Ligand-Gated Ion Channel Interactions with Cytoskeletal and Signaling Proteins
10.1146/annurev.physiol.62.1.755
Crossref journal-article
Annual Reviews
Annual Review of Physiology (22)
Abstract

▪ Abstract  In recent years, it has become apparent that ligand-gated ion channels (ionotropic receptors) in the neuronal plasma membrane interact via their cytoplasmic domains with a multitude of intracellular proteins. Different classes of ligand-gated channels associate with distinct sets of intracellular proteins, often through specialized scaffold proteins containing PDZ domains. These specific interactions link the receptor channel to the cortical cytoskeleton and to appropriate signal transduction pathways in the cell. Thus ionotropic receptors are components of extensive protein complexes that are likely involved in the subcellular targeting, cytoskeletal anchoring, and localized clustering of the receptors at specific sites on the neuronal surface. In addition to structural functions, receptor-associated proteins can play important roles as activity modulators or downstream effectors of ligand-gated channels.

Bibliography

Sheng, M., & Pak, D. T. S. (2000). Ligand-Gated Ion Channel Interactions with Cytoskeletal and Signaling Proteins. Annual Review of Physiology, 62(1), 755–778.

Authors 2
  1. Morgan Sheng (first)
  2. Daniel T. S. Pak (additional)
References 124 Referenced 283
  1. Colledge M, Froehner SC. 1998. Signals mediating ion channel clustering at the neuromuscular junction.Curr. Opin. Neurobiol.8:357–63 (10.1016/S0959-4388(98)80061-5)
  2. Kennedy MB. 1997. The postsynaptic density at glutamatergic synapses.Trends Neurosci.20:264–68 (10.1016/S0166-2236(96)01033-8)
  3. Ziff EB. 1997. Enlightening the postsynaptic density.Neuron19:1163–74 (10.1016/S0896-6273(00)80409-2)
  4. Rosenmund C, Westbrook GL. 1993. Calcium-induced actin depolymerization reduces NMDA channel activity.Neuron10:805–14 (10.1016/0896-6273(93)90197-Y)
  5. Paoletti P, Ascher P. 1994. Mechanosensitivity of NMDA receptors in cultured mouse central neurons.Neuron13:645– 55 (10.1016/0896-6273(94)90032-9)
  6. Dingledine R, Borges K, Bowie D, Traynelis SF. 1999. The glutamate receptor ion channels.Pharmacol. Rev.51:7–61
  7. Hollmann M, Heinemann S. 1994. Cloned glutamate receptors.Annu. Rev. Neurosci.17:31–108 (10.1146/annurev.ne.17.030194.000335)
  8. Kornau H-C, Schenker LT, Kennedy MB, Seeburg PH. 1995. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95.Science269:1737–40 (10.1126/science.7569905)
  9. Niethammer M, Kim E, Sheng M. 1996. Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases.J. Neurosci.16:2157–63 (10.1523/JNEUROSCI.16-07-02157.1996)
  10. Sheng M. 1996. PDZs and receptor/channel clustering: rounding up the latest suspects.Neuron17:575–78 (10.1016/S0896-6273(00)80190-7)
  11. Kornau HC, Seeburg PH, Kennedy MB. 1997. Interaction of ion channels and receptors with PDZ domain proteins.Curr. Opin. Neurobiol.7:368–73 (10.1016/S0959-4388(97)80064-5)
  12. O’Brien R, Lau L, Huganir R. 1998. Molecular mechanisms of glutamate receptor clustering at excitatory synapses.Curr. Opin. Neurobiol.8:364–69 (10.1016/S0959-4388(98)80062-7)
