Abstract
▪ Abstract Microbes produce an extraordinary array of microbial defense systems. These include classical antibiotics, metabolic by-products, lytic agents, numerous types of protein exotoxins, and bacteriocins. The abundance and diversity of this potent arsenal of weapons are clear. Less clear are their evolutionary origins and the role they play in mediating microbial interactions. The goal of this review is to explore what we know about the evolution and ecology of the most abundant and diverse family of microbial defense systems: the bacteriocins. We summarize current knowledge of how such extraordinary protein diversity arose and is maintained in microbial populations and what role these toxins play in mediating microbial population-level and community-level dynamics. In the latter half of this review we focus on the potential role bacteriocins may play in addressing human health concerns and the current role they serve in food preservation.
References
102
Referenced
946
10.1128/AAC.26.3.328
10.1128/aem.55.5.1187-1191.1989
/ Appl. Environ. Microbiol. by Belkum MJ (1989)10.1016/S1383-8121(96)80070-4
10.1007/BF01569434
10.1016/S0168-1605(00)00372-X
10.1007/BF00248693
10.1128/AAC.39.3.714
10.1128/aem.59.9.3003-3010.1993
/ Appl. Environ. Microbiol. by Bruno MEC (1993)10.1016/S0021-9258(18)37587-2
/ J. Biol. Chem. by Buchman G (1988)10.1073/pnas.78.10.6324
10.1128/jb.179.2.548-551.1997
10.1128/aem.55.6.1329-1333.1989
/ Appl. Environ. Microbiol. by Chung K (1989)10.1146/annurev.bb.24.060195.003143
{'key': 'b14', 'first-page': '1775', 'volume': '32', 'author': 'Craven JA', 'year': '1971', 'journal-title': 'Am. J. Vet. Res.'}
/ Am. J. Vet. Res. by Craven JA (1971)10.1073/pnas.012399899
10.1128/aem.62.10.3662-3667.1996
/ Appl. Environ. Microbiol. by de Ruyter PGGA (1996)10.1006/plas.1997.1303
10.1099/00221287-136-3-555
10.1046/j.1472-765X.1998.00255.x
10.1139/m96-004
10.1128/aem.58.11.3730-3743.1992
/ Appl. Environ. Microbiol. by Engelke G (1992)10.1128/aem.60.3.814-825.1994
/ Appl. Environ. Microbiol. by Engelke G (1994)10.1016/S0168-6445(99)00031-5
10.1099/13500872-141-11-2977
10.2307/2640807
{'key': 'b26', 'first-page': '951', 'volume': '178', 'author': 'Ferrer S', 'year': '1996', 'journal-title': 'Am. Soc. Microbiol.'}
/ Am. Soc. Microbiol. by Ferrer S (1996)-
Freter R. 1983. Mechanisms that control the microflora in the large intestine. InHuman Intestinal Microflora in Health and Disease. New York: Academic
(
10.1016/B978-0-12-341280-5.50008-2
) 10.1099/13500872-145-3-655
10.1099/00221287-144-8-2233
10.1016/S0969-2126(97)00188-3
10.1021/ja00747a073
10.1016/0923-2508(96)80293-2
10.1002/1097-0282(2000)55:1<62::AID-BIP60>3.0.CO;2-Y
10.1128/br.39.4.464-515.1975
/ Bacteriol. Rev. by Hardy KG (1975)10.1128/jb.173.23.7491-7500.1991
{'key': 'b36', 'volume-title': "Bergey's Manual of Determinative Bacteriology.", 'author': 'Holt JG', 'year': '1994'}
/ Bergey's Manual of Determinative Bacteriology. by Holt JG (1994)10.1128/JB.180.19.5192-5202.1998
/ J. Bacteriol. by Hu P (1998)10.3181/00379727-130-33773
10.1128/mr.59.2.171-200.1995
/ Microbiol. Rev. by Jack RW (1995)10.1099/13500872-142-7-1569
{'key': 'b41', 'volume-title': 'Bacteriocins, Microcins and Lantibiotics, Vol. 65.', 'author': 'James R', 'year': '1991'}
/ Bacteriocins, Microcins and Lantibiotics, Vol. 65. by James R (1991)10.1128/jb.167.2.439-446.1986
- Jung G, Sahl HG. 1991. Lantibiotics: a survey. InNisin and Novel Lantibiotics, pp. 1–34. Leiden, The Netherlands: ESCOM
10.1128/jb.171.3.1597-1601.1989
10.1128/jb.99.3.888-890.1969
/ J. Bacteriol. by Kelstrup J (1969)10.1038/nature00823
10.1016/0300-9084(88)90206-4
10.1146/annurev.mi.36.100182.001013
10.1074/jbc.270.45.27299
10.1111/j.1432-1033.1993.tb18143.x
-
Lau PCK, Parsons M, Uchimura T. 1992. Molecular evolution of E colicin plasmids with emphasis on the endonuclease types. See Ref.41, 65:353–78
(
10.1007/978-3-642-76974-0_31
