DOI: 10.1146/annurev.physchem.59.032607.093606. Energy Flow in Proteins

10.1146/annurev.physchem.59.032607.093606

Crossref journal-article

Annual Reviews

Annual Review of Physical Chemistry (22)

Abstract

Energy flows anisotropically through the residues and vibrational states of globular proteins. A variety of experimental and computational studies have identified energy transport channels traversing many residues, in some cases connecting functional regions, potentially important in allostery, and in other cases having no apparent function. This property and the diffusion of energy in proteins are mimicked by transport on a percolation cluster. I review work that addresses connections between globular proteins, percolation clusters, and the similarity of energy flow and thermal transport in these systems. I also review experimental and theoretical studies of the anisotropic flow of energy through the vibrational states of a protein, a property that also can be understood by comparison with simple model disordered systems.

Bibliography

Leitner, D. M. (2008). Energy Flow in Proteins. Annual Review of Physical Chemistry, 59(1), 233â259.

Authors 1

David M. Leitner (first)

References 151 Referenced 285

10.1126/science.1118379
10.1021/jp014681b
10.1016/j.cplett.2006.10.092
10.1016/S0006-3495(96)79588-7
10.1038/nature05678
10.1021/bi051732c
10.1126/science.1120280
10.1146/annurev.pc.42.100191.003053
10.1016/j.bbapap.2005.02.005
10.1021/ja055251s
10.1016/j.sbi.2006.01.003
10.1021/bi0494424
10.1002/prot.20893
10.1126/science.286.5438.295
10.1016/j.jmb.2005.05.043
10.1002/prot.21146
10.1016/j.jmb.2006.08.076
10.1016/S0092-8674(04)00119-9
10.1038/nsb881
10.1073/pnas.83.23.8982
10.1016/j.cplett.2006.09.018
10.1021/jp034558f
10.1021/jp0107917
10.1063/1.1313554
10.1021/jp066340+
10.1021/ja061328g
10.1073/pnas.0409083102
10.1103/PhysRevLett.87.188102
10.1021/jp0206119
10.1002/0471712531.ch16
10.1103/PhysRevLett.85.3970
10.1021/jp027823q
10.1021/jp9813286
10.1016/S0301-0104(00)00182-8
10.1021/j100096a005
10.1021/jp982398f
10.1103/PhysRevLett.84.5435
10.1021/bi060652l
10.1002/prot.20232
10.1021/jp0351728
10.1126/science.278.5337.443
10.1021/jp9536458
10.1021/ja961198j
10.1021/ja017359n
10.1021/jp0276799
10.1073/pnas.0405295101
10.1016/S0006-3495(94)80793-3
10.1073/pnas.96.25.14324
10.1021/jp0654359
10.1073/pnas.0308315101
{'key': 'B50', 'first-page': '491', 'author': 'Fermi E', 'year': '1955', 'journal-title': 'Los Alamos Rep. LA-1940'} / Los Alamos Rep. LA-1940 by Fermi E (1955)
10.1016/0370-1573(91)90140-H
{'key': 'B52', 'first-page': '919', 'volume': '7', 'author': 'de Gennes PG', 'year': '1976', 'journal-title': 'Recherche'} / Recherche by de Gennes PG (1976)
10.1051/jphyslet:019820043017062500
10.1103/PhysRevLett.45.1456
10.1051/jphyslet:0198300440101300
10.1103/PhysRevLett.56.394
10.1063/1.1626636