  13. Ponting CP, Phillips C, Davies KE, Blake DJ. 1997. PDZ domains: targeting signalling molecules to sub-membranous sites.BioEssays19:469–79 (10.1002/bies.950190606)
  14. Doyle DA, Lee A, Lewis J, Kim E, Sheng M, et al. 1996. Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ.Cell85:1067–76 (10.1016/S0092-8674(00)81307-0)
  15. Songyang Z, Fanning AS, Fu C, Xu J, Marfatia SM, et al. 1997. Recognition of unique carboxyl-terminal motifs by distinct PDZ domains.Science275:73–77 (10.1126/science.275.5296.73)
  16. Cowburn D. 1997. Peptide recognition by PTB and PDZ domains.Curr. Opin. Struct. Biol.7:835–38 (10.1016/S0959-440X(97)80155-8)
  17. Kim E, Niethammer M, Rothschild A, Jan YN, Sheng M. 1995. Clustering of Shaker-type K+channels by interaction with a family of membrane-associated guanylate kinases.Nature378:85–88 (10.1038/378085a0)
  18. Cho K-O, Hunt CA, Kennedy MB. 1992. The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein.Neuron9:929–42 (10.1016/0896-6273(92)90245-9)
  19. Kistner U, Wenzel BM, Veh RW, CasesLanghoff C, Garner AM, et al. 1993. SAP90, a rat presynaptic protein related to the product of theDrosophilatumor suppressor genedlg-A.J. Biol. Chem.268:4580–83 (10.1016/S0021-9258(18)53433-5)
  20. Brenman JE, Christopherson KS, Craven SE, McGee AW, Bredt DS. 1996. Cloning and characterization of postsynaptic density 93, a nitric oxide synthase interacting protein.J. Neurosci.16:7407–15 (10.1523/JNEUROSCI.16-23-07407.1996)
  21. Kim E, Cho K-O, Rothschild A, Sheng M. 1996. Heteromultimerization and NMDA receptor-clustering activity of chapsyn-110, a member of the PSD-95 family of proteins.Neuron17:103–13 (10.1016/S0896-6273(00)80284-6)
  22. Lue RA, Marfatia SM, Branton D, Chishti AH. 1994. Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1.Proc. Natl. Acad. Sci. USA91:9818–22 (10.1073/pnas.91.21.9818)
  23. Müller BM, Kistner U, Veh RW, CasesLanghoff C, Becker B, et al. 1995. Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and theDrosophiladiscs-large tumor suppressor protein.J. Neurosci.15:2354–66 (10.1523/JNEUROSCI.15-03-02354.1995)
  24. Müller BM, Kistner U, Kindler S, Chung WJ, Kuhlendahl S, et al. 1996. SAP102, a novel postsynaptic protein that interacts with the cytoplasmic tail of the NMDA receptor subunit NR2B.Neuron17:255– 65 (10.1016/S0896-6273(00)80157-9)
  25. Woods DF, Bryant PJ. 1991. The discslarge tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions.Cell66:451–64 (10.1016/0092-8674(81)90009-X)
  26. Guan B, Hartmann B, Kho Y-H, Gorczyca M, Budnik V. 1996. TheDrosophilatumor suppressor gene,dlg,is involved in structural plasticity at a glutamatergic synapse.Curr. Biol.6:695– 706 (10.1016/S0960-9822(09)00451-5)
  27. Tejedor FJ, Bokhari A, Rogero O, Gorczyca M, Zhang J, et al. 1997. Essential role fordlgin synaptic clustering of Shaker K+channels in vivo.J. Neurosci.17:152–59 (10.1523/JNEUROSCI.17-01-00152.1997)
  28. Thomas U, Kim E, Kuhlendahl S, Ho Koh Y, Gundelfinger ED, et al. 1997. Synaptic clustering of the cell adhesion molecule fasciclin II by discs-large and its role in the regulation of presynaptic structure.Neuron19:787–99 (10.1016/S0896-6273(00)80961-7)
