DOI: 10.1146/annurev.micro.61.080706.093409. Nitrogen Regulation in Bacteria and Archaea

Nitrogen Regulation in Bacteria and Archaea

10.1146/annurev.micro.61.080706.093409

Crossref journal-article

Annual Reviews

Annual Review of Microbiology (22)

Abstract

A wide range of Bacteria and Archaea sense cellular 2-oxoglutarate (2OG) as an indicator of nitrogen limitation. 2OG sensor proteins are varied, but most of those studied belong to the PII superfamily. Within the PII superfamily, GlnB and GlnK represent a widespread family of homotrimeric proteins (GlnB-K) that bind and respond to 2OG and ATP. In some bacterial phyla, GlnB-K proteins are covalently modified, depending on enzymes that sense cellular glutamine as an indicator of nitrogen sufficiency. GlnB-K proteins are central clearing houses of nitrogen information and bind and modulate a variety of nitrogen assimilation regulators and enzymes. NifI1 and NifI2 comprise a second widespread family of PII proteins (NifI) that are heteromultimeric, respond to 2OG and ATP, and bind and regulate dinitrogenase in Euryarchaeota and many Bacteria.

Bibliography

Leigh, J. A., & Dodsworth, J. A. (2007). Nitrogen Regulation in Bacteria and Archaea. Annual Review of Microbiology, 61(1), 349â377.

Authors 2

John A. Leigh (first)
Jeremy A. Dodsworth (additional)

