152/ajpregu.1989.256.1.R63
10.1006/jtbi.1999.0955
10.1146/annurev.physiol.62.1.207
Hulbert AJ, Faulks S, Buttemer WA, and Else PL.Acyl composition of muscle membranes varies with body size in birds.J Exp Biol205: 3561–3569, 2002. (10.1242/jeb.205.22.3561)
10.1016/S1096-4959(02)00066-0
Hulbert AJ, Turner N, Storlien LH, and Else PL.Dietary fats and membrane function: implications for metabolism and disease.Biol RevIn press.
10.1152/physrev.1980.60.3.864
10.1038/ki.1986.3
10.1146/annurev.biochem.71.102201.141218
Kleiber M.The Fire of Life. An Introduction to Animal Energetics.New York: Wiley, 1961.
10.1016/0006-3002(50)90032-1
10.2307/1366368
Mills GL, Lane PA, and Weech PK.A guidebook to lipoprotein technique. In:Laboratory Techniques in Biochemistry and Molecular Biology, edited by Burdon RH and van Knippenberg PH. New York: Elsevier, 1984, p. 240–241.
Munro HN.Evolution of protein metabolism in mammals. In:Mammalian Protein Metabolism, edited by Munro HN. New York: Academic, 1969, p. 133–182.
10.1093/jn/123.3.512
Peters RH.The Ecological Implications of Body Size. Cambridge, UK: Cambridge Univ Press, 1983. (10.1017/CBO9780511608551)
10.1152/ajpregu.1995.269.5.R1213
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Prosser CL.Inorganic Ions. In:Comparative Animal Physiology Environmental Physiology, edited by Prosser CL. Philadelphia, PA: Saunders, 1973, \?\vol. I, p. 79–105.
10.1152/physrev.1997.77.3.731
Rubner M.Ueber den Einfluss der Korpergrosse auf Stoff-und Kraftwechsel.Z Biol19: 535–562, 1883.
10.1006/abbi.1995.1279
10.1016/S1388-1981(00)00077-9
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10.1007/s00114-003-0470-z
10.1016/0003-9861(80)90448-8
10.1152/ajpcell.00486.2003

Dates

Type	When
Created	20 years, 10 months ago (Sept. 30, 2004, 8:33 p.m.)
Deposited	4 years, 2 months ago (June 25, 2021, 10:55 p.m.)
Indexed	1 year, 1 month ago (July 16, 2024, 11:04 a.m.)
Issued	20 years, 7 months ago (Jan. 1, 2005)
Published	20 years, 7 months ago (Jan. 1, 2005)
Published Print	20 years, 7 months ago (Jan. 1, 2005)

Funders 0

None

BibTeX

@article{Turner_2005, title={Relationship between body size, Na+-K+-ATPase activity, and membrane lipid composition in mammal and bird kidney}, volume={288}, ISSN={1522-1490}, url={http://dx.doi.org/10.1152/ajpregu.00297.2004}, DOI={10.1152/ajpregu.00297.2004}, number={1}, journal={American Journal of Physiology-Regulatory, Integrative and Comparative Physiology}, publisher={American Physiological Society}, author={Turner, Nigel and Haga, Kurt L. and Hulbert, A. J. and Else, Paul L.}, year={2005}, month=jan, pages={R301–R310} }

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