10.1103/RevModPhys.66.381
10.1103/PhysRevE.71.011912
10.1103/PhysRevE.51.2600
10.1016/S0006-3495(01)75739-6
10.1103/PhysRevE.73.051905
10.1063/1.1830431
10.1103/PhysRevLett.80.2733
10.1002/prot.20072
10.1002/prot.340020407
10.1021/jp026462b
10.1021/jp035471x
10.1080/01442350600862117
10.1039/b516608j
10.1021/cr020661+
10.1103/PhysRevLett.88.138101
10.1016/S0006-3495(04)74252-6
10.1073/pnas.082335099
10.1021/jp020100m
10.1073/pnas.0607168103
10.1088/0031-8949/20/3-4/013
10.1103/PhysRevA.26.578
10.1073/pnas.0701762104
10.1103/PhysRevLett.95.098106
10.1126/science.1086911
10.1063/1.1524305
10.1038/35010065
10.1103/PhysRevE.61.2902
10.1103/PhysRevB.75.155312
10.1126/science.1132898
10.1103/PhysRevB.74.184305
10.1063/1.1900063
10.1209/epl/i1999-00374-9
10.1103/PhysRevB.48.12581
10.1126/science.253.5019.539
10.1103/PhysRevB.48.12589
10.1016/0009-2614(90)85172-9
10.1016/j.cplett.2004.09.107
10.1063/1.2009732
10.1021/bi00579a035
10.1146/annurev.physchem.51.1.323
10.1016/0301-0104(86)85020-0
10.1103/PhysRevLett.76.216
10.1063/1.458637
10.1063/1.447805
10.1063/1.464843
10.1021/jp960698w
10.1021/jp054263x
10.1021/j100009a034
10.1063/1.2155432
10.1021/jp0603334
10.1073/pnas.95.11.5960
10.1063/1.472920
10.1021/jp9619088
10.1146/annurev.pc.45.100194.001325
10.1016/0009-2614(96)00614-8
{'key': 'B113', 'first-page': '123', 'volume-title': 'Dynamics of Molecules and Chemical Reactions', 'author': 'Schofield SA', 'year': '1996'} / Dynamics of Molecules and Chemical Reactions by Schofield SA (1996)
10.1080/014423598230117
10.1126/science.1749933
10.1002/9780470141205.ch1
10.1017/CBO9781139167864
10.1103/PhysRev.128.2589
119. Deleted in proof
10.1201/9781420035070.ch16
10.1103/PhysRevLett.94.128101
10.1002/bip.10293
10.1146/annurev.physchem.52.1.315
10.1021/jp963226q
10.1103/PhysRevB.64.094201
10.1016/S0009-2614(02)00761-3
10.1016/j.jmb.2005.08.072
10.1146/annurev.physchem.58.032806.104456
10.1073/pnas.0508833103
10.1002/prot.20749
10.1073/pnas.96.18.10118
10.1016/S0006-3495(98)77495-8
10.1002/prot.10578
10.1103/PhysRevLett.88.018102
10.1021/j100324a007
10.1021/j100334a007
10.1063/1.1700424
10.1093/oso/9780195074949.001.0001 / Unimolecular Reaction Dynamics: Theory and Experiment by Baer T (1996)
10.1016/S0006-3495(03)75054-1
10.1016/j.chemphys.2006.05.013
10.1063/1.2713109
10.1063/1.2754689
10.1016/S0009-2614(97)01120-2
10.1021/j100322a038
10.1063/1.2011399
10.1002/(SICI)1097-461X(1999)75:4/5<523::AID-QUA17>3.0.CO;2-U
10.1021/jp0305180
10.1021/jp000173a
10.1016/j.cplett.2004.04.100
10.1039/b212699k

Dates

Type	When
Created	17 years, 4 months ago (April 4, 2008, 6:54 p.m.)
Deposited	3 years, 10 months ago (Oct. 16, 2021, 8:38 a.m.)
Indexed	2 weeks, 4 days ago (Aug. 6, 2025, 9:41 a.m.)
Issued	17 years, 3 months ago (May 1, 2008)
Published	17 years, 3 months ago (May 1, 2008)
Published Print	17 years, 3 months ago (May 1, 2008)