References 111 Referenced 334

10.1016/S0021-9258(19)41060-0 / J. Biol. Chem. by Adler SP (1975)
10.1073/pnas.0506254102
10.1128/MMBR.65.1.80-105.2001
10.1074/jbc.M001935200
10.1128/JB.184.19.5364-5375.2002
10.1016/S0021-9258(18)46926-8 / J. Biol. Chem. by Atkinson MR (1994)
10.1111/j.1365-2958.2005.04855.x
10.1046/j.1365-2958.2003.03479.x
10.1046/j.1365-2958.2002.03153.x
10.1016/S0021-9258(18)34138-3 / J. Biol. Chem. by Bochner BR (1982)
10.1073/pnas.68.12.2949
10.1107/S0907444995007293
10.1128/jb.150.1.214-220.1982 / J. Bacteriol. by Chen YM (1982)
10.1074/jbc.M510945200
10.1073/pnas.94.4.1316
10.1128/JB.181.1.256-261.1999 / J. Bacteriol. by Cohen-Kupiec R (1999)
10.1073/pnas.0610348104
10.1093/emboj/21.4.536
10.1046/j.1365-2958.1998.00938.x
10.1099/mic.0.26512-0
10.1038/nrmicro954
10.1111/j.1365-2958.2005.04621.x
10.1073/pnas.0602278103
10.1074/jbc.M602477200
10.1128/jb.184.4.1028-1040.2002
10.1155/2002/362813
10.1111/j.1365-2958.2005.04511.x
10.1099/ijs.0.63815-0
10.1111/j.1365-2958.2006.05231.x
10.1046/j.1365-2958.2002.03150.x
10.1046/j.1365-2958.1999.01333.x
10.1016/j.femsre.2003.11.001
10.1111/j.1432-1033.1997.00869.x
10.1128/jb.177.20.5812-5817.1995
10.1073/pnas.74.4.1662
10.1073/pnas.0609796104
10.1099/00221287-144-6-1537
10.1128/JB.180.24.6661-6667.1998 / J. Bacteriol. by He L (1998)
10.1111/j.1365-2958.2004.04058.x
10.1074/jbc.M607582200
10.1128/JB.183.2.411-425.2001
10.1046/j.1365-2958.2002.03149.x
10.1073/pnas.82.22.7525
10.1016/S0014-5793(99)01624-5
10.1016/j.febslet.2006.08.054
10.1111/j.1365-2958.2005.04944.x
10.1006/jmbi.1996.0342
10.1128/JB.181.4.1156-1162.1999 / J. Bacteriol. by Jack R (1999)
10.1093/emboj/16.18.5562
10.1042/BST0330170
10.1074/jbc.M312399200
10.1128/JB.181.6.1906-1911.1999 / J. Bacteriol. by Jiang P (1999)
10.1021/bi980667m
10.1021/bi9802420
10.1021/bi980666u
10.1128/jb.179.13.4342-4353.1997
10.1074/jbc.270.30.17797
10.1073/pnas.85.14.4976
10.1128/JB.180.6.1504-1511.1998 / J. Bacteriol. by Kessler PS (1998)
10.1128/JB.183.3.882-889.2001
10.1093/genetics/152.4.1343 / Genetics by Kessler PS (1999)
10.1126/science.1101952
10.1007/978-94-011-5159-7_29
10.1046/j.1432-1327.2000.01043.x
10.1111/j.1574-6968.2007.00726.x
10.1046/j.1365-2958.2003.03293.x
10.1074/jbc.M411778200
10.1074/jbc.M112262200
10.1093/emboj/19.22.6041
10.1074/jbc.M410971200
10.1042/BST0330152
10.1128/JB.186.3.601-610.2004
10.1128/JB.187.3.972-979.2005
10.1074/jbc.M105297200 / J. Biol. Chem. by Muro-Pastor MI (2001)
10.1016/S0966-842X(00)01709-1
10.1016/j.mib.2005.02.011
10.1073/pnas.83.16.5909
10.1073/pnas.76.9.4544
10.1128/jb.133.1.139-148.1978 / J. Bacteriol. by Pahel G (1978)
10.1099/00221287-148-8-2405
10.1128/JB.185.17.5240-5247.2003
10.1021/bi000795m
10.1073/pnas.82.10.3173
10.1073/pnas.82.7.1979
10.1073/pnas.80.18.5554
10.1016/j.mib.2005.10.010
10.1128/JB.184.3.812-820.2002
10.1046/j.1365-2958.2002.02927.x
10.1128/jb.123.2.407-418.1975 / J. Bacteriol. by Senior PJ (1975)
10.1016/S1570-9639(04)00053-6
10.1074/jbc.R100055200
10.1146/annurev.biochem.69.1.183
10.1111/j.1365-2958.2004.04247.x
10.1016/S0168-9525(99)01887-9
10.1046/j.1365-2958.1996.6281349.x
10.1111/j.1574-6968.1995.tb07825.x
10.1073/pnas.97.8.3942
10.1007/s00438-006-0117-9
10.1016/j.femsle.2005.09.049
10.1016/S0092-8674(01)00572-4
10.1107/S0907444903019589
10.1046/j.1432-1327.2001.02074.x
10.1006/jmbi.1998.1979
10.1038/sj.emboj.7601492
10.1128/JB.183.5.1610-1620.2001
10.1128/JB.183.21.6159-6168.2001
10.1128/JB.182.4.983-992.2000
10.1128/JB.187.4.1254-1265.2005
10.1073/pnas.0306763101
10.1099/mic.0.28903-0
10.1128/JB.188.5.1866-1874.2006

Dates

Type	When
Created	18 years, 2 months ago (June 25, 2007, 1:20 p.m.)
Deposited	3 years, 10 months ago (Oct. 14, 2021, 11:28 a.m.)
Indexed	2 days, 1 hour ago (Sept. 4, 2025, 10:13 a.m.)
Issued	17 years, 11 months ago (Oct. 1, 2007)
Published	17 years, 11 months ago (Oct. 1, 2007)
Published Print	17 years, 11 months ago (Oct. 1, 2007)

Funders 0

None

BibTeX

@article{Leigh_2007, title={Nitrogen Regulation in Bacteria and Archaea}, volume={61}, ISSN={1545-3251}, url={http://dx.doi.org/10.1146/annurev.micro.61.080706.093409}, DOI={10.1146/annurev.micro.61.080706.093409}, number={1}, journal={Annual Review of Microbiology}, publisher={Annual Reviews}, author={Leigh, John A. and Dodsworth, Jeremy A.}, year={2007}, month=oct, pages={349–377} }

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