DOI: 10.1146/annurev.physiol.59.1.527. SPATIAL RELATIONSHIPS IN EARLY SIGNALING EVENTS OF FLOW-MEDIATED ENDOTHELIAL MECHANOTRANSDUCTION [Penn]

SPATIAL RELATIONSHIPS IN EARLY SIGNALING EVENTS OF FLOW-MEDIATED ENDOTHELIAL MECHANOTRANSDUCTION

10.1146/annurev.physiol.59.1.527

Crossref journal-article

Annual Reviews

Annual Review of Physiology (22)

Abstract

▪ Abstract Blood flow interactions with the vascular endothelium represent a specialized example of mechanical regulation of cell function that has important physiological and pathological cardiovascular consequences. The endothelial monolayer in vivo acts as a signal transduction interface for forces associated with flowing blood (hemodynamic forces) in the acute regulation of artery tone and chronic structural remodeling of arteries, including the pathology of atherosclerosis. Mechanisms related to spatial relationships at the cell surfaces and throughout the cell that influence flow-mediated endothelial mechanotransduction are discussed. In particular, flow-mediated ion channel activation and cytoskeletal dynamics are considered in relation to topographic analyses of the luminal and abluminal surfaces of living endothelial cells.

Bibliography

Davies, P. F., Barbee, K. A., Volin, M. V., Robotewskyj, A., Chen, J., Joseph, L., Griem, M. L., Wernick, M. N., Jacobs, E., Polacek, D. C., DePaola, N., & Barakat, A. I. (1997). SPATIAL RELATIONSHIPS IN EARLY SIGNALING EVENTS OF FLOW-MEDIATED ENDOTHELIAL MECHANOTRANSDUCTION. Annual Review of Physiology, 59(1), 527â549.

Authors 12

Peter F. Davies (first)
Kenneth A. Barbee (additional)
Michael V. Volin (additional)
Andre Robotewskyj (additional)
Jai Chen (additional)
Loren Joseph (additional)
Melvin L. Griem (additional)
Miles N. Wernick (additional)
Elizabeth Jacobs (additional)
Denise C. Polacek (additional)
Natacha DePaola (additional)
Abdul I. Barakat (additional)

