DOI: 10.1146/annurev.neuro.24.1.1. PDZ Domains and the Organization of Supramolecular Complexes

PDZ Domains and the Organization of Supramolecular Complexes

10.1146/annurev.neuro.24.1.1

Crossref journal-article

Annual Reviews

Annual Review of Neuroscience (22)

Abstract

▪ Abstract PDZ domains are modular protein interaction domains that bind in a sequence-specific fashion to short C-terminal peptides or internal peptides that fold in a β-finger. The diversity of PDZ binding specificities can be explained by variable amino acids lining the peptide-binding groove of the PDZ domain. Abundantly represented in Caenorhabditis elegans, Drosophila melanogaster, and mammalian genomes, PDZ domains are frequently found in multiple copies or are associated with other protein-binding motifs in multidomain scaffold proteins. PDZ-containing proteins are typically involved in the assembly of supramolecular complexes that perform localized signaling functions at particular subcellular locations. Organization around a PDZ-based scaffold allows the stable localization of interacting proteins and enhances the rate and fidelity of signal transduction within the complex. Some PDZ-containing proteins are more dynamically regulated in distribution and may also be involved in the trafficking of interacting proteins within the cell.

Bibliography

Sheng, M., & Sala, C. (2001). PDZ Domains and the Organization of Supramolecular Complexes. Annual Review of Neuroscience, 24(1), 1â29.

Authors 2

Morgan Sheng (first)
Carlo Sala (additional)

References 143 Referenced 1,002

Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 7:45 a.m.)
Deposited	3 years, 10 months ago (Oct. 14, 2021, 10:36 p.m.)
Indexed	2 days, 17 hours ago (Aug. 26, 2025, 3:15 a.m.)
Issued	24 years, 5 months ago (March 1, 2001)
Published	24 years, 5 months ago (March 1, 2001)
Published Print	24 years, 5 months ago (March 1, 2001)

Funders 0

None

BibTeX

@article{Sheng_2001, title={PDZ Domains and the Organization of Supramolecular Complexes}, volume={24}, ISSN={1545-4126}, url={http://dx.doi.org/10.1146/annurev.neuro.24.1.1}, DOI={10.1146/annurev.neuro.24.1.1}, number={1}, journal={Annual Review of Neuroscience}, publisher={Annual Reviews}, author={Sheng, Morgan and Sala, Carlo}, year={2001}, month=mar, pages={1–29} }

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  "abstract": "<jats:p> \u25aa Abstract\u2002 PDZ domains are modular protein interaction domains that bind in a sequence-specific fashion to short C-terminal peptides or internal peptides that fold in a \u03b2-finger. The diversity of PDZ binding specificities can be explained by variable amino acids lining the peptide-binding groove of the PDZ domain. Abundantly represented in Caenorhabditis elegans, Drosophila melanogaster, and mammalian genomes, PDZ domains are frequently found in multiple copies or are associated with other protein-binding motifs in multidomain scaffold proteins. PDZ-containing proteins are typically involved in the assembly of supramolecular complexes that perform localized signaling functions at particular subcellular locations. Organization around a PDZ-based scaffold allows the stable localization of interacting proteins and enhances the rate and fidelity of signal transduction within the complex. Some PDZ-containing proteins are more dynamically regulated in distribution and may also be involved in the trafficking of interacting proteins within the cell. </jats:p>",
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