Funders 0

None

BibTeX

@article{Leitner_2008, title={Energy Flow in Proteins}, volume={59}, ISSN={1545-1593}, url={http://dx.doi.org/10.1146/annurev.physchem.59.032607.093606}, DOI={10.1146/annurev.physchem.59.032607.093606}, number={1}, journal={Annual Review of Physical Chemistry}, publisher={Annual Reviews}, author={Leitner, David M.}, year={2008}, month=may, pages={233–259} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        6
      ]
    ],
    "date-time": "2025-08-06T13:41:46Z",
    "timestamp": 1754487706446
  },
  "reference-count": 151,
  "publisher": "Annual Reviews",
  "issue": "1",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2008,
        5,
        1
      ]
    ]
  },
  "abstract": "<jats:p> Energy flows anisotropically through the residues and vibrational states of globular proteins. A variety of experimental and computational studies have identified energy transport channels traversing many residues, in some cases connecting functional regions, potentially important in allostery, and in other cases having no apparent function. This property and the diffusion of energy in proteins are mimicked by transport on a percolation cluster. I review work that addresses connections between globular proteins, percolation clusters, and the similarity of energy flow and thermal transport in these systems. I also review experimental and theoretical studies of the anisotropic flow of energy through the vibrational states of a protein, a property that also can be understood by comparison with simple model disordered systems. </jats:p>",
  "DOI": "10.1146/annurev.physchem.59.032607.093606",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2008,
        4,
        4
      ]
    ],
    "date-time": "2008-04-04T22:54:21Z",
    "timestamp": 1207349661000
  },
  "page": "233-259",
  "source": "Crossref",
  "is-referenced-by-count": 285,
  "title": "Energy Flow in Proteins",
  "prefix": "10.1146",
  "volume": "59",
  "author": [
    {
      "given": "David M.",
      "family": "Leitner",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Department of Chemistry and Chemical Physics Program, University of Nevada, Reno, Nevada 89557;"
        }
      ]
    }
  ],
  "member": "22",
  "reference": [
    {
      "key": "B1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.1118379"
    },
    {
      "key": "B2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jp014681b"
    },
    {
      "key": "B3",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.cplett.2006.10.092"
    },
    {
      "key": "B4",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0006-3495(96)79588-7"
    },
    {
      "key": "B5",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/nature05678"
    },
    {
      "key": "B6",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi051732c"
    },
    {
      "key": "B7",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.1120280"
    },
    {
      "key": "B8",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.pc.42.100191.003053"
    },
    {
      "key": "B9",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.bbapap.2005.02.005"
    },
    {
      "key": "B10",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ja055251s"
    },
    {
      "key": "B10a",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.sbi.2006.01.003"
    },
    {
      "key": "B11",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi0494424"
    },
    {
      "key": "B12",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/prot.20893"
    },
    {
      "key": "B13",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.286.5438.295"
    },
    {
      "key": "B14",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.jmb.2005.05.043"
    },
    {
      "key": "B15",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/prot.21146"
    },
    {
      "key": "B16",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.jmb.2006.08.076"
    },
    {
      "key": "B17",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(04)00119-9"
    },
    {
      "key": "B18",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/nsb881"
    },
    {
      "key": "B19",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.83.23.8982"
    },
    {
      "key": "B20",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.cplett.2006.09.018"
    },
    {
      "key": "B21",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jp034558f"
    },
    {
      "key": "B22",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jp0107917"
    },
    {
      "key": "B23",
      "doi-asserted-by": "publisher",
      "DOI": "10.1063/1.1313554"
    },
    {
      "key": "B24",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jp066340+"
    },
    {
      "key": "B25",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ja061328g"
    },
    {