  29. Zito K, Fetter RD, Goodman CS, Isacoff EY. 1997. Synaptic clustering of fasciclin II and shaker: essential targeting sequences and role of dlg.Neuron19:1007–16 (10.1016/S0896-6273(00)80393-1)
  30. Tsunoda S, Sierralta J, Sun Y, Bodner R, Suzuki E, et al. 1997. A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade.Nature388:243–49 (10.1038/40805)
  31. Montell C. 1998. TRP trapped in fly signaling web.Curr. Opin. Neurobiol.8:389–97 (10.1016/S0959-4388(98)80066-4)
  32. Bredt DS. 1998. Sorting out genes that regulate epithelial and neuronal polarity.Cell94:691–94 (10.1016/S0092-8674(00)81727-4)
  33. Migaud M, Charlesworth P, Dempster M, Webster LC, Watabe AM, et al. 1998. Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein.Nature396:433–39 (10.1038/24790)
  34. Mori H, Manabe T, Watanabe M, Sath Y, Suzuki N, et al. 1998. Role of the carboxy-terminal region of the GluR epsilon2 subunit in synaptic localization of the NMDA receptor channel.Neuron21:571–80 (10.1016/S0896-6273(00)80567-X)
  35. Sprengel R, Suchanek B, Amico C, Brusa R, Burnasheve N, et al. 1998. Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo.Cell92:279–89 (10.1016/S0092-8674(00)80921-6)
  36. Leonard AS, Lim IA, Hemsworth DE, Horne MC, Hell JW. 1999. Calcium/calmodulin-dependent protein kinase II is associated with theN-methyl-D-aspartate receptor.Proc. Natl. Acad. Sci. USA96:3239–44 (10.1073/pnas.96.6.3239)
  37. Strack S, Colbran RJ. 1998. Autophosphorylation-dependent targeting of calcium/calmodulin-dependent protein kinase II by the NR2B subunit of theNmethyl-D-aspartate receptor.J. Biol. Chem.273:20689–92 (10.1074/jbc.273.33.20689)
  38. Shen K, Meyer T. 1999. Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation.Science284:162– 66 (10.1126/science.284.5411.162)
  39. Craven S, Bredt D. 1998. PDZ proteins organize synaptic signaling pathways.Cell93:495–98 (10.1016/S0092-8674(00)81179-4)
  40. Brenman JE, Chao DS, Gee SH, McGee AW, Craven SE, et al. 1996. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and α1syntrophin mediated by PDZ domains.Cell84:757–67 (10.1016/S0092-8674(00)81053-3)
  41. Dawson VL, Dawson TM, London ED, Bredt DS, Snyder SH. 1991. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.Proc. Natl. Acad. Sci. USA88:6368–71 (10.1073/pnas.88.14.6368)
  42. Holscher C. 1997. Nitric oxide, the enigmatic neuronal messenger: its role in synaptic plasticity.Trends Neurosci.20:298–303 (10.1016/S0166-2236(97)01065-5)
  43. Kim JH, Liao D, Lau LF, Huganir RL. 1998. SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family.Neuron20:683–91 (10.1016/S0896-6273(00)81008-9)
  44. Chen HJ, Rojas-Soto M, Oguni A, Kennedy MB. 1998. A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II.Neuron20:895– 904 (10.1016/S0896-6273(00)80471-7)
  45. Yun H, Gonzalez-Zulueta M, Dawson V, Dawson T. 1998. Nitric oxide mediatesN-methyl-D-aspartate receptor-induced activation of p21ras.Proc. Natl. Acad. Sci.95:5773–78 (10.1073/pnas.95.10.5773)
  46. Zhang W, Vazquez L, Apperson M, Kennedy MB. 1999. Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus.J. Neurosci.19:96–108 (10.1523/JNEUROSCI.19-01-00096.1999)
  47. Furuyashiki T, Fujisawa K, Fujita A, Madaule P, Uchino S, et al. 1999. Citron, a Rho-target, interacts with PSD-95/ SAP-90 at glutamatergic synapses in the thalamus.J. Neurosci.19:109–18 (10.1523/JNEUROSCI.19-01-00109.1999)