References 88 Referenced 266

10.1096/fasebj.3.12.2477294
10.1007/BF02368159
10.1006/bbrc.1993.1108
10.1161/01.RES.78.5.750
10.1161/01.RES.74.1.163
{'key': 'b6', 'first-page': '1765', 'volume': '268', 'author': 'Barbee KA', 'year': '1995', 'journal-title': 'Am. J. Physiol.'} / Am. J. Physiol. by Barbee KA (1995)
10.1016/0021-9290(95)00092-5
10.1016/0014-5793(92)81292-T
10.1159/000158963
10.1242/jcs.1987.Supplement_8.13
{'key': 'b11', 'first-page': '18', 'volume': '4', 'author': 'Burridge K', 'year': '1986', 'journal-title': 'Cancer Res.'} / Cancer Res. by Burridge K (1986)
10.1146/annurev.cb.04.110188.002415
10.1038/2231159a0
10.1126/science.7268440
{'key': 'b15', 'author': 'Chen J', 'year': '1996', 'journal-title': 'Proc. IASTED Signal Image Process.'} / Proc. IASTED Signal Image Process. by Chen J (1996)
10.1242/jcs.104.4.1145 / J. Cell Sci. by Coan DE (1993)
10.1172/JCI115481
{'key': 'b18', 'first-page': '1', 'volume': '88', 'author': 'Corson MA', 'year': '1993', 'journal-title': 'Circulation'} / Circulation by Corson MA (1993)
10.1152/physrev.1995.75.3.519
10.1016/0021-9290(95)00102-6
10.1172/JCI116503
10.1172/JCI117197
10.1161/01.RES.72.2.239
10.1007/978-1-4684-7508-1_2
10.1115/1.3138276
10.1002/jcp.1041430222
{'key': 'b27', 'first-page': 'H653', 'volume': '264', 'author': 'Falcone JC', 'year': '1993', 'journal-title': 'Am. J. Physiol.'} / Am. J. Physiol. by Falcone JC (1993)
Flitney FW, Goldman RD, Skalli O, Mercurius K, Davies PF. 1996. Dynamic properties of intermediate filaments in cultured endothelial cells: effects of controlled fluid shear stress. InThe Biology of Nitric Oxide, ed. S Moncada, J Stamler, S Gross, EA Higgs, p. 251. London: Portland
10.1073/pnas.88.5.1788
10.1126/science.3883488
10.1038/307648a0
Fry DL. 1973. Atherogenesis: initiating factors. InCiba Found. Symp. 12, pp. 96–118. London: Ciba Found.
10.1115/1.2895465
10.1152/ajpcell.1992.262.6.C1411
10.1055/s-0038-1642664 / Thromb. Hemost. by Grabowski EF (1995)
10.1242/jcs.29.1.197 / J. Cell Sci. by Heath JP (1978)
10.1097/00041433-199508000-00002
10.1083/jcb.105.1.291
10.1161/01.HYP.21.1.112
10.1038/362031a0
10.1152/ajpcell.1994.266.3.C590 / Am. J. Physiol. by Hutcheson IR (1994)
10.1016/0092-8674(92)90115-S
10.1016/0955-0674(91)90058-7
Ingber DE, Jamieson JD. 1985. Cells as tensegrity structures: architectural regulation of histodifferentiation by physical forces transduced over basement membrane. InGene Expression During Normal and Malignant Differentiation, ed. LC Andersson, CG Gahmberg, P Ekblom, pp. 13–32. Orlando FL: Academic
10.1242/jcs.42.1.81 / J. Cell Sci. by Izzard CS (1980)
10.1007/BF00374386
{'key': 'b47', 'first-page': 'H962', 'volume': '259', 'author': 'Kaiser L', 'year': '1989', 'journal-title': 'Am. J. Physiol.'} / Am. J. Physiol. by Kaiser L (1989)
10.1161/01.RES.72.6.1276
10.1006/bbrc.1994.1794
10.1111/j.1476-5381.1990.tb12735.x
10.1007/BF00392067
10.1038/355356a0
10.1242/jcs.109.4.713 / J. Cell Sci. by Malek AM (1996)
10.1016/S0021-9258(19)85359-0 / J. Biol. Chem. by Marsden PA (1993)
10.1097/00002480-198907000-00036
10.1096/fasebj.9.5.7534736 / FASEB J. by McKinsey J (1995)
10.1093/cvr/23.9.741
10.1172/JCI117410
10.1073/pnas.85.6.1841
10.1115/1.3138275
10.1172/JCI116092
10.1161/01.CIR.88.1.193
10.1006/bbrc.1993.1624
10.1161/01.RES.73.3.492
10.1038/331168a0
{'key': 'b66', 'first-page': '1', 'volume': '88', 'author': 'Perry PB', 'year': '1993', 'journal-title': 'Circulation'} / Circulation by Perry PB (1993)
10.1006/bbrc.1993.2218
10.1073/pnas.90.10.4591
10.1096/fasebj.9.10.7615157
10.1353/pbm.1970.0054
10.1016/0006-291X(92)91550-A
{'key': 'b72', 'first-page': '141', 'volume': '16', 'author': 'Sachs F', 'year': '1988', 'journal-title': 'CRC Crit. Rev. Biomed. Eng.'} / CRC Crit. Rev. Biomed. Eng. by Sachs F (1988)
10.1115/1.2891388
10.1159/000159039
10.1161/01.RES.74.2.349
10.1152/ajpcell.1992.262.2.C384
10.1073/pnas.91.11.4678
10.1016/0021-9290(95)00093-3
10.1016/S0022-5320(66)80127-2
10.1007/BF00586515
10.1161/01.RES.77.5.869
10.1152/ajpcell.1995.269.6.C1371
Virchow R. 1860. InCellular Pathology as Based Upon Physiological and Pathological Histology. Transl. F Clance. London: Churchill (From German)
10.1161/01.ATV.15.1.2
10.1126/science.7684161
{'key': 'b86', 'first-page': '639', 'volume': '53', 'author': 'Wechezak AR', 'year': '1985', 'journal-title': 'Lab. Invest.'} / Lab. Invest. by Wechezak AR (1985)
10.1067/mva.1987.avs0050413
10.1161/01.ATV.14.4.636

Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 7:46 a.m.)
Deposited	3 years, 10 months ago (Oct. 16, 2021, 8:03 p.m.)
Indexed	3 weeks, 6 days ago (Aug. 2, 2025, 12:41 a.m.)
Issued	27 years, 10 months ago (Oct. 1, 1997)
Published	27 years, 10 months ago (Oct. 1, 1997)
Published Print	27 years, 10 months ago (Oct. 1, 1997)

Funders 0

None

BibTeX

@article{Davies_1997, title={SPATIAL RELATIONSHIPS IN EARLY SIGNALING EVENTS OF FLOW-MEDIATED ENDOTHELIAL MECHANOTRANSDUCTION}, volume={59}, ISSN={1545-1585}, url={http://dx.doi.org/10.1146/annurev.physiol.59.1.527}, DOI={10.1146/annurev.physiol.59.1.527}, number={1}, journal={Annual Review of Physiology}, publisher={Annual Reviews}, author={Davies, Peter F. and Barbee, Kenneth A. and Volin, Michael V. and Robotewskyj, Andre and Chen, Jai and Joseph, Loren and Griem, Melvin L. and Wernick, Miles N. and Jacobs, Elizabeth and Polacek, Denise C. and DePaola, Natacha and Barakat, Abdul I.}, year={1997}, month=oct, pages={527–549} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        2
      ]
    ],
    "date-time": "2025-08-02T04:41:10Z",
    "timestamp": 1754109670305
  },
  "reference-count": 88,
  "publisher": "Annual Reviews",
  "issue": "1",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1997,
        10
      ]
    ]
  },
  "abstract": "<jats:p> \u25aa Abstract\u2002 Blood flow interactions with the vascular endothelium represent a specialized example of mechanical regulation of cell function that has important physiological and pathological cardiovascular consequences. The endothelial monolayer in vivo acts as a signal transduction interface for forces associated with flowing blood (hemodynamic forces) in the acute regulation of artery tone and chronic structural remodeling of arteries, including the pathology of atherosclerosis. Mechanisms related to spatial relationships at the cell surfaces and throughout the cell that influence flow-mediated endothelial mechanotransduction are discussed. In particular, flow-mediated ion channel activation and cytoskeletal dynamics are considered in relation to topographic analyses of the luminal and abluminal surfaces of living endothelial cells. </jats:p>",
  "DOI": "10.1146/annurev.physiol.59.1.527",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        27
      ]
    ],
    "date-time": "2002-07-27T11:46:15Z",
    "timestamp": 1027770375000
  },
  "page": "527-549",
  "source": "Crossref",
  "is-referenced-by-count": 266,
  "title": "SPATIAL RELATIONSHIPS IN EARLY SIGNALING EVENTS OF FLOW-MEDIATED ENDOTHELIAL MECHANOTRANSDUCTION",
  "prefix": "10.1146",
  "volume": "59",
  "author": [
    {
      "given": "Peter F.",
      "family": "Davies",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104;"
        },
        {
          "name": "Department of Neurosurgery, Hahnemann Medical College of Pennsylvania, Philadelphia, Pennsylvania 19102;"
        },
        {
          "name": "Departments of 3Pathology, 4Radiology, and 5Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois 60637;"
        },
        {
          "name": "Department of Electrical and Computer Engineering, Illinois Institute of Technology, Chicago, Illinois 60616;"
        },
        {
          "name": "Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226;"
        }
      ]
    },
    {
      "given": "Kenneth A.",
      "family": "Barbee",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104;"
        },
        {
          "name": "Department of Neurosurgery, Hahnemann Medical College of Pennsylvania, Philadelphia, Pennsylvania 19102;"
        },
        {
          "name": "Departments of 3Pathology, 4Radiology, and 5Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois 60637;"
        },
        {
          "name": "Department of Electrical and Computer Engineering, Illinois Institute of Technology, Chicago, Illinois 60616;"
        },
        {
          "name": "Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226;"
        }
      ]
    },
    {
      "given": "Michael V.",
      "family": "Volin",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104;"
        },
        {
          "name": "Department of Neurosurgery, Hahnemann Medical College of Pennsylvania, Philadelphia, Pennsylvania 19102;"
        },
        {
          "name": "Departments of 3Pathology, 4Radiology, and 5Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois 60637;"
        },
        {
          "name": "Department of Electrical and Computer Engineering, Illinois Institute of Technology, Chicago, Illinois 60616;"
        },
        {
          "name": "Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226;"
        }
      ]
