DOI: 10.1146/annurev.micro.56.012302.160830. Growing Old: Metabolic Control and Yeast Aging

Growing Old: Metabolic Control and Yeast Aging

10.1146/annurev.micro.56.012302.160830

Crossref journal-article

Annual Reviews

Annual Review of Microbiology (22)

Abstract

▪ Abstract The metabolic characteristics of a yeast cell determine its life span. Depending on conditions, stress resistance can have either a salutary or a deleterious effect on longevity. Gene dysregulation increases with age, and countering it increases life span. These three determinants of yeast longevity may be interrelated, and they are joined by a potential fourth, genetic stability. These factors can also operate in phylogenetically diverse species. Adult longevity seems to borrow features from the genetic programs of dormancy to provide the metabolic and stress resistance resources necessary for extended survival. Both compensatory and preventive mechanisms determine life span, while epigenetic factors and the element of chance contribute to the role that genes and environment play in aging.

Bibliography

Jazwinski, S. M. (2002). Growing Old: Metabolic Control and Yeast Aging. Annual Review of Microbiology, 56(1), 769â792.

Authors 1

S. Michal Jazwinski (first)

References 122 Referenced 69

10.1101/gad.14.15.1872 / Genes Dev. by Ashrafi K (2000)
10.1073/pnas.96.16.9100
10.1016/S0378-1097(99)00308-0
10.1002/(SICI)1097-0061(199910)15:14<1511::AID-YEA482>3.3.CO;2-P
10.1091/mbc.10.4.1043
10.1126/science.1062329
10.1038/45287
10.1073/pnas.250477697
10.1016/S0378-1119(01)00812-5
10.1146/annurev.biochem.66.1.717
10.1073/pnas.97.9.4961
10.1152/ajpcell.1994.266.4.C946 / Am. J. Physiol. by Cartee GD (1994)
10.1111/j.1365-2958.1990.tb00568.x
10.1074/jbc.C000229200
10.1128/MCB.15.5.2420
10.1073/pnas.240345197
10.1016/S0531-5565(00)00169-8
10.1016/S1097-2765(00)80472-4
10.1146/annurev.biochem.67.1.27
10.1074/jbc.272.48.30196
10.1016/S0021-9258(17)40700-9 / J. Biol. Chem. by D'mello NP (1994)
10.1128/jb.173.21.6709-6713.1991
10.1128/jb.171.1.37-42.1989
10.1016/0092-8674(94)90153-8
10.1091/mbc.12.2.297
10.1126/science.1059497
{'key': 'b27', 'volume-title': 'Longevity, Senescence, and the Genome.', 'author': 'Finch CE', 'year': '1990'} / Longevity, Senescence, and the Genome. by Finch CE (1990)
10.1093/emboj/20.23.6783
Gancedo C, Serrano R. 1989.Energy-yielding metabolism.InThe Yeasts, ed. AH Rose, JS Harrison, pp. 205–59. San Diego: Academic
10.1016/0092-8674(92)90079-R
10.1093/emboj/20.11.2655
10.1016/S0047-6374(00)00119-6
10.1016/S0962-8924(99)01694-3
10.1046/j.1365-2443.1999.00288.x
10.1016/S0092-8674(00)00015-5
10.1038/35001622
10.1111/j.1365-2958.1990.tb00601.x
10.1007/BF01435986
10.1126/science.273.5271.54
10.1016/S0966-842X(99)01509-7
Jazwinski SM. 1999.Nonlinearity of the aging process revealed in studies with yeast.InMolecular Biology of Aging, ed. VA Bohr, BFC Clark, T Stevnsner, pp. 35–44. Copenhagen: Munksgaard
10.1016/S0197-4580(99)00095-0
10.1016/S0168-9525(00)02119-3
10.1111/j.1749-6632.2000.tb06632.x
10.1016/S0047-6374(01)00244-5
10.1016/S0531-5565(98)00029-1
10.1006/jtbi.2001.2434
10.1128/MCB.17.3.1110
10.1096/fj.00-0242fje
10.1101/gr.8.3.268