  48. Wang YT, Salter MW. 1994. Regulation of NMDA receptors by tyrosine kinases and phosphatases.Nature369:233–35 (10.1038/369233a0)
  49. Köhr G, Seeburg PH. 1996. Subtypespecific regulation of recombinant rat and mouse NMDA receptor-channels by protein tyrosine kinase of thesrcfamily.J. Physiol.492:445–52 (10.1113/jphysiol.1996.sp021320)
  50. Lu YM, Roder JC, Davidow J, Salter MW. 1998. Src activation in the induction of long-term potentiation in CA1 hippocampal neurons.Science279:1363–67 (10.1126/science.279.5355.1363)
  51. Rostas JA, Brent VA, Voss K, Errington ML, Bliss TV, et al. 1996. Enhanced tyrosine phosphorylation of the 2B subunit of theN-methyl-D-aspartate receptor in long-term potentiation.Proc. Natl. Acad. Sci. USA93:10452–56 (10.1073/pnas.93.19.10452)
  52. Rosenblum K, Dudai Y, Richter-Levin G. 1996. Long-term potentiation increases tyrosine phosphorylation of theNmethyl-D-aspartate receptor subunit 2B in rat dentate gyrus in vivo.Proc. Natl. Acad. Sci. USA93:10457–60 (10.1073/pnas.93.19.10457)
  53. Tezuka T, Umemori H, Akiyama T, Nakanishi S, Yamamoto T. 1999. PSD-95 promotes fyn-mediated tyrosine phosphorylation of theN-methyl-D-aspartate receptor subunit NR2A.Proc. Natl. Acad. Sci. USA96:435–40 (10.1073/pnas.96.2.435)
  54. Yu X, Askalan R, Keil G, Salter M. 1997. NMDA channel regulation by channelassociated protein tyrosine kinase Src.Science275:674–78 (10.1126/science.275.5300.674)
  55. Kuhlendahl S, Spangenberg O, Konrad M, Kim E, Garner C. 1998. Functional analysis of the guanylate kinase-like domain in the synapse-associated protein SAP97.Eur. J. Biochem.252:305–13 (10.1046/j.1432-1327.1998.2520305.x)
  56. Kim E, Naisbitt S, Hsueh Y-P, Rao A, Rothschild A, et al. 1997. GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules.J. Cell Biol.136:669– 78 (10.1083/jcb.136.3.669)
  57. Naisbitt S, Kim E, Weinberg RJ, Rao A, Yang F-C, et al. 1997. Characterization of guanylate kinase-associated protein, a postsynaptic density protein at excitatory synapses that interacts directly with postsynaptic density-95/synapse-associated protein 90.J. Neurosci.17:5687–96 (10.1523/JNEUROSCI.17-15-05687.1997)
  58. Takeuchi M, Hata Y, Hirao K, Toyoda A, Irie M, et al. 1997. SAPAPs, a family of PSD-95/SAP90-associated proteins localized at postsynaptic density.J. Biol. Chem.272:11943–51 (10.1074/jbc.272.18.11943)
  59. Satoh K, Yanai H, Senda T, Kohu K, Nakamura T, et al. 1997. DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD95.Genes Cells2:415–24 (10.1046/j.1365-2443.1997.1310329.x)
  60. Deguchi M, Hata Y, Takeuchi M, Ide N, Hirao K, et al. 1998. BEGAIN (brainenriched guanylate kinase-associated protein), a novel neuronal PSD-95/ SAP90-binding protein.J. Biol. Chem.273:26269–72 (10.1074/jbc.273.41.26269)
  61. Brenman JE, Topinka RJ, Cooper EC, McGee AW, Rosen J, et al. 1998. Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A.J. Neurosci.18:8805–13 (10.1523/JNEUROSCI.18-21-08805.1998)
  62. Xu X-ZS, Choudhury A, Li X, Montell C. 1998. Coordination of an array of signaling proteins through homo- and heteromeric interactions between PDZ domains and target proteins.J. Cell Biol.142:545–55 (10.1083/jcb.142.2.545)