      "key": "B26",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.0409083102"
    },
    {
      "key": "B27",
      "doi-asserted-by": "publisher",
      "DOI": "10.1103/PhysRevLett.87.188102"
    },
    {
      "key": "B28",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jp0206119"
    },
    {
      "key": "B29",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/0471712531.ch16"
    },
    {
      "key": "B30",
      "doi-asserted-by": "publisher",
      "DOI": "10.1103/PhysRevLett.85.3970"
    },
    {
      "key": "B31",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jp027823q"
    },
    {
      "key": "B32",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jp9813286"
    },
    {
      "key": "B33",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0301-0104(00)00182-8"
    },
    {
      "key": "B34",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/j100096a005"
    },
    {
      "key": "B35",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jp982398f"
    },
    {
      "key": "B36",
      "doi-asserted-by": "publisher",
      "DOI": "10.1103/PhysRevLett.84.5435"
    },
    {
      "key": "B37",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi060652l"
    },
    {
      "key": "B38",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/prot.20232"
    },
    {
      "key": "B39",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jp0351728"
    },
    {
      "key": "B40",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.278.5337.443"
    },
    {
      "key": "B41",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jp9536458"
    },
    {
      "key": "B42",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ja961198j"
    },
    {
      "key": "B43",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ja017359n"
    },
    {
      "key": "B44",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jp0276799"
    },
    {
      "key": "B45",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.0405295101"
    },
    {
      "key": "B46",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0006-3495(94)80793-3"
    },
    {
      "key": "B47",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.96.25.14324"
    },
    {
      "key": "B48",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jp0654359"
    },
    {
      "key": "B49",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.0308315101"
    },
    {
      "key": "B50",
      "first-page": "491",
      "author": "Fermi E",
      "year": "1955",
      "journal-title": "Los Alamos Rep. LA-1940"
    },
    {
      "key": "B51",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0370-1573(91)90140-H"
    },
    {
      "key": "B52",
      "first-page": "919",
      "volume": "7",
      "author": "de Gennes PG",
      "year": "1976",
      "journal-title": "Recherche"
    },
    {
      "key": "B53",
      "doi-asserted-by": "publisher",
      "DOI": "10.1051/jphyslet:019820043017062500"
    },
    {
      "key": "B54",
      "doi-asserted-by": "publisher",
      "DOI": "10.1103/PhysRevLett.45.1456"
    },
    {
      "key": "B55",
      "doi-asserted-by": "publisher",
      "DOI": "10.1051/jphyslet:0198300440101300"
    },
    {
      "key": "B56",
      "doi-asserted-by": "publisher",
      "DOI": "10.1103/PhysRevLett.56.394"
    },
    {
      "key": "B57",
      "doi-asserted-by": "publisher",
      "DOI": "10.1063/1.1626636"
    },
    {
      "key": "B58",
      "doi-asserted-by": "publisher",
      "DOI": "10.1103/RevModPhys.66.381"
    },
    {
      "key": "B59",
      "doi-asserted-by": "publisher",
      "DOI": "10.1103/PhysRevE.71.011912"
    },
    {
      "key": "B60",
      "doi-asserted-by": "publisher",
      "DOI": "10.1103/PhysRevE.51.2600"
    },
    {
      "key": "B61",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0006-3495(01)75739-6"
    },
    {
      "key": "B62",
      "doi-asserted-by": "publisher",
      "DOI": "10.1103/PhysRevE.73.051905"
    },
    {
      "key": "B63",
      "doi-asserted-by": "publisher",
      "DOI": "10.1063/1.1830431"
    },
    {
      "key": "B64",
      "doi-asserted-by": "publisher",
      "DOI": "10.1103/PhysRevLett.80.2733"
    },
    {
      "key": "B65",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/prot.20072"
    },
    {
      "key": "B66",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/prot.340020407"
    },
    {
      "key": "B67",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jp026462b"
    },
    {
      "key": "B68",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jp035471x"
    },
    {
      "key": "B69",
      "doi-asserted-by": "publisher",
      "DOI": "10.1080/01442350600862117"
    },
    {
      "key": "B70",
      "doi-asserted-by": "publisher",
      "DOI": "10.1039/b516608j"
    },
    {