) 10.1099/13500872-141-7-1629
10.1073/pnas.022641999
10.1073/pnas.97.4.1938
10.1146/annurev.micro.55.1.165
- Montville TJ, Winkowski K. 1997. Biologically based preservation systems and probiotic bacteria. InFood Microbiology: Fundamentals and Frontiers. Washington, DC: ASM
10.1128/AAC.44.1.24-29.2000
10.1128/jb.173.5.1779-1788.1991
10.1126/science.257.5073.1064
10.1128/jb.174.17.5686-5692.1992
10.4315/0362-028X-49.12.1003
10.1006/plas.2001.1525
10.1128/JB.182.17.4951-4958.2000
{'key': 'b64', 'first-page': '168', 'volume': '1', 'author': 'Pugsley A', 'year': '1984', 'journal-title': 'Microbiol. Sci.'}
/ Microbiol. Sci. by Pugsley A (1984)- Pugsley AP, Oudega B. 1987. Methods for studying colicins and their plasmids. InPlasmids, a Practical Approach, ed. KG Hardy, pp. 105–61. Oxford: IRL
10.1099/13500872-145-5-1227
10.2307/4010251
{'key': 'b68', 'first-page': '1380', 'volume': '10', 'author': 'Riley M', 'year': '1993', 'journal-title': 'Mol. Biol. Evol.'}
/ Mol. Biol. Evol. by Riley M (1993){'key': 'b69', 'first-page': '1048', 'volume': '10', 'author': 'Riley MA', 'year': '1993', 'journal-title': 'Mol. Biol. Evol.'}
/ Mol. Biol. Evol. by Riley MA (1993)10.1146/annurev.genet.32.1.255
10.1099/00221287-146-7-1671
10.1099/00221287-138-7-1345
10.1006/plas.2001.1519
10.1073/pnas.91.23.11276
10.1139/m82-019
10.1111/j.1365-2958.1989.tb00238.x
10.1023/A:1002069416067
{'key': 'b78', 'first-page': '927', 'volume': '13', 'author': 'Roy PH', 'year': '1997', 'journal-title': 'Med. Sci.'}
/ Med. Sci. by Roy PH (1997){'key': 'b79', 'first-page': '41', 'volume': '100', 'author': 'Saadoun I', 'year': '1999', 'journal-title': 'Microbios'}
/ Microbios by Saadoun I (1999)10.1128/jb.175.19.6179-6185.1993
- Sano Y, Matsui H, Kobayashi M, Kageyama M. 1990. Pyocins S1 and S2, bacteriocins ofPseudomonas aeruginosa. InPseudomonas: Biotransformations, Pathogenesis, and Evolving Biotechnology, ed. S Silver, pp. 352–58. Washington, DC: ASM
10.1128/jb.175.10.2907-2916.1993
10.1128/aem.55.8.1901-1906.1989
/ Appl. Environ. Microbiol. by Schillinger U (1989)10.1111/j.1432-1033.1989.tb14815.x
- Shand R, Price L, O'Connor EM. 1998. Halocins: protein antibiotics from hypersaline environments. InMicrobiology and Biogeochemistry of Hypersaline Environments, ed. A Oren, Chapter 24, pp. 295–306. Boca Raton, FL: CRC
10.1128/jb.179.15.4919-4928.1997
10.1128/JB.183.13.3949-3957.2001
10.1016/S0168-1605(97)01254-3
{'key': 'b89', 'first-page': '152', 'volume-title': 'Theoret. Popul. Biol.', 'volume': '53', 'author': 'Stewart FM', 'year': '1998'}
/ Theoret. Popul. Biol. by Stewart FM (1998)10.1128/br.40.3.722-756.1976
/ Bact. Rev. by Tagg JR (1976)10.1099/13500872-142-8-2175
10.1093/oxfordjournals.molbev.a025806
10.1016/S0169-5347(97)01127-0
{'key': 'b94', 'first-page': '2655', 'volume': '135', 'author': 'Torreblanca M', 'year': '1989', 'journal-title': 'J. Gen. Microbiol.'}
/ J. Gen. Microbiol. by Torreblanca M (1989)10.1111/j.1472-765X.1994.tb00943.x
10.1128/AAC.7.2.139
10.1128/jb.175.9.2578-2588.1993
10.1111/j.1365-2672.1992.tb04981.x
10.1007/s002840010159
10.1554/0014-3820(2001)055[1110:GTIAPE]2.0.CO;2
10.1007/978-1-4757-0322-1_2
10.1128/AAC.43.6.1350
Dates
Type | When |
---|---|
Created | 22 years, 11 months ago (Sept. 4, 2002, 4:35 p.m.) |
Deposited | 3 years, 10 months ago (Oct. 14, 2021, 12:19 p.m.) |
Indexed | 21 hours, 58 minutes ago (Aug. 30, 2025, 12:48 p.m.) |
Issued | 22 years, 10 months ago (Oct. 1, 2002) |
Published | 22 years, 10 months ago (Oct. 1, 2002) |
Published Print | 22 years, 10 months ago (Oct. 1, 2002) |
@article{Riley_2002, title={Bacteriocins: Evolution, Ecology, and Application}, volume={56}, ISSN={1545-3251}, url={http://dx.doi.org/10.1146/annurev.micro.56.012302.161024}, DOI={10.1146/annurev.micro.56.012302.161024}, number={1}, journal={Annual Review of Microbiology}, publisher={Annual Reviews}, author={Riley, Margaret A. and Wertz, John E.}, year={2002}, month=oct, pages={117–137} }