  63. Matsumine A, Ogai A, Senda T, Okumura N, Satoh K, et al. 1996. Binding of APC to the human homolog of theDrosophiladiscs large tumor suppressor protein.Science272:1020–23 (10.1126/science.272.5264.1020)
  64. Pawson T. 1995. Protein modules and signalling networks.Nature373:573–80 (10.1038/373573a0)
  65. Garcia EP, Mehta S, Blair LA, Wells DG, Shang J, et al. 1998. SAP90 binds and clusters kainate receptors causing incomplete desensitization.Neuron21:727–39 (10.1016/S0896-6273(00)80590-5)
  66. Marfatia SM, Cabral JH, Lin L, Hough C, Bryant PJ, et al. 1996. Modular organization of the PDZ domains in the human discs-large protein suggests a mechanism for coupling PDZ domainbinding proteins to ATP and the membrane cytoskeleton.J. Cell Biol.135:753–66 (10.1083/jcb.135.3.753)
  67. Lue RA, Brandin E, Chan EP, Branton D. 1996. Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1–2 conformational unit and an alternatively spliced domain.J. Cell Biol.135:1125–37 (10.1083/jcb.135.4.1125)
  68. Cohen AR, Woods DF, Marfatia SM, Walther Z, Chishti AH, et al. 1998. Human Cask/Lin-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells.J. Cell Biol.142:129–38 (10.1083/jcb.142.1.129)
  69. Kelly PT, Cotman CW. 1978. Synaptic proteins. Characterization of tubulin and actin and identification of a distinct postsynaptic density polypeptide.J. Cell Biol.79:173–83 (10.1083/jcb.79.1.173)
  70. Caceres A, Binder LI, Payne MR, Bender P, Rebhun L, et al. 1984. Differential subcellular localization of tubulin and the microtubule-associated protein MAP2 in brain tissue as revealed by immunocytochemistry with monoclonal hybridoma antibodies.J. Neurosci.4:394–410 (10.1523/JNEUROSCI.04-02-00394.1984)
  71. Walsh MJ, Kuruc N. 1992. The postsynaptic density: constituent and associated proteins characterized by electrophoresis, immunoblotting, and peptide sequencing.J. Neurochem.59:667–78 (10.1111/j.1471-4159.1992.tb09421.x)
  72. Niethammer M, Valtschanoff JG, Kapoor TM, Allison DW, Weinberg RJ, et al. 1998. CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90.Neuron20:693–707 (10.1016/S0896-6273(00)81009-0)
  73. van Rossum D, Kuhse J, Betz H. 1999. Dynamic interaction between soluble tubulin and C-terminal domains ofNmethyl-N-methyl-D-aspartate receptor subunits.J. Neurochem.72:962–73 (10.1046/j.1471-4159.1999.0720962.x)
  74. Lai SL, Ling SC, Kuo LH, Shu YC, Chow WY, et al. 1998. Characterization of granular particles isolated from postsynaptic densities.J. Neurochem.71:1694–701 (10.1046/j.1471-4159.1998.71041694.x)
  75. Harris KM, Kater SB. 1994. Dendritic spines: cellular specializations imparting both stability and flexibility to synaptic function.Annu. Rev. Neurosci.17:341– 71 (10.1146/annurev.ne.17.030194.002013)
  76. Hsueh Y-P, Kim E, Sheng M. 1997. Disulfide-linked head-to-head multimerization in the mechanism of ion channel clustering by PSD-95.Neuron18:803– 14 (10.1016/S0896-6273(00)80319-0)
  77. Hsueh Y-P, Sheng M. 1999. Requirement of N-terminal cysteines of PSD-95 for PSD-95 multimerization and ternary complex formation, but not for binding to potassium channel Kv1.4.J. Biol. Chem.174:532–36 (10.1074/jbc.274.1.532)
