PLASTICITY OF THE SPINAL NEURAL CIRCUITRY AFTER INJURY
10.1146/annurev.neuro.27.070203.144308
Crossref journal-article
Annual Reviews
Annual Review of Neuroscience (22)
Abstract

▪ Abstract  Motor function is severely disrupted following spinal cord injury (SCI). The spinal circuitry, however, exhibits a great degree of automaticity and plasticity after an injury. Automaticity implies that the spinal circuits have some capacity to perform complex motor tasks following the disruption of supraspinal input, and evidence for plasticity suggests that biochemical changes at the cellular level in the spinal cord can be induced in an activity-dependent manner that correlates with sensorimotor recovery. These characteristics should be strongly considered as advantageous in developing therapeutic strategies to assist in the recovery of locomotor function following SCI. Rehabilitative efforts combining locomotor training pharmacological means and/or spinal cord electrical stimulation paradigms will most likely result in more effective methods of recovery than using only one intervention.

Bibliography

Edgerton, V. R., Tillakaratne, N. J. K., Bigbee, A. J., de Leon, R. D., & Roy, R. R. (2004). PLASTICITY OF THE SPINAL NEURAL CIRCUITRY AFTER INJURY. Annual Review of Neuroscience, 27(1), 145–167.

Authors 5
  1. V. Reggie Edgerton (first)
  2. Niranjala J.K. Tillakaratne (additional)
  3. Allison J. Bigbee (additional)
  4. Ray D. de Leon (additional)
  5. Roland R. Roy (additional)
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Dates
Type When
Created 21 years, 2 months ago (June 24, 2004, 3:36 p.m.)
Deposited 3 years, 10 months ago (Oct. 14, 2021, 2:59 p.m.)
Indexed 3 days, 10 hours ago (Aug. 29, 2025, 6:34 a.m.)
Issued 21 years, 1 month ago (July 21, 2004)
Published 21 years, 1 month ago (July 21, 2004)
Published Print 21 years, 1 month ago (July 21, 2004)
Funders 0

None

@article{Edgerton_2004, title={PLASTICITY OF THE SPINAL NEURAL CIRCUITRY AFTER INJURY}, volume={27}, ISSN={1545-4126}, url={http://dx.doi.org/10.1146/annurev.neuro.27.070203.144308}, DOI={10.1146/annurev.neuro.27.070203.144308}, number={1}, journal={Annual Review of Neuroscience}, publisher={Annual Reviews}, author={Edgerton, V. Reggie and Tillakaratne, Niranjala J.K. and Bigbee, Allison J. and de Leon, Ray D. and Roy, Roland R.}, year={2004}, month=jul, pages={145–167} }