DOI: 10.1146/annurev.pharmtox.48.113006.094723. Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy

Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy

10.1146/annurev.pharmtox.48.113006.094723

Crossref journal-article

Annual Reviews

Annual Review of Pharmacology and Toxicology (22)

Abstract

Tumor suppressor p53 is an attractive cancer therapeutic target because it can be functionally activated to eradicate tumors. Direct gene alterations in p53 or interaction between p53 and MDM2 proteins are two alternative mechanisms for the inactivation of p53 function. Designing small molecules to block the MDM2-p53 interaction and reactivate the p53 function is a promising therapeutic strategy for the treatment of cancers retaining wild-type p53. This review will highlight recent advances in the design and development of small-molecule inhibitors of the MDM2-p53 interaction as new cancer therapies. A number of these small-molecule inhibitors, such as analogs of MI-219 and Nutlin-3, have progressed to advanced preclinical development or early phase cinical trials.

Bibliography

Shangary, S., & Wang, S. (2009). Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy. Annual Review of Pharmacology and Toxicology, 49(1), 223â241.

Authors 2

Sanjeev Shangary (first)
Shaomeng Wang (additional)

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Dates

Type	When
Created	16 years, 10 months ago (Oct. 3, 2008, 5:19 p.m.)
Deposited	3 years, 10 months ago (Oct. 16, 2021, 4:50 a.m.)
Indexed	4 weeks, 1 day ago (July 22, 2025, 7:03 a.m.)
Issued	16 years, 6 months ago (Feb. 1, 2009)
Published	16 years, 6 months ago (Feb. 1, 2009)
Published Print	16 years, 6 months ago (Feb. 1, 2009)

Funders 0

None

BibTeX

@article{Shangary_2009, title={Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy}, volume={49}, ISSN={1545-4304}, url={http://dx.doi.org/10.1146/annurev.pharmtox.48.113006.094723}, DOI={10.1146/annurev.pharmtox.48.113006.094723}, number={1}, journal={Annual Review of Pharmacology and Toxicology}, publisher={Annual Reviews}, author={Shangary, Sanjeev and Wang, Shaomeng}, year={2009}, month=feb, pages={223–241} }

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