  78. Topinka JR, Bredt DS. 1998. N-terminal palmitoylation of PSD-95 regulates association with cell membranes and interaction with K+channel Kv1.4.Neuron20:125–34 (10.1016/S0896-6273(00)80440-7)
  79. Craven SE, El-Husseini AE, Bredt DS. 1999. Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifs.Neuron22:497–509 (10.1016/S0896-6273(00)80705-9)
  80. Wyszynski M, Lin J, Rao A, Nigh E, Beggs AH, et al. 1997. Competitive binding of alpha-actinin and calmodulin to the NMDA receptor.Nature385:439– 42 (10.1038/385439a0)
  81. Wyszynski M, Kharazia V, Shanghvi R, Rao A, Beggs AH, et al. 1998. Differential regional expression and ultrastructural localization of α-actinin-2, a putative NMDA receptor-anchoring protein, in rat brain.J. Neurosci.18:1383– 92 (10.1523/JNEUROSCI.18-04-01383.1998)
  82. Ehlers MD, Zhang S, Bernhardt JP, Huganir RL. 1996. Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit.Cell84:745–55 (10.1016/S0092-8674(00)81052-1)
  83. Zhang S, Ehlers MD, Bernhardt JP, Su CT, Huganir RL. 1998. Calmodulin mediates calcium-dependent inactivation ofN-methyl-D-aspartate receptors.Neuron21:443–53 (10.1016/S0896-6273(00)80553-X)
  84. Krupp JJ, Vissel B, Thomas CG, Heinemann SF, Westbrook GL. 1999. Interactions of calmodulin and alpha-actinin with the NR1 subunit modulate Ca2+dependent inactivation of NMDA receptors.J. Neurosci.19:1165–78 (10.1523/JNEUROSCI.19-04-01165.1999)
  85. Levitan I. 1999. It is calmodulin after all! Mediator of the calcium modulation of multiple ion channels.Neuron22:645– 48 (10.1016/S0896-6273(00)80722-9)
  86. Ehlers MD, Tingley WG, Huganir RL. 1995. Regulated subcellular distribution of the NR1 subunit of the NMDA receptor.Science269:1734–37 (10.1126/science.7569904)
  87. Lin JW, Wyszynski M, Madhavan R, Sealock R, Kim JU, et al. 1998. Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1.J. Neurosci.18:2017–27 (10.1523/JNEUROSCI.18-06-02017.1998)
  88. Ehlers MD, Fung ET, O’Brien RJ, Huganir RL. 1998. Splice variantspecific interaction of the NMDA receptor subunit NR1 with neuronal intermediate filaments.J. Neurosci.18:720–30 (10.1523/JNEUROSCI.18-02-00720.1998)
  89. Westphal RS, Tavalin SJ, Lin JW, Alto NM, Iain DC, et al. 1999. Regulation of NMDA receptors by an associated phosphatase kinase signaling complex.Science285(5424):93–95 (10.1126/science.285.5424.93)
  90. Hirao K, Hata Y, Ide N, Takeuchi M, Irie M, et al. 1998. A novel multiple PDZ domain-containing molecule interacting withN-methyl-D-aspartate receptors and neuronal cell adhesion proteins.J. Biol. Chem.273:21105–10 (10.1074/jbc.273.33.21105)
  91. Wechsler A, Teichberg V. 1998. Brain spectrin binding to the NMDA receptor is regulated by phosphorylation, calcium and calmodulin.EMBO J.17(14):3931– 39 (10.1093/emboj/17.14.3931)
  92. Wenthold RJ, Petralia RS, Blahos JI, Niedzielski AS. 1996. Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons.J. Neurosci.16:1982–89 (10.1523/JNEUROSCI.16-06-01982.1996)
  93. Dong H, O’Brien RJ, Fung ET, Lanahan AA, Worley PF, et al. 1997. GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors.Nature386:279–84 (10.1038/386279a0)
