G Proteins and Phototransduction
10.1146/annurev.physiol.64.082701.102229
Crossref journal-article
Annual Reviews
Annual Review of Physiology (22)
Abstract

▪ Abstract  Phototransduction is the process by which a photon of light captured by a molecule of visual pigment generates an electrical response in a photoreceptor cell. Vertebrate rod phototransduction is one of the best-studied G protein signaling pathways. In this pathway the photoreceptor-specific G protein, transducin, mediates between the visual pigment, rhodopsin, and the effector enzyme, cGMP phosphodiesterase. This review focuses on two quantitative features of G protein signaling in phototransduction: signal amplification and response timing. We examine how the interplay between the mechanisms that contribute to amplification and those that govern termination of G protein activity determine the speed and the sensitivity of the cellular response to light.

Bibliography

Arshavsky, V. Y., Lamb, T. D., & Pugh, E. N. (2002). G Proteins and Phototransduction. Annual Review of Physiology, 64(1), 153–187.

Authors 3 University of Pennsylvania
  1. Vadim Y. Arshavsky (first) University of Pennsylvania
  2. Trevor D. Lamb (additional) University of Pennsylvania
  3. Edward N. Pugh (additional) University of Pennsylvania
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Dates
Type When
Created 23 years, 1 month ago (July 27, 2002, 7:41 a.m.)
Deposited 2 years, 4 months ago (April 23, 2023, 2:28 p.m.)
Indexed 2 days, 20 hours ago (Sept. 4, 2025, 9:10 a.m.)
Issued 23 years, 6 months ago (March 1, 2002)
Published 23 years, 6 months ago (March 1, 2002)
Published Print 23 years, 6 months ago (March 1, 2002)
Funders 0

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@article{Arshavsky_2002, title={G Proteins and Phototransduction}, volume={64}, ISSN={1545-1585}, url={http://dx.doi.org/10.1146/annurev.physiol.64.082701.102229}, DOI={10.1146/annurev.physiol.64.082701.102229}, number={1}, journal={Annual Review of Physiology}, publisher={Annual Reviews}, author={Arshavsky, Vadim Y. and Lamb, Trevor D. and Pugh, Edward N.}, year={2002}, month=mar, pages={153–187} }