DOI: 10.1152/ajpendo.1978.235.2.e231. Effects of thyroxine on protein turnover in rat skeletal muscle.

Effects of thyroxine on protein turnover in rat skeletal muscle.

10.1152/ajpendo.1978.235.2.e231

Crossref journal-article

American Physiological Society

American Journal of Physiology-Endocrinology and Metabolism (24)

Abstract

The effects of thyroxine (T4) on protein turnover in skeletal muscle were studied using normal, thyroidectomized (thyrex), and hypophysectomized (hypox) rats. Thyrex rats had a depressed growth rate that was accompanied by 50% reductions in the level of RNA and the rate of protein synthesis in gastrocnemius muscle, as determined in the perfused hemicorpus. Protein synthetic efficiency (protein synthesis per unit RNA) was decreased by 18%. Daily treatment of thyrex rats with T4 at different dose levels for up to 16 days led to improved growth rates, elevated RNA concentrations, and increased protein synthesis rates. The primary effect of T4 was to increase the protein synthetic capacity of muscle. Protein degradation, determined in the perfused hemicorpus, and activity of a lysosomal protease, determined in unperfused muscle, were reduced in the thyrex condition. Treatment of thyrex rats with T4 increased protein degradative rates, but not protease activity. Hypox rats, which also exhibited depressed skeletal muscle protein synthesis, responded to T4 and combined T4 and growth hormone with marked improvements in protein synthesis.

Bibliography

Flaim, K. E., Li, J. B., & Jefferson, L. S. (1978). Effects of thyroxine on protein turnover in rat skeletal muscle. American Journal of Physiology-Endocrinology and Metabolism, 235(2), E231.

Authors 3

K E Flaim (first)
J B Li (additional)
L S Jefferson (additional)

References 23 Referenced 11

{'key': 'p_3', 'first-page': '379', 'volume': '43', 'author': 'CL C', 'year': '1973', 'journal-title': 'Acta'} / Acta by CL C (1973)
10.1111/j.1365-2265.1977.tb03319.x
10.1210/endo-78-6-1252
{'key': 'p_7', 'first-page': '306', 'volume': '117', 'author': 'CHEEK D. E.', 'year': '1965', 'journal-title': 'Bull. Johns Hopkins Hosp.'} / Bull. Johns Hopkins Hosp. by CHEEK D. E. (1965)
{'key': 'p_8', 'first-page': '527', 'volume': '36', 'author': 'DEMARTINO G. N.', 'year': '1977', 'journal-title': 'Federation Proc.'} / Federation Proc. by DEMARTINO G. N. (1977)
{'key': 'p_9', 'first-page': 'E38', 'volume': '234', 'author': 'FLAIM K. E', 'year': '1978', 'journal-title': 'Am. J. Physiol.'} / Am. J. Physiol. by FLAIM K. E (1978)
10.1016/0006-3002(62)90836-3
10.1016/S0021-9258(19)41337-9 / J. Bill. Chem. by HJALMARSON A. C. (1975)
10.1016/S0076-6879(75)39011-3
10.1016/S0021-9258(17)40681-8 / Biol. Chem. by JEFFERSON L. S.
10.1042/bj1500235 / Biochem. J. by KING D. B. (1975)
10.1016/0016-6480(76)90030-7
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10.1016/S0076-6879(57)03413-8
10.1016/S0021-9258(19)44302-0 / J. Bill. Chem. by MATHEWS R. W. (1973)
10.1016/S0021-9258(17)38107-3 / J. Biol. Chem. by MCKEE E. E. (1978)
10.1042/bj1560185
10.1016/S0021-9258(19)77202-0 / J. Biol. Chem. by MILLWARD D. J. (1971)
10.1016/S0021-9258(19)77203-2 / Biol. Chem. by MORGAN H. E. (1971)
10.1016/S0076-6879(75)37020-1
10.1210/endo-55-3-344
10.1152/ajplegacy.1959.196.4.859 / Am. J. Physiol. by SCOW R. (1959)
10.1038/249478a0

Dates

Type	When
Created	7 years, 7 months ago (Dec. 25, 2017, 12:56 a.m.)
Deposited	3 years ago (Aug. 11, 2022, 1:46 a.m.)
Indexed	22 hours, 15 minutes ago (Aug. 23, 2025, 9:44 p.m.)
Issued	47 years ago (Aug. 1, 1978)
Published	47 years ago (Aug. 1, 1978)
Published Print	47 years ago (Aug. 1, 1978)

Funders 0

None

BibTeX

@article{Flaim_1978, title={Effects of thyroxine on protein turnover in rat skeletal muscle.}, volume={235}, ISSN={1522-1555}, url={http://dx.doi.org/10.1152/ajpendo.1978.235.2.e231}, DOI={10.1152/ajpendo.1978.235.2.e231}, number={2}, journal={American Journal of Physiology-Endocrinology and Metabolism}, publisher={American Physiological Society}, author={Flaim, K E and Li, J B and Jefferson, L S}, year={1978}, month=aug, pages={E231} }

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