DOI: 10.1146/annurev.pharmtox.43.100901.135803. Trafficking of NMDA Receptors

10.1146/annurev.pharmtox.43.100901.135803

Crossref journal-article

Annual Reviews

Annual Review of Pharmacology and Toxicology (22)

Abstract

The NMDA receptor (NMDAR) plays a central role in the function of excitatory synapses. Recent studies have provided interesting insights into several aspects of the trafficking of this receptor in neurons. The NMDAR is not a static resident of the synapse. Rather, the number and composition of synaptic NMDARs can be modulated by several factors. The interaction of PDZ proteins, generally thought to occur at the synapse, appears to occur early in the secretory pathway; this interaction may play a role in the assembly of the receptor complex and its exit from the endoplasmic reticulum. This review addresses recent advances in our understanding of NMDAR trafficking and its synaptic delivery and maintenance.

Bibliography

Wenthold, R. J., Prybylowski, K., Standley, S., Sans, N., & Petralia, R. S. (2003). Trafficking of NMDA Receptors. Annual Review of Pharmacology and Toxicology, 43(1), 335â358.

Authors 5

Robert J. Wenthold (first)
Kate Prybylowski (additional)
Steve Standley (additional)
Nathalie Sans (additional)
Ronald S. Petralia (additional)

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Dates

Type	When
Created	22 years, 7 months ago (Jan. 22, 2003, 5:17 p.m.)
Deposited	3 years, 10 months ago (Oct. 16, 2021, 6:32 a.m.)
Indexed	2 months ago (July 3, 2025, 2:03 p.m.)
Issued	22 years, 5 months ago (April 1, 2003)
Published	22 years, 5 months ago (April 1, 2003)
Published Print	22 years, 5 months ago (April 1, 2003)

Funders 0

None

BibTeX

@article{Wenthold_2003, title={Trafficking of NMDA Receptors}, volume={43}, ISSN={1545-4304}, url={http://dx.doi.org/10.1146/annurev.pharmtox.43.100901.135803}, DOI={10.1146/annurev.pharmtox.43.100901.135803}, number={1}, journal={Annual Review of Pharmacology and Toxicology}, publisher={Annual Reviews}, author={Wenthold, Robert J. and Prybylowski, Kate and Standley, Steve and Sans, Nathalie and Petralia, Ronald S.}, year={2003}, month=apr, pages={335–358} }

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