      "key": "B71",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/cr020661+"
    },
    {
      "key": "B72",
      "doi-asserted-by": "publisher",
      "DOI": "10.1103/PhysRevLett.88.138101"
    },
    {
      "key": "B73",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0006-3495(04)74252-6"
    },
    {
      "key": "B74",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.082335099"
    },
    {
      "key": "B75",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jp020100m"
    },
    {
      "key": "B76",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.0607168103"
    },
    {
      "key": "B77",
      "doi-asserted-by": "publisher",
      "DOI": "10.1088/0031-8949/20/3-4/013"
    },
    {
      "key": "B78",
      "doi-asserted-by": "publisher",
      "DOI": "10.1103/PhysRevA.26.578"
    },
    {
      "key": "B79",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.0701762104"
    },
    {
      "key": "B80",
      "doi-asserted-by": "publisher",
      "DOI": "10.1103/PhysRevLett.95.098106"
    },
    {
      "key": "B81",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.1086911"
    },
    {
      "key": "B82",
      "doi-asserted-by": "publisher",
      "DOI": "10.1063/1.1524305"
    },
    {
      "key": "B83",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/35010065"
    },
    {
      "key": "B84",
      "doi-asserted-by": "publisher",
      "DOI": "10.1103/PhysRevE.61.2902"
    },
    {
      "key": "B85",
      "doi-asserted-by": "publisher",
      "DOI": "10.1103/PhysRevB.75.155312"
    },
    {
      "key": "B86",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.1132898"
    },
    {
      "key": "B87",
      "doi-asserted-by": "publisher",
      "DOI": "10.1103/PhysRevB.74.184305"
    },
    {
      "key": "B88",
      "doi-asserted-by": "publisher",
      "DOI": "10.1063/1.1900063"
    },
    {
      "key": "B89",
      "doi-asserted-by": "publisher",
      "DOI": "10.1209/epl/i1999-00374-9"
    },
    {
      "key": "B90",
      "doi-asserted-by": "publisher",
      "DOI": "10.1103/PhysRevB.48.12581"
    },
    {
      "key": "B91",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.253.5019.539"
    },
    {
      "key": "B92",
      "doi-asserted-by": "publisher",
      "DOI": "10.1103/PhysRevB.48.12589"
    },
    {
      "key": "B93",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0009-2614(90)85172-9"
    },
    {
      "key": "B94",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.cplett.2004.09.107"
    },
    {
      "key": "B95",
      "doi-asserted-by": "publisher",
      "DOI": "10.1063/1.2009732"
    },
    {
      "key": "B96",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi00579a035"
    },
    {
      "key": "B97",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.physchem.51.1.323"
    },
    {
      "key": "B98",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0301-0104(86)85020-0"
    },
    {
      "key": "B99",
      "doi-asserted-by": "publisher",
      "DOI": "10.1103/PhysRevLett.76.216"
    },
    {
      "key": "B100",
      "doi-asserted-by": "publisher",
      "DOI": "10.1063/1.458637"
    },
    {
      "key": "B101",
      "doi-asserted-by": "publisher",
      "DOI": "10.1063/1.447805"
    },
    {
      "key": "B102",
      "doi-asserted-by": "publisher",
      "DOI": "10.1063/1.464843"
    },
    {
      "key": "B103",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jp960698w"
    },
    {
      "key": "B104",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jp054263x"
    },
    {
      "key": "B105",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/j100009a034"
    },
    {
      "key": "B106",
      "doi-asserted-by": "publisher",
      "DOI": "10.1063/1.2155432"
    },
    {
      "key": "B107",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jp0603334"
    },
    {
      "key": "B108",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.95.11.5960"
    },
    {
      "key": "B109",
      "doi-asserted-by": "publisher",
      "DOI": "10.1063/1.472920"
    },
    {
      "key": "B110",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jp9619088"
    },
    {
      "key": "B111",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.pc.45.100194.001325"
    },
    {
      "key": "B112",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0009-2614(96)00614-8"
    },
    {
      "key": "B113",
      "first-page": "123",
      "volume-title": "Dynamics of Molecules and Chemical Reactions",
      "author": "Schofield SA",
      "year": "1996"
    },
    {
      "key": "B114",
      "doi-asserted-by": "publisher",
      "DOI": "10.1080/014423598230117"
    },
    {
      "key": "B115",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.1749933"
    },
    {
      "key": "B116",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/9780470141205.ch1"
