DOI: 10.1152/ajplegacy.1961.200.2.297. Identification of a reticuloendothelial stimulating agent in zymosan

Identification of a reticuloendothelial stimulating agent in zymosan

10.1152/ajplegacy.1961.200.2.297

Crossref journal-article

American Physiological Society

American Journal of Physiology-Legacy Content (24)

Abstract

The functional activity of the reticuloendothelial system (RES), as determined by the intravascular clearance of colloidal carbon, and the degree of induced RE hyperplasia were studied following the intravenous injection of various constituents of zymosan. The readily extractable lipid component from the yeast cell wall was inactive, as was the polysaccharide, mannan. Stimulatory activity was still present in the zymosan residue after removal of free and bound lipids. The administration of glucan derived either from yeast, or its cell wall, resulted in marked RE activation and induced hyperplasia, demonstrating it to be the active RE stimulating agent. The relationship of glucan's chemical structure to its ability to induce RE hyperfunction and hyperplasia is discussed.

Bibliography

Riggi, S. J., & Di Luzio, N. R. (1961). Identification of a reticuloendothelial stimulating agent in zymosan. American Journal of Physiology-Legacy Content, 200(2), 297â300.

Authors 2

S. J. Riggi (first)
N. R. Di Luzio (additional)

References 0 Referenced 158

None

Dates

Type	When
Created	7 years, 8 months ago (Dec. 21, 2017, 11:01 p.m.)
Deposited	5 years, 11 months ago (Sept. 8, 2019, 12:57 p.m.)
Indexed	2 months, 4 weeks ago (May 25, 2025, 11:40 a.m.)
Issued	64 years, 6 months ago (Feb. 1, 1961)
Published	64 years, 6 months ago (Feb. 1, 1961)
Published Print	64 years, 6 months ago (Feb. 1, 1961)

Funders 0

None

BibTeX

@article{Riggi_1961, title={Identification of a reticuloendothelial stimulating agent in zymosan}, volume={200}, ISSN={0002-9513}, url={http://dx.doi.org/10.1152/ajplegacy.1961.200.2.297}, DOI={10.1152/ajplegacy.1961.200.2.297}, number={2}, journal={American Journal of Physiology-Legacy Content}, publisher={American Physiological Society}, author={Riggi, S. J. and Di Luzio, N. R.}, year={1961}, month=feb, pages={297–300} }

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