BCL-2 GENE FAMILY IN THE NERVOUS SYSTEM
10.1146/annurev.neuro.20.1.245
Crossref journal-article
Annual Reviews
Annual Review of Neuroscience (22)
Abstract

▪ Abstract  A growing family of genes that share homology with the bcl-2 proto-oncogene is involved in the regulation of cell death. Many of these proteins show widespread expression and are expressed in the nervous system in developing and adult organisms. A physiologic role for Bcl-2 and Bcl-x in neuron survival has been shown. In addition, these proteins have been shown to protect neurons from a wide array of toxic insults. In this review, we discuss the Bcl-2 family of proteins with regard to their structure and interactions. We then discuss the role of apoptotic cell death in the development of the nervous system and as a response to neuronal injury. Lastly, we discuss the evidence for a role for these cell death regulators in neuronal death decisions.

Bibliography

Merry, D. E., & Korsmeyer, S. J. (1997). BCL-2 GENE FAMILY IN THE NERVOUS SYSTEM. Annual Review of Neuroscience, 20(1), 245–267.

Authors 2 University of Pennsylvania
  1. D. E. Merry (first) University of Pennsylvania
  2. S. J. Korsmeyer (additional)
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Dates
Type When
Created 23 years, 1 month ago (July 27, 2002, 7:45 a.m.)
Deposited 2 years, 4 months ago (April 23, 2023, 3:06 p.m.)
Indexed 4 weeks, 2 days ago (July 30, 2025, 10:27 a.m.)
Issued 28 years, 5 months ago (March 1, 1997)
Published 28 years, 5 months ago (March 1, 1997)
Published Print 28 years, 5 months ago (March 1, 1997)
Funders 0

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@article{Merry_1997, title={BCL-2 GENE FAMILY IN THE NERVOUS SYSTEM}, volume={20}, ISSN={1545-4126}, url={http://dx.doi.org/10.1146/annurev.neuro.20.1.245}, DOI={10.1146/annurev.neuro.20.1.245}, number={1}, journal={Annual Review of Neuroscience}, publisher={Annual Reviews}, author={Merry, D. E. and Korsmeyer, S. J.}, year={1997}, month=mar, pages={245–267} }