10.1016/S0531-5565(02)00064-5
10.1016/S0168-9525(98)01637-0
10.1073/pnas.83.21.8172
10.1002/(SICI)1520-6408(1996)18:2<154::AID-DVG8>3.0.CO;2-8
10.1073/pnas.081061898
10.1083/jcb.127.6.1985
10.1016/S0092-8674(01)00306-3
10.1091/mbc.10.10.3125
10.1006/bbrc.1996.0240
10.1093/genetics/152.1.179 / Genetics by Kirchman PA (1999)
10.1083/jcb.151.4.863
{'key': 'b62', 'first-page': '2507', 'volume': '134', 'author': 'Lagunas R', 'year': '1988', 'journal-title': 'J. Gen. Microbiol.'} / J. Gen. Microbiol. by Lagunas R (1988)
{'key': 'b63', 'author': 'Lai C-Y', 'year': '2002', 'journal-title': 'Genetics.'} / Genetics. by Lai C-Y (2002)
10.1073/pnas.110148297
10.1046/j.1365-2958.2001.02317.x
10.1126/science.285.5432.1390
10.1038/77046
10.1073/pnas.88.10.4250
10.1073/pnas.97.7.3467
10.1016/0092-8674(93)90050-Z
10.1126/science.289.5487.2126
10.1128/MCB.19.10.6720
10.1093/emboj/20.24.7209
10.1016/S0197-4580(99)00089-5
10.1093/genetics/154.2.609 / Genetics by Lorenz MC (2000)
10.1016/0092-8674(89)90132-3
10.1016/S0962-8924(98)01298-7
10.1093/emboj/20.3.411
10.1002/j.1460-2075.1993.tb05849.x
10.1016/0531-5565(94)00028-2
10.1042/bj3350465
Miller JJ. 1989. Sporulation inSaccharomyces cerevisiae. InThe Yeasts, ed. AH Rose, JS Harrison, pp. 489–550. San Diego: Academic
10.1038/1831751a0
10.1016/0047-6374(92)90081-N
10.1016/0047-6374(80)90028-7
10.1101/gad.10.4.382
10.1083/jcb.142.3.613
10.1006/geno.2001.6614
10.1126/science.3027892
10.1007/BF00267979
10.1073/pnas.181486098
10.1016/S0960-9822(00)00298-0
10.1073/pnas.93.25.14503
10.1091/mbc.12.11.3417
10.1074/jbc.275.18.13330
10.1091/mbc.11.6.2103
10.1006/excr.1998.4276
10.1006/excr.1998.4279
10.1073/pnas.91.23.10771
10.1126/science.277.5330.1313
10.1016/S0968-0004(98)01188-8
10.1128/jb.179.5.1513-1520.1997
10.1021/bi00016a031
10.1016/S0092-8674(00)81038-7
10.1073/pnas.97.12.6658
10.1128/MCB.19.4.3184
10.1016/S0021-9258(17)32357-8 / J. Biol. Chem. by Sun J (1994)
10.1126/science.290.5490.341
10.1016/B978-0-12-429350-2.50011-5
10.1046/j.1365-2958.1999.01538.x
10.1038/35065638
10.1101/gad.2.5.517
10.1074/jbc.M006807200
10.1126/science.280.5365.855
10.18388/abp.1999_4158 / Acta Biochim. Pol. by Wawryn J (1999)
10.1152/physiolgenomics.2001.5.2.67
10.1128/mr.57.2.383-401.1993 / Microbiol. Rev. by Werner-Washburne M (1993)
10.1038/46567
10.1016/S0531-5565(01)00154-1
10.1126/science.272.5259.258
10.1093/emboj/19.12.2824
10.1101/gad.12.13.1941

Dates

Type	When
Created	22 years, 11 months ago (Sept. 4, 2002, 4:35 p.m.)
Deposited	2 years, 4 months ago (April 24, 2023, 6:10 a.m.)
Indexed	11 months, 3 weeks ago (Sept. 9, 2024, 5:08 p.m.)
Issued	22 years, 11 months ago (Oct. 1, 2002)
Published	22 years, 11 months ago (Oct. 1, 2002)
Published Print	22 years, 11 months ago (Oct. 1, 2002)

Funders 0

None

BibTeX

@article{Jazwinski_2002, title={Growing Old: Metabolic Control and Yeast Aging}, volume={56}, ISSN={1545-3251}, url={http://dx.doi.org/10.1146/annurev.micro.56.012302.160830}, DOI={10.1146/annurev.micro.56.012302.160830}, number={1}, journal={Annual Review of Microbiology}, publisher={Annual Reviews}, author={Jazwinski, S. Michal}, year={2002}, month=oct, pages={769–792} }

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