    },
    {
      "key": "B117",
      "doi-asserted-by": "publisher",
      "DOI": "10.1017/CBO9781139167864"
    },
    {
      "key": "B118",
      "doi-asserted-by": "publisher",
      "DOI": "10.1103/PhysRev.128.2589"
    },
    {
      "key": "B119",
      "unstructured": "119.\u2002Deleted in proof"
    },
    {
      "key": "B120",
      "doi-asserted-by": "publisher",
      "DOI": "10.1201/9781420035070.ch16"
    },
    {
      "key": "B121",
      "doi-asserted-by": "publisher",
      "DOI": "10.1103/PhysRevLett.94.128101"
    },
    {
      "key": "B122",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/bip.10293"
    },
    {
      "key": "B123",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.physchem.52.1.315"
    },
    {
      "key": "B124",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jp963226q"
    },
    {
      "key": "B125",
      "doi-asserted-by": "publisher",
      "DOI": "10.1103/PhysRevB.64.094201"
    },
    {
      "key": "B126",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0009-2614(02)00761-3"
    },
    {
      "key": "B127",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.jmb.2005.08.072"
    },
    {
      "key": "B128",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.physchem.58.032806.104456"
    },
    {
      "key": "B129",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.0508833103"
    },
    {
      "key": "B130",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/prot.20749"
    },
    {
      "key": "B131",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.96.18.10118"
    },
    {
      "key": "B132",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0006-3495(98)77495-8"
    },
    {
      "key": "B133",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/prot.10578"
    },
    {
      "key": "B134",
      "doi-asserted-by": "publisher",
      "DOI": "10.1103/PhysRevLett.88.018102"
    },
    {
      "key": "B135",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/j100324a007"
    },
    {
      "key": "B136",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/j100334a007"
    },
    {
      "key": "B137",
      "doi-asserted-by": "publisher",
      "DOI": "10.1063/1.1700424"
    },
    {
      "key": "B138",
      "doi-asserted-by": "crossref",
      "DOI": "10.1093/oso/9780195074949.001.0001",
      "volume-title": "Unimolecular Reaction Dynamics: Theory and Experiment",
      "author": "Baer T",
      "year": "1996"
    },
    {
      "key": "B139",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0006-3495(03)75054-1"
    },
    {
      "key": "B140",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.chemphys.2006.05.013"
    },
    {
      "key": "B141",
      "doi-asserted-by": "publisher",
      "DOI": "10.1063/1.2713109"
    },
    {
      "key": "B142",
      "doi-asserted-by": "publisher",
      "DOI": "10.1063/1.2754689"
    },
    {
      "key": "B143",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0009-2614(97)01120-2"
    },
    {
      "key": "B144",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/j100322a038"
    },
    {
      "key": "B145",
      "doi-asserted-by": "publisher",
      "DOI": "10.1063/1.2011399"
    },
    {
      "key": "B146",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/(SICI)1097-461X(1999)75:4/5<523::AID-QUA17>3.0.CO;2-U"
    },
    {
      "key": "B147",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jp0305180"
    },
    {
      "key": "B148",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jp000173a"
    },
    {
      "key": "B149",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.cplett.2004.04.100"
    },
    {
      "key": "B150",
      "doi-asserted-by": "publisher",
      "DOI": "10.1039/b212699k"
    }
  ],
  "container-title": "Annual Review of Physical Chemistry",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.annualreviews.org/doi/pdf/10.1146/annurev.physchem.59.032607.093606",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        10,
        16
      ]
    ],
    "date-time": "2021-10-16T12:38:58Z",
    "timestamp": 1634387938000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.annualreviews.org/doi/10.1146/annurev.physchem.59.032607.093606"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2008,
        5,
        1
      ]
    ]
  },
  "references-count": 151,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          2008,
          5,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1146/annurev.physchem.59.032607.093606"
  ],
  "URL": "http://dx.doi.org/10.1146/annurev.physchem.59.032607.093606",
  "relation": {},
  "ISSN": [
    "0066-426X",
    "1545-1593"
  ],
  "subject": [],
  "container-title-short": "Annu. Rev. Phys. Chem.",
  "published": {
    "date-parts": [
      [
        2008,
        5,
        1
      ]
    ]
  }
}