DOI: 10.1152/ajpheart.2001.280.2.h554. Estimation of left ventricular operating stiffness from Doppler early filling deceleration time in humans

Estimation of left ventricular operating stiffness from Doppler early filling deceleration time in humans

10.1152/ajpheart.2001.280.2.h554

Crossref journal-article

American Physiological Society

American Journal of Physiology-Heart and Circulatory Physiology (24)

Abstract

Shortened early transmitral deceleration times ( E DT) have been qualitatively associated with increased filling pressure and reduced survival in patients with cardiac disease and increased left ventricular operating stiffness ( K LV). An equation relating K LV quantitatively to E DT has previously been described in a canine model but not in humans. During several varying hemodynamic conditions, we studied 18 patients undergoing open-heart surgery. Transesophageal echocardiographic two-dimensional volumes and Doppler flows were combined with high-fidelity left atrial (LA) and left ventricular (LV) pressures to determine K LV. From digitized Doppler recordings, E DT was measured and compared against changes in LV and LA diastolic volumes and pressures. E DT(180 ± 39 ms) was inversely associated with LV end-diastolic pressures ( r = −0.56, P = 0.004) and net atrioventricular stiffness ( r = −0.55, P = 0.006) but had its strongest association with K LV ( r = −0.81, P < 0.001). K LV was predicted assuming a nonrestrictive orifice ( K nonrest) from E DT as K nonrest= (0.07/ E DT)2 with K LV = 1.01 K nonrest − 0.02; r = 0.86, P < 0.001, Δ K( K nonrest − K LV) = 0.02 ± 0.06 mmHg/ml. In adults with cardiac disease, E DT provides an accurate estimate of LV operating stiffness and supports its application as a practical noninvasive index in the evaluation of diastolic function.

Bibliography

Garcia, M. J., Firstenberg, M. S., Greenberg, N. L., Smedira, N., Rodriguez, L., Prior, D., & Thomas, J. D. (2001). Estimation of left ventricular operating stiffness from Doppler early filling deceleration time in humans. American Journal of Physiology-Heart and Circulatory Physiology, 280(2), H554âH561.

Authors 7

Mario J. Garcia (first)
Michael S. Firstenberg (additional)
Neil L. Greenberg (additional)
Nicholas Smedira (additional)
Leonardo Rodriguez (additional)
David Prior (additional)
James D. Thomas (additional)

References 27 Referenced 70

Dates

Type	When
Created	7 years, 8 months ago (Dec. 21, 2017, 10:49 p.m.)
Deposited	5 years, 11 months ago (Sept. 8, 2019, 9:35 a.m.)
Indexed	4 months, 2 weeks ago (April 12, 2025, 8:52 p.m.)
Issued	24 years, 6 months ago (Feb. 1, 2001)
Published	24 years, 6 months ago (Feb. 1, 2001)
Published Print	24 years, 6 months ago (Feb. 1, 2001)

Funders 0

None

BibTeX

@article{Garcia_2001, title={Estimation of left ventricular operating stiffness from Doppler early filling deceleration time in humans}, volume={280}, ISSN={1522-1539}, url={http://dx.doi.org/10.1152/ajpheart.2001.280.2.h554}, DOI={10.1152/ajpheart.2001.280.2.h554}, number={2}, journal={American Journal of Physiology-Heart and Circulatory Physiology}, publisher={American Physiological Society}, author={Garcia, Mario J. and Firstenberg, Michael S. and Greenberg, Neil L. and Smedira, Nicholas and Rodriguez, Leonardo and Prior, David and Thomas, James D.}, year={2001}, month=feb, pages={H554–H561} }

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