DOI: 10.1146/annurev.micro.58.030603.123818. Stationary-Phase Physiology

10.1146/annurev.micro.58.030603.123818

Crossref journal-article

Annual Reviews

Annual Review of Microbiology (22)

Abstract

▪ Abstract Bacteria enjoy an infinite capacity for reproduction as long as they reside in an environment supporting growth. However, their rapid growth and efficient metabolism ultimately results in depletion of growth-supporting substrates and the population of cells enters a phase defined as the stationary phase of growth. In this phase, their reproductive ability is gradually lost. The molecular mechanism underlying this cellular degeneration has not been fully deciphered. Still, recent analysis of the physiology and molecular biology of stationary-phase E. coli cells has revealed interesting similarities to the aging process of higher organisms. The similarities include increased oxidation of cellular constituents and its target specificity, the role of antioxidants and oxygen tension in determining life span, and an apparent trade-off between activities related to reproduction and survival.

Bibliography

NystrÃ¶m, T. (2004). Stationary-Phase Physiology. Annual Review of Microbiology, 58(1), 161â181.

Authors 1

Thomas Nyström (first)

References 84 Referenced 315

10.1074/jbc.M101796200
10.1073/pnas.93.12.6059
10.1128/jb.177.23.6791-6797.1995
10.1093/emboj/20.18.5280
10.1006/jmbi.1996.0565
10.1006/abbi.1995.1465
10.1038/ncb836
10.1016/S0021-9258(19)61523-1 / J. Biol. Chem. by Cabiscol E (2000)
10.1016/S0891-5849(02)00914-0
10.1046/j.1365-2958.2002.03001.x
10.1073/pnas.0334340100
10.1038/sj.embor.embor799
10.1046/j.1365-2958.1998.00645.x
10.1073/pnas.100422497
10.1101/gad.12.21.3431
10.1074/jbc.274.37.26027
10.1016/S0891-5849(96)00154-2
10.1073/pnas.95.26.15481
10.1128/JB.182.19.5551-5555.2000
10.1128/jb.178.22.6443-6450.1996
10.1046/j.1365-2958.1998.00990.x
10.1016/j.tim.2003.08.003
10.1016/S0531-5565(96)00030-7
10.1128/jb.175.24.7982-7989.1993
10.1126/science.1059361
10.1128/JB.182.3.561-572.2000
10.1007/978-1-4615-5925-2_3
10.1128/jb.168.2.486-493.1986
10.1104/pp.011024
10.1016/0092-8674(93)90655-A
10.1128/MMBR.66.3.373-395.2002
10.1128/jb.179.21.6688-6691.1997
10.1128/jb.170.9.3910-3914.1988
10.1101/gad.227902
10.1038/270301a0
10.1146/annurev.mi.41.100187.000325
10.1146/annurev.mi.47.100193.004231
10.1007/978-1-4899-2439-1_10
10.1074/jbc.C000128200
10.1046/j.1365-2958.2000.01714.x
10.1128/jb.177.16.4676-4680.1995
10.1111/j.1365-2958.1991.tb01825.x
10.1126/science.290.5499.2144
10.1074/jbc.M209268200
10.1126/science.1087911
10.1074/jbc.M209881200
10.1111/j.1365-2958.1991.tb01819.x
10.1126/science.1087782
10.1128/JB.184.3.806-811.2002
10.1007/BF00290116
10.1111/j.1365-2958.1994.tb01069.x
10.1016/S0966-842X(00)88901-5
10.1016/S1369-5274(99)80037-X
10.1016/S1369-5274(02)00367-3
10.1002/bies.10233
{'key': 'B56', 'first-page': '1599', 'volume': '135', 'author': 'Nyström T', 'year': '1989', 'journal-title': 'J. Gen. Microbiol.'} / J. Gen. Microbiol. by Nyström T (1989)
10.1002/j.1460-2075.1996.tb00686.x
10.1111/j.1365-2958.1994.tb00334.x
10.1016/0092-8674(78)90241-6
10.1073/pnas.49.4.517
10.1038/362305a0
10.1046/j.1365-2958.2002.03027.x
10.1016/S0092-8674(02)01248-5
10.1099/00221287-93-1-1
{'key': 'B65', 'volume-title': 'The Outer Reaches of Life', 'author': 'Postgate JR', 'year': '1994'} / The Outer Reaches of Life by Postgate JR (1994)
10.1074/jbc.M201225200
10.1074/jbc.M201306200
10.1128/jb.160.3.1041-1046.1984 / J. Bacteriol. by Reeve CA (1984)
10.1128/jb.157.3.758-763.1984 / J. Bacteriol. by Reeve CA (1984)
{'key': 'B70', 'volume-title': 'Evolutionary Biology of Aging', 'author': 'Rose MR', 'year': '1991'} / Evolutionary Biology of Aging by Rose MR (1991)
10.1046/j.1365-2958.2002.03131.x
10.1016/S0891-5849(02)00856-0
10.1073/pnas.90.15.7255
10.1128/IAI.70.11.6373-6382.2002
10.1099/13500872-145-1-15
10.1128/MCB.19.1.216
10.1074/jbc.273.5.3027
10.1046/j.1365-2958.2002.02787.x
10.1002/elps.1150111205
10.1128/JB.185.1.115-125.2003
10.1093/embo-reports/kvd106
10.1016/S0014-5793(97)01570-6
10.2307/2406060
10.1073/pnas.94.21.11168

Dates

Type	When
Created	20 years, 10 months ago (Oct. 15, 2004, 8:54 a.m.)
Deposited	3 years, 10 months ago (Oct. 14, 2021, 11:45 a.m.)
Indexed	3 days, 8 hours ago (Aug. 29, 2025, 5:45 a.m.)
Issued	20 years, 11 months ago (Oct. 1, 2004)
Published	20 years, 11 months ago (Oct. 1, 2004)
Published Print	20 years, 11 months ago (Oct. 1, 2004)

Funders 0

None

BibTeX

@article{Nystr_m_2004, title={Stationary-Phase Physiology}, volume={58}, ISSN={1545-3251}, url={http://dx.doi.org/10.1146/annurev.micro.58.030603.123818}, DOI={10.1146/annurev.micro.58.030603.123818}, number={1}, journal={Annual Review of Microbiology}, publisher={Annual Reviews}, author={Nyström, Thomas}, year={2004}, month=oct, pages={161–181} }

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    "issue": "1",
    "published-print": {
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        [
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          10,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1146/annurev.micro.58.030603.123818"
  ],
  "URL": "http://dx.doi.org/10.1146/annurev.micro.58.030603.123818",
  "relation": {},
  "ISSN": [
    "0066-4227",
    "1545-3251"
  ],
  "subject": [],
  "container-title-short": "Annu. Rev. Microbiol.",
  "published": {
    "date-parts": [
      [
        2004,
        10,
        1
      ]
    ]
  }
}