    },
    {
      "given": "Andre",
      "family": "Robotewskyj",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104;"
        },
        {
          "name": "Department of Neurosurgery, Hahnemann Medical College of Pennsylvania, Philadelphia, Pennsylvania 19102;"
        },
        {
          "name": "Departments of 3Pathology, 4Radiology, and 5Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois 60637;"
        },
        {
          "name": "Department of Electrical and Computer Engineering, Illinois Institute of Technology, Chicago, Illinois 60616;"
        },
        {
          "name": "Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226;"
        }
      ]
    },
    {
      "given": "Jai",
      "family": "Chen",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104;"
        },
        {
          "name": "Department of Neurosurgery, Hahnemann Medical College of Pennsylvania, Philadelphia, Pennsylvania 19102;"
        },
        {
          "name": "Departments of 3Pathology, 4Radiology, and 5Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois 60637;"
        },
        {
          "name": "Department of Electrical and Computer Engineering, Illinois Institute of Technology, Chicago, Illinois 60616;"
        },
        {
          "name": "Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226;"
        }
      ]
    },
    {
      "given": "Loren",
      "family": "Joseph",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104;"
        },
        {
          "name": "Department of Neurosurgery, Hahnemann Medical College of Pennsylvania, Philadelphia, Pennsylvania 19102;"
        },
        {
          "name": "Departments of 3Pathology, 4Radiology, and 5Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois 60637;"
        },
        {
          "name": "Department of Electrical and Computer Engineering, Illinois Institute of Technology, Chicago, Illinois 60616;"
        },
        {
          "name": "Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226;"
        }
      ]
    },
    {
      "given": "Melvin L.",
      "family": "Griem",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104;"
        },
        {
          "name": "Department of Neurosurgery, Hahnemann Medical College of Pennsylvania, Philadelphia, Pennsylvania 19102;"
        },
        {
          "name": "Departments of 3Pathology, 4Radiology, and 5Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois 60637;"
        },
        {
          "name": "Department of Electrical and Computer Engineering, Illinois Institute of Technology, Chicago, Illinois 60616;"
        },
        {
          "name": "Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226;"
        }
      ]
    },
    {
      "given": "Miles N.",
      "family": "Wernick",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104;"
        },
        {
          "name": "Department of Neurosurgery, Hahnemann Medical College of Pennsylvania, Philadelphia, Pennsylvania 19102;"
        },
        {
          "name": "Departments of 3Pathology, 4Radiology, and 5Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois 60637;"
        },
        {
          "name": "Department of Electrical and Computer Engineering, Illinois Institute of Technology, Chicago, Illinois 60616;"
        },
        {
          "name": "Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226;"
        }
      ]
    },
    {
      "given": "Elizabeth",
      "family": "Jacobs",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104;"
        },
        {
          "name": "Department of Neurosurgery, Hahnemann Medical College of Pennsylvania, Philadelphia, Pennsylvania 19102;"
        },
        {
          "name": "Departments of 3Pathology, 4Radiology, and 5Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois 60637;"
        },
        {
          "name": "Department of Electrical and Computer Engineering, Illinois Institute of Technology, Chicago, Illinois 60616;"
        },
        {
          "name": "Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226;"
        }
      ]
    },
    {
      "given": "Denise C.",
      "family": "Polacek",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104;"
        },
        {
          "name": "Department of Neurosurgery, Hahnemann Medical College of Pennsylvania, Philadelphia, Pennsylvania 19102;"
        },
        {
          "name": "Departments of 3Pathology, 4Radiology, and 5Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois 60637;"
        },
        {
          "name": "Department of Electrical and Computer Engineering, Illinois Institute of Technology, Chicago, Illinois 60616;"
        },
        {