  94. Wyszynski M, Kim E, Yang F-C, Sheng M. 1998. Biochemical and immunocytochemical characterization of GRIP, a putative AMPA receptor anchoring protein, in rat brain.Neuropharm.37:1335– 44 (10.1016/S0028-3908(98)00120-8)
  95. Srivastava S, Osten P, Vilim F, Khatri L, Inman G, et al. 1998. Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP.Neuron21:581–91 (10.1016/S0896-6273(00)80568-1)
  96. Bruckner K, Pablo Labrador J, Scheiffele P, Herb A, Seeburg PH, et al. 1999. EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains.Neuron22:511–24 (10.1016/S0896-6273(00)80706-0)
  97. Wyszynski M, Valtschanoff JG, Naisbitt S, Dunah AW, Kim E, et al. 1999. Association of AMPA receptors with a subset of glutmate receptor-interacting protein in vivo.J. Neurosci.19:6528–37 (10.1523/JNEUROSCI.19-15-06528.1999)
  98. Dong H, Zhang P, Song I, Petralia RS, Liao D, et al. 1999. Characterization of the glutamate receptor-interacting proteins GRIP1 and GRIP2.J. Neurosci.19:6930–41 (10.1523/JNEUROSCI.19-16-06930.1999)
  99. Malenka RC, Nicoll RA. 1997. Silent synapses speak up.Neuron19:473–76 (10.1016/S0896-6273(00)80362-1)
  100. Torres R, Firestein BL, Dong H, Staudinger J, Olson EN, et al. 1998. PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands.Neuron21:1453–63 (10.1016/S0896-6273(00)80663-7)
  101. Flanagan JG, Vanderhaeghen P. 1998. The ephrins and Eph receptors in neural development.Annu. Rev. Neurosci.21:309–45 (10.1146/annurev.neuro.21.1.309)
  102. Serra-Pages C, Medley QG, Tang M, Hart A, Streuli M. 1998. Liprins, a family of LAR transmembrane proteintyrosine phosphatase-interacting proteins.J. Biol. Chem.273:15611–20 (10.1074/jbc.273.25.15611)
  103. Van Vactor D. 1998. Protein tyrosine phosphatases in the developing nervous system.Curr. Opin. Cell Biol.10:174–81 (10.1016/S0955-0674(98)80139-7)
  104. Xia J, Zhang X, Staudinger J, Huganir RL. 1999. Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1.Neuron22:179–87 (10.1016/S0896-6273(00)80689-3)
  105. Staudinger J, Zhou J, Burgess R, Elledge SJ, Olson EN. 1995. PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system.J. Cell Biol.128:263–71 (10.1083/jcb.128.3.263)
  106. Leonard AS, Davare MA, Horne MC, Garner CC, Hell JW. 1998. SAP97 is associated with the alpha-amino-3hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit.J. Biol. Chem.273:19518–24 (10.1074/jbc.273.31.19518)
  107. Nishimune A, Isaac JT, Molnar E, Noel J, Nash SR, et al. 1998. NSF binding to GluR2 regulates synaptic transmission.Neuron21:87–97 (10.1016/S0896-6273(00)80517-6)
  108. Osten P, Srivastava S, Inman GJ, Vilim FS, Khatri L, et al. 1998. The AMPA receptor GluR2 C terminus can mediate a reversible, ATP- dependent interaction with NSF and alpha- and beta-SNAPs.Neuron21:99–110 (10.1016/S0896-6273(00)80518-8)
  109. Song I, Kamboj S, Xia J, Dong H, Liao D, et al. 1998. Interaction of theN-ethylmaleimide-sensitive factor with AMPA receptors.Neuron21:393–400 (10.1016/S0896-6273(00)80548-6)
  110. Lin JW, Sheng M. 1998. NSF and AMPA receptors get physical.Neuron21:267– 70 (10.1016/S0896-6273(00)80534-6)
  111. Hayashi T, Umemori H, Mishina M, Yamamoto T. 1999. The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn.Nature397:72–76 (10.1038/16269)
