DOI: 10.1146/annurev.neuro.29.051605.112834. ENDOCANNABINOID-MEDIATED SYNAPTIC PLASTICITY IN THE CNS

ENDOCANNABINOID-MEDIATED SYNAPTIC PLASTICITY IN THE CNS
10.1146/annurev.neuro.29.051605.112834
Crossref journal-article
Annual Reviews
Annual Review of Neuroscience (22)
Abstract
Changes in synaptic efficacy are thought to be crucial to experience-dependent modifications of neural function. The diversity of mechanisms underlying these changes is far greater than previously expected. In the last five years, a new class of use-dependent synaptic plasticity that requires retrograde signaling by endocannabinoids (eCB) and presynaptic CB1 receptor activation has been identified in several brain structures. eCB-mediated plasticity encompasses many forms of transient and long-lasting synaptic depression and is found at both excitatory and inhibitory synapses. In addition, eCBs can modify the inducibility of non-eCB-mediated forms of plasticity. Thus, the eCB system is emerging as a major player in synaptic plasticity. Given the wide distribution of CB1 receptors in the CNS, the list of brain structures and synapses expressing eCB-mediated plasticity is likely to expand.
Bibliography
Chevaleyre, V., Takahashi, K. A., & Castillo, P. E. (2006). ENDOCANNABINOID-MEDIATED SYNAPTIC PLASTICITY IN THE CNS. Annual Review of Neuroscience, 29(1), 37â76.
Authors 3
Vivien Chevaleyre (first)
Kanji A. Takahashi (additional)
Pablo E. Castillo (additional)
References 258 Referenced 639
Dates
Type	When
Created	19 years, 4 months ago (April 7, 2006, 10 a.m.)
Deposited	3 years, 10 months ago (Oct. 14, 2021, 8:39 p.m.)
Indexed	1 day, 20 hours ago (Sept. 3, 2025, 6:08 a.m.)
Issued	19 years, 1 month ago (July 21, 2006)
Published	19 years, 1 month ago (July 21, 2006)
Published Print	19 years, 1 month ago (July 21, 2006)
Funders 0
None
BibTeX
@article{Chevaleyre_2006, title={ENDOCANNABINOID-MEDIATED SYNAPTIC PLASTICITY IN THE CNS}, volume={29}, ISSN={1545-4126}, url={http://dx.doi.org/10.1146/annurev.neuro.29.051605.112834}, DOI={10.1146/annurev.neuro.29.051605.112834}, number={1}, journal={Annual Review of Neuroscience}, publisher={Annual Reviews}, author={Chevaleyre, Vivien and Takahashi, Kanji A. and Castillo, Pablo E.}, year={2006}, month=jul, pages={37–76} }
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  "abstract": "<jats:p> Changes in synaptic efficacy are thought to be crucial to experience-dependent modifications of neural function. The diversity of mechanisms underlying these changes is far greater than previously expected. In the last five years, a new class of use-dependent synaptic plasticity that requires retrograde signaling by endocannabinoids (eCB) and presynaptic CB1 receptor activation has been identified in several brain structures. eCB-mediated plasticity encompasses many forms of transient and long-lasting synaptic depression and is found at both excitatory and inhibitory synapses. In addition, eCBs can modify the inducibility of non-eCB-mediated forms of plasticity. Thus, the eCB system is emerging as a major player in synaptic plasticity. Given the wide distribution of CB1 receptors in the CNS, the list of brain structures and synapses expressing eCB-mediated plasticity is likely to expand. </jats:p>",
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