          "name": "Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226;"
        }
      ]
    },
    {
      "given": "Natacha",
      "family": "DePaola",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104;"
        },
        {
          "name": "Department of Neurosurgery, Hahnemann Medical College of Pennsylvania, Philadelphia, Pennsylvania 19102;"
        },
        {
          "name": "Departments of 3Pathology, 4Radiology, and 5Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois 60637;"
        },
        {
          "name": "Department of Electrical and Computer Engineering, Illinois Institute of Technology, Chicago, Illinois 60616;"
        },
        {
          "name": "Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226;"
        }
      ]
    },
    {
      "given": "Abdul I.",
      "family": "Barakat",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104;"
        },
        {
          "name": "Department of Neurosurgery, Hahnemann Medical College of Pennsylvania, Philadelphia, Pennsylvania 19102;"
        },
        {
          "name": "Departments of 3Pathology, 4Radiology, and 5Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois 60637;"
        },
        {
          "name": "Department of Electrical and Computer Engineering, Illinois Institute of Technology, Chicago, Illinois 60616;"
        },
        {
          "name": "Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226;"
        }
      ]
    }
  ],
  "member": "22",
  "reference": [
    {
      "key": "b1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1096/fasebj.3.12.2477294"
    },
    {
      "key": "b2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF02368159"
    },
    {
      "key": "b3",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/bbrc.1993.1108"
    },
    {
      "key": "b4",
      "doi-asserted-by": "publisher",
      "DOI": "10.1161/01.RES.78.5.750"
    },
    {
      "key": "b5",
      "doi-asserted-by": "publisher",
      "DOI": "10.1161/01.RES.74.1.163"
    },
    {
      "key": "b6",
      "first-page": "1765",
      "volume": "268",
      "author": "Barbee KA",
      "year": "1995",
      "journal-title": "Am. J. Physiol."
    },
    {
      "key": "b7",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0021-9290(95)00092-5"
    },
    {
      "key": "b8",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0014-5793(92)81292-T"
    },
    {
      "key": "b9",
      "doi-asserted-by": "publisher",
      "DOI": "10.1159/000158963"
    },
    {
      "key": "b10",
      "doi-asserted-by": "publisher",
      "DOI": "10.1242/jcs.1987.Supplement_8.13"
    },
    {
      "key": "b11",
      "first-page": "18",
      "volume": "4",
      "author": "Burridge K",
      "year": "1986",
      "journal-title": "Cancer Res."
    },
    {
      "key": "b12",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.cb.04.110188.002415"
    },
    {
      "key": "b13",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/2231159a0"
    },
    {
      "key": "b14",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.7268440"
    },
    {
      "key": "b15",
      "author": "Chen J",
      "year": "1996",
      "journal-title": "Proc. IASTED Signal Image Process."
    },
    {
      "key": "b16",
      "doi-asserted-by": "crossref",
      "first-page": "1145",
      "DOI": "10.1242/jcs.104.4.1145",
      "volume": "104",
      "author": "Coan DE",
      "year": "1993",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "b17",
      "doi-asserted-by": "publisher",
      "DOI": "10.1172/JCI115481"
    },
    {
      "key": "b18",
      "first-page": "1",
      "volume": "88",
      "author": "Corson MA",
      "year": "1993",
      "journal-title": "Circulation"
    },
    {
      "key": "b19",
      "doi-asserted-by": "publisher",
      "DOI": "10.1152/physrev.1995.75.3.519"
    },
    {
      "key": "b20",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0021-9290(95)00102-6"
    },
    {
      "key": "b21",
      "doi-asserted-by": "publisher",
      "DOI": "10.1172/JCI116503"
    },
    {
      "key": "b22",
      "doi-asserted-by": "publisher",
      "DOI": "10.1172/JCI117197"
    },
    {
      "key": "b23",
      "doi-asserted-by": "publisher",
      "DOI": "10.1161/01.RES.72.2.239"
    },
    {
      "key": "b24",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/978-1-4684-7508-1_2"
    },
    {
      "key": "b25",
      "doi-asserted-by": "publisher",
      "DOI": "10.1115/1.3138276"
    },
    {
      "key": "b26",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/jcp.1041430222"
    },
    {
      "key": "b27",
      "first-page": "H653",
      "volume": "264",