  112. Wang Y, Small DL, Stanimirovic DB, Morley P, Durkin JP. 1997. AMPA receptor-mediated regulation of a Gi-protein in cortical neurons.Nature389:502–4 (10.1038/39062)
  113. Zuo J, De Jager PL, Takahashi KA, Jiang W, Linden DJ, et al. 1997. Neurodegeneration in Lurcher mice caused by mutation in δ2 glutamate receptor gene.Nature388:769–73 (10.1038/42009)
  114. Kashiwabuchi N, Ikeda K, Araki K, Hirano T, Shibuki K, et al. 1995. Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluRδ2 mutant mice.Cell81:245–52 (10.1016/0092-8674(95)90334-8)
  115. Roche KW, Ly CD, Petralia RS, Wang YX, McGee AW, et al. 1999. Postsynaptic density-93 interacts with the δ2 glutamate receptor subunit at parallel fiber synapses.J. Neurosci.In press (10.1523/JNEUROSCI.19-10-03926.1999)
  116. Craig AM, Blackstone CD, Huganir RL, Banker G. 1994. Selective clustering of glutamate and γ-aminobutyric acid receptors opposite terminals releasing the corresponding neurotransmitters.Proc. Natl. Acad. Sci.USA91:12373–77 (10.1073/pnas.91.26.12373)
  117. Wang H, Bedford FK, Brandon NJ, Moss SJ, Olsen RW. 1999. GABAA-receptorassociated protein links GABAAreceptors and the cytoskeleton.Nature397:69–72 (10.1038/16264)
  118. Hanley JG, Koulen P, Bedford F, Gordon-Weeks PR, Moss SJ. 1999. The protein MAP-1B links GABACreceptors to the cytoskeleton at retinal synapses.Nature397:66–69 (10.1038/16258)
  119. Fujii T, Watanabe M, Ogoma Y, Kondo Y, Arai T. 1993. Microtubule-associated proteins, MAP1A and MAP1B, interact with F-actin in vitro.J. Biochem. (Tokyo)114:827–29 (10.1093/oxfordjournals.jbchem.a124263)
  120. Kuhse J, Betz H, Kirsch J. 1995. The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex.Curr. Opin. Neurobiol.5:318– 23 (10.1016/0959-4388(95)80044-1)
  121. Meyer G, Kirsch J, Betz H, Langosch D. 1995. Identification of a gephyrin binding motif on the glycine receptor β subunit.Neuron15:563–72 (10.1016/0896-6273(95)90145-0)
  122. Feng G, Tintrup H, Kirsch J, Nichol M, Kuhse J, et al. 1998. Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity.Science282:1321–24 (10.1126/science.282.5392.1321)
  123. Essrich C, Lopez M, Benson JA, Fritschy J-M, Luscher B. 1998. Postsynaptic clustering of major GABAAreceptor subtypes requires the γ2subunit and gephyrin.Nat. Neurosci.1:563–71 (10.1038/2798)
  124. Nusser Z, Sieghart W, Somogyi P. 1998. Segregation of different GABAAreceptors to synaptic and extrasynaptic membranes of cerebellar granule cells.J. Neurosci.18:1693–703 (10.1523/JNEUROSCI.18-05-01693.1998)
Dates
Type When
Created 23 years, 1 month ago (July 27, 2002, 7:46 a.m.)
Deposited 3 years, 10 months ago (Oct. 16, 2021, 4:51 p.m.)
Indexed 4 weeks, 1 day ago (Aug. 5, 2025, 9:07 a.m.)
Issued 25 years, 6 months ago (March 1, 2000)
Published 25 years, 6 months ago (March 1, 2000)
Published Print 25 years, 6 months ago (March 1, 2000)
Funders 0

None

@article{Sheng_2000, title={Ligand-Gated Ion Channel Interactions with Cytoskeletal and Signaling Proteins}, volume={62}, ISSN={1545-1585}, url={http://dx.doi.org/10.1146/annurev.physiol.62.1.755}, DOI={10.1146/annurev.physiol.62.1.755}, number={1}, journal={Annual Review of Physiology}, publisher={Annual Reviews}, author={Sheng, Morgan and Pak, Daniel T. S.}, year={2000}, month=mar, pages={755–778} }