BRAIN WORK AND BRAIN IMAGING
10.1146/annurev.neuro.29.051605.112819
Crossref journal-article
Annual Reviews
Annual Review of Neuroscience (22)
Abstract

Functional brain imaging with positron emission tomography and magnetic resonance imaging has been used extensively to map regional changes in brain activity. The signal used by both techniques is based on changes in local circulation and metabolism (brain work). Our understanding of the cell biology of these changes has progressed greatly in the past decade. New insights have emerged on the role of astrocytes in signal transduction as has an appreciation of the unique contribution of aerobic glycolysis to brain energy metabolism. Likewise our understanding of the neurophysiologic processes responsible for imaging signals has progressed from an assumption that spiking activity (output) of neurons is most relevant to one focused on their input. Finally, neuroimaging, with its unique metabolic perspective, has alerted us to the ongoing and costly intrinsic activity within brain systems that most likely represents the largest fraction of the brain's functional activity.

Bibliography

Raichle, M. E., & Mintun, M. A. (2006). BRAIN WORK AND BRAIN IMAGING. Annual Review of Neuroscience, 29(1), 449–476.

Authors 2
  1. Marcus E. Raichle (first)
  2. Mark A. Mintun (additional)
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Dates
Type When
Created 19 years, 4 months ago (April 7, 2006, 10 a.m.)
Deposited 1 year, 6 months ago (Feb. 3, 2024, 12:02 p.m.)
Indexed 1 day, 22 hours ago (Aug. 26, 2025, 2:47 a.m.)
Issued 19 years, 1 month ago (July 21, 2006)
Published 19 years, 1 month ago (July 21, 2006)
Published Print 19 years, 1 month ago (July 21, 2006)
Funders 0

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@article{Raichle_2006, title={BRAIN WORK AND BRAIN IMAGING}, volume={29}, ISSN={1545-4126}, url={http://dx.doi.org/10.1146/annurev.neuro.29.051605.112819}, DOI={10.1146/annurev.neuro.29.051605.112819}, number={1}, journal={Annual Review of Neuroscience}, publisher={Annual Reviews}, author={Raichle, Marcus E. and Mintun, Mark A.}, year={2006}, month=jul, pages={449–476} }