      "author": "Falcone JC",
      "year": "1993",
      "journal-title": "Am. J. Physiol."
    },
    {
      "key": "b28",
      "unstructured": "Flitney FW, Goldman RD, Skalli O, Mercurius K, Davies PF. 1996. Dynamic properties of intermediate filaments in cultured endothelial cells: effects of controlled fluid shear stress. InThe Biology of Nitric Oxide, ed. S Moncada, J Stamler, S Gross, EA Higgs, p. 251. London: Portland"
    },
    {
      "key": "b29",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.88.5.1788"
    },
    {
      "key": "b30",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.3883488"
    },
    {
      "key": "b31",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/307648a0"
    },
    {
      "key": "b32",
      "unstructured": "Fry DL. 1973. Atherogenesis: initiating factors. InCiba Found. Symp. 12, pp. 96\u2013118. London: Ciba Found."
    },
    {
      "key": "b33",
      "doi-asserted-by": "publisher",
      "DOI": "10.1115/1.2895465"
    },
    {
      "key": "b34",
      "doi-asserted-by": "publisher",
      "DOI": "10.1152/ajpcell.1992.262.6.C1411"
    },
    {
      "key": "b35",
      "doi-asserted-by": "crossref",
      "first-page": "123",
      "DOI": "10.1055/s-0038-1642664",
      "volume": "74",
      "author": "Grabowski EF",
      "year": "1995",
      "journal-title": "Thromb. Hemost."
    },
    {
      "key": "b36",
      "doi-asserted-by": "crossref",
      "first-page": "197",
      "DOI": "10.1242/jcs.29.1.197",
      "volume": "29",
      "author": "Heath JP",
      "year": "1978",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "b37",
      "doi-asserted-by": "publisher",
      "DOI": "10.1097/00041433-199508000-00002"
    },
    {
      "key": "b38",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.105.1.291"
    },
    {
      "key": "b39",
      "doi-asserted-by": "publisher",
      "DOI": "10.1161/01.HYP.21.1.112"
    },
    {
      "key": "b40",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/362031a0"
    },
    {
      "key": "b41",
      "doi-asserted-by": "crossref",
      "first-page": "H590",
      "DOI": "10.1152/ajpcell.1994.266.3.C590",
      "volume": "266",
      "author": "Hutcheson IR",
      "year": "1994",
      "journal-title": "Am. J. Physiol."
    },
    {
      "key": "b42",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(92)90115-S"
    },
    {
      "key": "b43",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0955-0674(91)90058-7"
    },
    {
      "key": "b44",
      "unstructured": "Ingber DE, Jamieson JD. 1985. Cells as tensegrity structures: architectural regulation of histodifferentiation by physical forces transduced over basement membrane. InGene Expression During Normal and Malignant Differentiation, ed. LC Andersson, CG Gahmberg, P Ekblom, pp. 13\u201332. Orlando FL: Academic"
    },
    {
      "key": "b45",
      "doi-asserted-by": "crossref",
      "first-page": "81",
      "DOI": "10.1242/jcs.42.1.81",
      "volume": "42",
      "author": "Izzard CS",
      "year": "1980",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "b46",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00374386"
    },
    {
      "key": "b47",
      "first-page": "H962",
      "volume": "259",
      "author": "Kaiser L",
      "year": "1989",
      "journal-title": "Am. J. Physiol."
    },
    {
      "key": "b48",
      "doi-asserted-by": "publisher",
      "DOI": "10.1161/01.RES.72.6.1276"
    },
    {
      "key": "b49",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/bbrc.1994.1794"
    },
    {
      "key": "b50",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1476-5381.1990.tb12735.x"
    },
    {
      "key": "b51",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00392067"
    },
    {
      "key": "b52",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/355356a0"
    },
    {
      "key": "b53",
      "doi-asserted-by": "crossref",
      "first-page": "713",
      "DOI": "10.1242/jcs.109.4.713",
      "volume": "109",
      "author": "Malek AM",
      "year": "1996",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "b54",
      "doi-asserted-by": "crossref",
      "first-page": "17478",
      "DOI": "10.1016/S0021-9258(19)85359-0",
      "volume": "268",
      "author": "Marsden PA",
      "year": "1993",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b55",
      "doi-asserted-by": "publisher",
      "DOI": "10.1097/00002480-198907000-00036"
    },
    {
      "key": "b56",
      "doi-asserted-by": "crossref",
      "first-page": "A343",
      "DOI": "10.1096/fasebj.9.5.7534736",
      "volume": "9",
      "author": "McKinsey J",
      "year": "1995",
      "journal-title": "FASEB J."
