DOI: 10.1152/ajpcell.2001.280.1.c46. Desmin integrates the three-dimensional mechanical properties of muscles

Desmin integrates the three-dimensional mechanical properties of muscles

10.1152/ajpcell.2001.280.1.c46

Crossref journal-article

American Physiological Society

American Journal of Physiology-Cell Physiology (24)

Abstract

Striated muscle is a linear motor whose properties have been defined in terms of uniaxial structures. The question addressed here is what contribution is made to the properties of this motor by extramyofilament cytoskeletal structures that are not aligned in parallel with the myofilaments. This question arose from observations that transverse loads increase muscle force production in diaphragm but not in the hindlimb muscle, thereby indicating the presence of structures that couple longitudinal and transverse properties of diaphragmatic muscle. Furthermore, we find that the diaphragms of null mutants for the cytoskeletal protein desmin show 1) significant reductions in coupling between the longitudinal and transverse properties, indicating for the first time a role for a specific protein in integrating the three-dimensional mechanical properties of muscle, 2) significant reductions in the stiffness and viscoelasticity of muscle, and 3) significant increases in tetanic force production. Thus desmin serves a complex mechanical function in diaphragm muscle by contributing both to passive stiffness and viscoelasticity and to modulation of active force production in a three-dimensional structural network. Our finding changes the paradigm of force transmission among cells by placing our understanding of the function of the cytoskeleton in the context of the structural and mechanical complexity of muscles.

Bibliography

Boriek, A. M., Capetanaki, Y., Hwang, W., Officer, T., Badshah, M., Rodarte, J., & Tidball, J. G. (2001). Desmin integrates the three-dimensional mechanical properties of muscles. American Journal of Physiology-Cell Physiology, 280(1), C46âC52.

Authors 7

Aladin M. Boriek (first)
Y. Capetanaki (additional)
Willy Hwang (additional)
Todd Officer (additional)
Muffasir Badshah (additional)
Joe Rodarte (additional)
James G. Tidball (additional)

References 21 Referenced 82

10.1152/jappl.2000.89.6.2187
10.1152/jappl.1998.84.1.318
10.1152/ajpregu.2001.280.1.R33
10.1152/jappl.1994.76.1.223
10.1016/0003-2697(81)90281-5
10.1152/jappl.1988.65.5.2253
{'key': 'B7', 'first-page': '89', 'volume': '119', 'author': 'Faulkner JA', 'year': '1979', 'journal-title': 'Am Rev Respir Dis'} / Am Rev Respir Dis by Faulkner JA (1979)
10.1249/00003677-199600240-00016
10.1083/jcb.109.2.517
{'key': 'B11', 'first-page': '319', 'volume': '31', 'author': 'Herrmann H', 'year': '1998', 'journal-title': 'Subcell Biochem'} / Subcell Biochem by Herrmann H (1998)
10.1038/227680a0
10.1152/jappl.1994.76.5.2070
10.1083/jcb.134.5.1255
10.1002/cm.970030102 / Cell Muscle Motil by Price MG (1983)
10.1016/0034-5687(70)90054-X
10.1002/bies.950150906
10.1002/jcp.1041140314
10.1016/0021-9290(91)90376-X
10.1016/0014-4827(92)90425-8
10.1083/jcb.96.6.1727
10.1016/0955-0674(91)90173-V

Dates

Type	When
Created	7 years, 8 months ago (Dec. 24, 2017, 5:55 p.m.)
Deposited	1 year, 2 months ago (June 17, 2024, 3:15 p.m.)
Indexed	3 days, 22 hours ago (Aug. 21, 2025, 1:02 p.m.)
Issued	24 years, 7 months ago (Jan. 1, 2001)
Published	24 years, 7 months ago (Jan. 1, 2001)
Published Print	24 years, 7 months ago (Jan. 1, 2001)

Funders 0

None

BibTeX

@article{Boriek_2001, title={Desmin integrates the three-dimensional mechanical properties of muscles}, volume={280}, ISSN={1522-1563}, url={http://dx.doi.org/10.1152/ajpcell.2001.280.1.c46}, DOI={10.1152/ajpcell.2001.280.1.c46}, number={1}, journal={American Journal of Physiology-Cell Physiology}, publisher={American Physiological Society}, author={Boriek, Aladin M. and Capetanaki, Y. and Hwang, Willy and Officer, Todd and Badshah, Muffasir and Rodarte, Joe and Tidball, James G.}, year={2001}, month=jan, pages={C46–C52} }

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