DOI: 10.1152/ajplegacy.1961.200.5.987. Mechanism of histamine release in endotoxin shock

Mechanism of histamine release in endotoxin shock

10.1152/ajplegacy.1961.200.5.987

Crossref journal-article

American Physiological Society

American Journal of Physiology-Legacy Content (24)

Abstract

Reports from this laboratory have dealt with hemodynamic changes after injection of endotoxin and the role of histamine in endotoxin shock. This study relates to the mechanism of histamine release. Anesthetized dogs were administered lethal doses of E. coli endotoxin. During the course of the subsequent hypotension, simultaneous increases of blood histamine, histamine-histidine ratio(H/Hd), and circulating hematocrit were observed. Results suggest that a conversion from histidine to histamine occurs at an accelerated rate following endotoxin administration. These findings give further evidence for the active role of histamine in endotoxin shock and support a hypothesis recently proposed by Schayer.

Bibliography

Hinshaw, L. B., Jordan, M. M., & Vick, J. A. (1961). Mechanism of histamine release in endotoxin shock. American Journal of Physiology-Legacy Content, 200(5), 987â989.

Authors 3

Lerner B. Hinshaw (first)
Margaret M. Jordan (additional)
James A. Vick (additional)

References 0 Referenced 43

None

Dates

Type	When
Created	7 years, 8 months ago (Dec. 22, 2017, 12:10 a.m.)
Deposited	5 years, 11 months ago (Sept. 8, 2019, 1:06 p.m.)
Indexed	4 months, 3 weeks ago (April 10, 2025, 7:32 a.m.)
Issued	64 years, 4 months ago (May 1, 1961)
Published	64 years, 4 months ago (May 1, 1961)
Published Print	64 years, 4 months ago (May 1, 1961)

Funders 0

None

BibTeX

@article{Hinshaw_1961, title={Mechanism of histamine release in endotoxin shock}, volume={200}, ISSN={0002-9513}, url={http://dx.doi.org/10.1152/ajplegacy.1961.200.5.987}, DOI={10.1152/ajplegacy.1961.200.5.987}, number={5}, journal={American Journal of Physiology-Legacy Content}, publisher={American Physiological Society}, author={Hinshaw, Lerner B. and Jordan, Margaret M. and Vick, James A.}, year={1961}, month=may, pages={987–989} }

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