    },
    {
      "key": "b57",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/cvr/23.9.741"
    },
    {
      "key": "b58",
      "doi-asserted-by": "publisher",
      "DOI": "10.1172/JCI117410"
    },
    {
      "key": "b59",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.85.6.1841"
    },
    {
      "key": "b60",
      "doi-asserted-by": "publisher",
      "DOI": "10.1115/1.3138275"
    },
    {
      "key": "b61",
      "doi-asserted-by": "publisher",
      "DOI": "10.1172/JCI116092"
    },
    {
      "key": "b62",
      "doi-asserted-by": "publisher",
      "DOI": "10.1161/01.CIR.88.1.193"
    },
    {
      "key": "b63",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/bbrc.1993.1624"
    },
    {
      "key": "b64",
      "doi-asserted-by": "publisher",
      "DOI": "10.1161/01.RES.73.3.492"
    },
    {
      "key": "b65",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/331168a0"
    },
    {
      "key": "b66",
      "first-page": "1",
      "volume": "88",
      "author": "Perry PB",
      "year": "1993",
      "journal-title": "Circulation"
    },
    {
      "key": "b67",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/bbrc.1993.2218"
    },
    {
      "key": "b68",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.90.10.4591"
    },
    {
      "key": "b69",
      "doi-asserted-by": "publisher",
      "DOI": "10.1096/fasebj.9.10.7615157"
    },
    {
      "key": "b70",
      "doi-asserted-by": "publisher",
      "DOI": "10.1353/pbm.1970.0054"
    },
    {
      "key": "b71",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0006-291X(92)91550-A"
    },
    {
      "key": "b72",
      "first-page": "141",
      "volume": "16",
      "author": "Sachs F",
      "year": "1988",
      "journal-title": "CRC Crit. Rev. Biomed. Eng."
    },
    {
      "key": "b73",
      "doi-asserted-by": "publisher",
      "DOI": "10.1115/1.2891388"
    },
    {
      "key": "b74",
      "doi-asserted-by": "publisher",
      "DOI": "10.1159/000159039"
    },
    {
      "key": "b75",
      "doi-asserted-by": "publisher",
      "DOI": "10.1161/01.RES.74.2.349"
    },
    {
      "key": "b76",
      "doi-asserted-by": "publisher",
      "DOI": "10.1152/ajpcell.1992.262.2.C384"
    },
    {
      "key": "b77",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.91.11.4678"
    },
    {
      "key": "b78",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0021-9290(95)00093-3"
    },
    {
      "key": "b79",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0022-5320(66)80127-2"
    },
    {
      "key": "b80",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00586515"
    },
    {
      "key": "b81",
      "doi-asserted-by": "publisher",
      "DOI": "10.1161/01.RES.77.5.869"
    },
    {
      "key": "b82",
      "doi-asserted-by": "publisher",
      "DOI": "10.1152/ajpcell.1995.269.6.C1371"
    },
    {
      "key": "b83",
      "unstructured": "Virchow R. 1860. InCellular Pathology as Based Upon Physiological and Pathological Histology. Transl. F Clance. London: Churchill (From German)"
    },
    {
      "key": "b84",
      "doi-asserted-by": "publisher",
      "DOI": "10.1161/01.ATV.15.1.2"
    },
    {
      "key": "b85",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.7684161"
    },
    {
      "key": "b86",
      "first-page": "639",
      "volume": "53",
      "author": "Wechezak AR",
      "year": "1985",
      "journal-title": "Lab. Invest."
    },
    {
      "key": "b87",
      "doi-asserted-by": "publisher",
      "DOI": "10.1067/mva.1987.avs0050413"
    },
    {
      "key": "b88",
      "doi-asserted-by": "publisher",
      "DOI": "10.1161/01.ATV.14.4.636"
    }
  ],
  "container-title": "Annual Review of Physiology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.annualreviews.org/doi/pdf/10.1146/annurev.physiol.59.1.527",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        10,
        17
      ]
    ],
    "date-time": "2021-10-17T00:03:58Z",
    "timestamp": 1634429038000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.annualreviews.org/doi/10.1146/annurev.physiol.59.1.527"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1997,
        10
      ]
    ]
  },
  "references-count": 88,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          1997,
          10
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1146/annurev.physiol.59.1.527"
  ],
  "URL": "http://dx.doi.org/10.1146/annurev.physiol.59.1.527",
  "relation": {},
  "ISSN": [
    "0066-4278",
    "1545-1585"
  ],
  "subject": [],
  "container-title-short": "Annu. Rev. Physiol.",
  "published": {
    "date-parts": [
      [
        1997,
        10
      ]
    ]
  }
}